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Journal of fungi (Basel, Switzerland)
Aug 26, 2017;3 (3):

Natural Antimicrobial Peptides as Inspiration for Design of a New Generation Antifungal Compounds.

Ma��gorzata Bondaryk, Monika Staniszewska, Paulina Zieli��ska, Zofia Urba��czyk-Lipkowska
Author Information
  1. Ma��gorzata Bondaryk: National Institute of Public Health-National Institute of Hygiene, Chocimska 24, 00-791 Warsaw, Poland. mbondaryk@pzh.gov.pl.
  2. Monika Staniszewska: National Institute of Public Health-National Institute of Hygiene, Chocimska 24, 00-791 Warsaw, Poland. mstaniszewska@pzh.gov.pl. ORCID
  3. Paulina Zieli��ska: Institute of Organic Chemistry, Polish Academy of Sciences, 01-224 Warsaw, Poland. paulina.zielinska@gmail.com.
  4. Zofia Urba��czyk-Lipkowska: Institute of Organic Chemistry, Polish Academy of Sciences, 01-224 Warsaw, Poland. zofia.lipkowska@icho.edu.pl.
PMID: 29371563 DOI: 10.3390/jof3030046

Abstract

Invasive fungal infections are associated with high mortality rates, despite appropriate antifungal therapy. Limited therapeutic options, resistance development and the high mortality of invasive fungal infections brought about more concern triggering the search for new compounds capable of interfering with fungal viability and virulence. In this context, Peptides gained attention as promising candidates for the antimycotics development. Variety of structural and functional characteristics identified for various natural antifungal Peptides makes them excellent starting points for design novel drug candidates. Current review provides a brief overview of natural and synthetic antifungal Peptides.

Keywords

Candida species antifungal peptides fungal pathogens

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