Susceptibility of Clinical Staphylococcus aureus Small-Colony Variants to β-Lactam and Non-β-Lactam Antibiotics.

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Evgeny A Idelevich, André Kriegeskorte, Nina Schleimer, Georg Peters, Christof von Eiff, Karsten Becker

Author Information

Evgeny A Idelevich: Institute of Medical Microbiology, University Hospital Münster, Münster, Germany.
André Kriegeskorte: Institute of Medical Microbiology, University Hospital Münster, Münster, Germany.
Nina Schleimer: Institute of Medical Microbiology, University Hospital Münster, Münster, Germany.
Georg Peters: Institute of Medical Microbiology, University Hospital Münster, Münster, Germany.
Christof von Eiff: Institute of Medical Microbiology, University Hospital Münster, Münster, Germany.
Karsten Becker: Institute of Medical Microbiology, University Hospital Münster, Münster, Germany kbecker@uni-muenster.de. ORCID

PMID: 29378720 DOI: 10.1128/AAC.02532-17

The small-colony variant (SCV) phenotype has been associated with relapsing and antibiotic-refractory infections. However, little is known about the activities of antibiotics on clinical SCVs. Here, we demonstrated that SCVs without detectable auxotrophies were at least as susceptible to most β-lactam and non-β-lactam antibiotics as their corresponding clonally identical strains with a normal phenotype. After prolonged incubation, a regrowth phenomenon has been observed in gradient diffusion inhibition zones irrespective of the strains' phenotype.

Staphylococcus aureus aminoglycosides antibiotic resistance daptomycin lincosamides linezolid resistance small-colony variants susceptibility trimethoprim β-lactam antibiotics

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Anti-Bacterial Agents

Daptomycin

Lincosamides

Linezolid

Microbial Sensitivity Tests

Staphylococcus aureus

Trimethoprim

beta-Lactams