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Nature reviews. Drug discovery
06, 2018;17 (6): 413-434.

Post-exposure treatments for Ebola and Marburg virus infections.

Robert W Cross, Chad E Mire, Heinz Feldmann, Thomas W Geisbert
Author Information
  1. Robert W Cross: Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas 77555, USA.
  2. Chad E Mire: Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas 77555, USA.
  3. Heinz Feldmann: Laboratory of Virology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA.
  4. Thomas W Geisbert: Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas 77555, USA.
PMID: 29375139 DOI: 10.1038/nrd.2017.251

Abstract

The filoviruses - Ebola virus and Marburg virus - cause lethal haemorrhagic fever in humans and non-human primates (NHPs). Filoviruses present a global health threat both as naturally acquired diseases and as potential agents of bioterrorism. In the recent 2013-2016 outbreak of Ebola virus, the most promising therapies for post-exposure use with demonstrated efficacy in the gold-standard NHP models of filovirus disease were unable to show statistically significant protection in patients infected with Ebola virus. This Review briefly discusses these failures and what has been learned from these experiences, and summarizes the current status of post-exposure medical countermeasures in development, including antibodies, small interfering RNA and small molecules. We outline how our current knowledge could be applied to the identification of novel interventions and ways to use interventions more effectively.

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Grants

  1. U19 AI109711/NIAID NIH HHS
Journal Article Review Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural
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