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02, 2018;7 (1): 95-122.

Stimulus-responsive liposomes as smart nanoplatforms for drug delivery applications.

Parham Sahandi Zangabad, Soroush Mirkiani, Shayan Shahsavari, Behrad Masoudi, Maryam Masroor, Hamid Hamed, Zahra Jafari, Yasamin Davatgaran Taghipour, Hura Hashemi, Mahdi Karimi, Michael R Hamblin
Author Information
  1. Parham Sahandi Zangabad: Research Center for Pharmaceutical Nanotechnology (RCPN), Tabriz University of Medical Science (TUOMS), Tabriz, Iran.
  2. Soroush Mirkiani: Advanced Nanobiotechnology and Nanomedicine Research Group (ANNRG), Iran University of Medical Sciences, Tehran, Iran.
  3. Shayan Shahsavari: Advanced Nanobiotechnology and Nanomedicine Research Group (ANNRG), Iran University of Medical Sciences, Tehran, Iran.
  4. Behrad Masoudi: Advanced Nanobiotechnology and Nanomedicine Research Group (ANNRG), Iran University of Medical Sciences, Tehran, Iran.
  5. Maryam Masroor: Advanced Nanobiotechnology and Nanomedicine Research Group (ANNRG), Iran University of Medical Sciences, Tehran, Iran.
  6. Hamid Hamed: Advanced Nanobiotechnology and Nanomedicine Research Group (ANNRG), Iran University of Medical Sciences, Tehran, Iran.
  7. Zahra Jafari: Advanced Nanobiotechnology and Nanomedicine Research Group (ANNRG), Iran University of Medical Sciences, Tehran, Iran.
  8. Yasamin Davatgaran Taghipour: Advanced Nanobiotechnology and Nanomedicine Research Group (ANNRG), Iran University of Medical Sciences, Tehran, Iran.
  9. Hura Hashemi: Advanced Nanobiotechnology and Nanomedicine Research Group (ANNRG), Iran University of Medical Sciences, Tehran, Iran.
  10. Mahdi Karimi: Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.
  11. Michael R Hamblin: Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
PMID: 29404233 DOI: 10.1515/ntrev-2017-0154

Abstract

Liposomes are known to be promising nanoparticles (NPs) for drug delivery applications. Among different types of self-assembled NPs, liposomes stand out for their non-toxic nature, and their possession of dual hydrophilic-hydrophobic domains. Advantages of liposomes include the ability to solubilize hydrophobic drugs, the ability to incorporate different hydrophilic and lipophilic drugs at the same time, lessening the exposure of host organs to potentially toxic drugs and allowing modification of the surface by a variety of different chemical groups. This modification of the surface, or of the individual constituents, may be used to achieve two important goals. Firstly, ligands for active targeting can be attached that are recognized by cognate receptors over-expressed on the target cells of tissues. Secondly, modification can be used to impart a stimulus-responsive or "smart" character to the liposomes, whereby the cargo is released on demand only when certain internal stimuli (pH, reducing agents, specific enzymes) or external stimuli (light, magnetic field or ultrasound) are present. Here, we review the field of smart liposomes for drug delivery applications.

Keywords

Liposomes drug delivery external/internal stimuli nanocarriers smart stimulus-responsive

References

  1. ACS Nano. 2012 Apr 24;6(4):3491-8 [PMID: 22409425]
  2. Cancer. 2009 Aug 1;115(15):3475-82 [PMID: 19536896]
  3. Leuk Lymphoma. 2005 Jun;46(6):795-802 [PMID: 16019523]
  4. Lancet Oncol. 2002 Aug;3(8):487-97 [PMID: 12147435]
  5. Adv Drug Deliv Rev. 2008 Jun 30;60(10):1137-52 [PMID: 18486269]
  6. ACS Appl Mater Interfaces. 2010 Mar;2(3):768-73 [PMID: 20356279]
  7. Proc Natl Acad Sci U S A. 1997 Aug 5;94(16):8795-800 [PMID: 9238057]
  8. ACS Nano. 2015 Mar 24;9(3):2904-16 [PMID: 25695371]
  9. Adv Mater. 2016 Nov;28(42):9341-9348 [PMID: 27578301]
  10. J Control Release. 2000 Oct 3;69(1):43-52 [PMID: 11018545]
  11. Curr Drug Deliv. 2016;13(6):909-22 [PMID: 26718489]
  12. Biomacromolecules. 2016 Apr 11;17(4):1303-11 [PMID: 26956911]
  13. J Mol Biol. 1965 Aug;13(1):238-52 [PMID: 5859039]
  14. Eur J Pharm Sci. 2011 Mar 18;42(4):380-6 [PMID: 21238586]
  15. ACS Nano. 2016 Aug 23;10(8):7749-60 [PMID: 27504891]
  16. ACS Appl Mater Interfaces. 2016 Aug 24;8(33):21107-33 [PMID: 27349465]
  17. J Liposome Res. 2016;26(2):87-95 [PMID: 25826202]
  18. Bioconjug Chem. 2011 Apr 20;22(4):523-8 [PMID: 21405113]
  19. Biochim Biophys Acta. 2001 Dec 1;1515(2):144-58 [PMID: 11718670]
  20. Adv Drug Deliv Rev. 2014 Jun;72:3-14 [PMID: 24389162]
  21. J Control Release. 2016 Sep 28;238:31-42 [PMID: 27444816]
  22. J Control Release. 2013 Jul 10;169(1-2):112-25 [PMID: 23583706]
  23. Photochem Photobiol. 2009 Jul-Aug;85(4):848-60 [PMID: 19222790]
  24. Nano Today. 2015 Aug 1;10(4):451-467 [PMID: 26644797]
  25. Biochemistry. 1996 Feb 27;35(8):2618-24 [PMID: 8611565]
  26. Expert Opin Drug Deliv. 2014 Jan;11(1):83-100 [PMID: 24320104]
  27. Science. 1979 Apr 13;204(4389):188-91 [PMID: 432641]
  28. Int J Nanomedicine. 2016 May 09;11:1973-83 [PMID: 27274229]
  29. J Control Release. 2015 Dec 10;219:43-60 [PMID: 26407671]
  30. Angew Chem Int Ed Engl. 2014 Nov 10;53(46):12320-64 [PMID: 25294565]
  31. Biomacromolecules. 2015 Sep 14;16(9):2618-23 [PMID: 26212580]
  32. J Zhejiang Univ Sci B. 2012 Dec;13(12):981-9 [PMID: 23225853]
  33. ACS Appl Mater Interfaces. 2013 Nov 13;5(21):10895-903 [PMID: 24127854]
  34. Biochemistry. 1985 Oct 8;24(21):5967-71 [PMID: 4084501]
  35. Langmuir. 2016 May 3;32(17):4169-78 [PMID: 26987014]
  36. Macromolecules. 2013 Dec 10;46(23):9169-9180 [PMID: 28804160]
  37. Chem Rev. 2015 Oct 14;115(19):10938-66 [PMID: 26010257]
  38. Macromol Biosci. 2014 Apr;14(4):458-77 [PMID: 24616298]
  39. ACS Appl Mater Interfaces. 2014 Jul 9;6(13):10706-13 [PMID: 24941446]
  40. Int J Hyperthermia. 1999 Sep-Oct;15(5):345-70 [PMID: 10519688]
  41. J Biomed Nanotechnol. 2015 Feb;11(2):342-50 [PMID: 26349310]
  42. J Nanosci Nanotechnol. 2014 Jan;14(1):755-65 [PMID: 24730295]
  43. Eur J Pharm Biopharm. 2010 Aug;75(3):327-33 [PMID: 20434558]
  44. Acta Paediatr. 2004 Mar;93(3):412-4 [PMID: 15124849]
  45. J Control Release. 2015 Oct 28;216:69-77 [PMID: 26264832]
  46. Biomaterials. 2013 Apr;34(11):2773-86 [PMID: 23352118]
  47. Biol Pharm Bull. 2013;36(6):892-9 [PMID: 23727912]
  48. Orthop Nurs. 2007 Mar-Apr;26(2):86-93; quiz 94-5 [PMID: 17414375]
  49. Prog Biophys Mol Biol. 2007 Jan-Apr;93(1-3):3-83 [PMID: 17045633]
  50. Int J Nanomedicine. 2012;7:2621-30 [PMID: 22679372]
  51. Chem Commun (Camb). 2013 Apr 28;49(33):3431-3 [PMID: 23505630]
  52. Clin Infect Dis. 2002 Aug 15;35(4):359-66 [PMID: 12145716]
  53. Surv Ophthalmol. 2005 Mar-Apr;50(2):167-82 [PMID: 15749307]
  54. J Control Release. 2001 Sep 11;76(1-2):27-37 [PMID: 11532310]
  55. Nanoscale. 2014 Jul 7;6(13):7635-42 [PMID: 24898341]
  56. Int J Hyperthermia. 2016 May;32(3):254-64 [PMID: 26892114]
  57. J Microencapsul. 2016 May;33(3):257-62 [PMID: 27174396]
  58. Gynecol Oncol. 2006 Jun;101(3):423-8 [PMID: 16325239]
  59. Adv Drug Deliv Rev. 2001 Dec 31;53(3):307-19 [PMID: 11744174]
  60. Cancer Chemother Pharmacol. 2013 Mar;71(3):555-64 [PMID: 23212117]
  61. Expert Rev Vaccines. 2008 Oct;7(8):1141-50 [PMID: 18844588]
  62. Proc Natl Acad Sci U S A. 1978 Jul;75(7):3327-31 [PMID: 28524]
  63. Expert Opin Drug Deliv. 2016 Nov;13(11):1609-1623 [PMID: 27216915]
  64. Eur J Pharm Biopharm. 2011 Apr;77(3):458-64 [PMID: 21195760]
  65. Int J Pharm. 2006 Feb 17;309(1-2):94-100 [PMID: 16364578]
  66. Chem Commun (Camb). 2012 May 18;48(40):4869-71 [PMID: 22498879]
  67. J Nanosci Nanotechnol. 2015 Jun;15(6):4149-58 [PMID: 26369024]
  68. Nat Biotechnol. 2001 Apr;19(4):316-7 [PMID: 11283581]
  69. Bioconjug Chem. 2009 May 20;20(5):1054-7 [PMID: 19391618]
  70. Gynecol Oncol. 2016 May;141(2):357-363 [PMID: 26946092]
  71. Science. 1978 Dec 22;202(4374):1290-3 [PMID: 364652]
  72. Chem Commun (Camb). 2012 Jun 7;48(45):5647-9 [PMID: 22543447]
  73. Int J Nanomedicine. 2007;2(3):277-88 [PMID: 18019828]
  74. Carbohydr Polym. 2013 Apr 15;94(1):17-23 [PMID: 23544504]
  75. J Control Release. 2012 Jun 10;160(2):264-73 [PMID: 22182771]
  76. Curr Med Chem. 2012;19(15):2388-98 [PMID: 22455591]
  77. Nanoscale. 2015 Mar 12;7(12):5411-26 [PMID: 25731982]
  78. Int J Nanomedicine. 2012;7:5259-69 [PMID: 23091378]
  79. Bioimpacts. 2016;6(1):49-67 [PMID: 27340624]
  80. J Control Release. 2015 Dec 10;219:31-42 [PMID: 26208426]
  81. Nat Rev Cancer. 2005 Apr;5(4):321-7 [PMID: 15776004]
  82. J Pharm Pharmacol. 2002 Jan;54(1):51-8 [PMID: 11829129]
  83. Molecules. 2016 Sep 26;21(10): [PMID: 27681717]
  84. J Liposome Res. 2007;17(3-4):197-203 [PMID: 18027240]
  85. ACS Nano. 2015 Feb 24;9(2):1280-93 [PMID: 25599568]
  86. Curr Opin Colloid Interface Sci. 2011 Jun 1;16(3):203-214 [PMID: 21603081]
  87. Biochim Biophys Acta. 2002 Aug 19;1564(1):31-7 [PMID: 12100993]
  88. Chembiochem. 2009 Jan 26;10(2):251-6 [PMID: 19132694]
  89. Adv Colloid Interface Sci. 2014 May;207:32-42 [PMID: 24368133]
  90. Ultrason Sonochem. 2016 Jan;28:31-38 [PMID: 26384880]
  91. Anesth Analg. 2007 Jul;105(1):176-83 [PMID: 17578973]
  92. Chemistry. 2013 Nov 18;19(47):16113-21 [PMID: 24123292]
  93. Cancer Chemother Pharmacol. 2016 Feb;77(2):269-80 [PMID: 26666650]
  94. Menopause. 2006 Mar-Apr;13(2):222-31 [PMID: 16645536]
  95. Chem Pharm Bull (Tokyo). 2013;61(4):390-8 [PMID: 23385961]
  96. Adv Drug Deliv Rev. 2014 Jun;72:94-109 [PMID: 24462453]
  97. J Control Release. 1999 Aug 27;61(1-2):137-43 [PMID: 10469910]
  98. Nano Lett. 2011 Apr 13;11(4):1664-70 [PMID: 21351741]
  99. Pharm Res. 2012 Aug;29(8):2092-103 [PMID: 22451250]
  100. ACS Appl Mater Interfaces. 2016 Oct 26;8(42):28480-28494 [PMID: 27689441]
  101. Proc Natl Acad Sci U S A. 1987 Nov;84(22):7851-5 [PMID: 2446313]
  102. Cell. 1983 Apr;32(4):1069-79 [PMID: 6404557]
  103. Anesth Analg. 2005 Apr;100(4):1065-1074 [PMID: 15781524]
  104. RSC Adv. 2018 Dec 3;8(69):39786 [PMID: 35560733]
  105. J Pharm Pharmacol. 2007 Apr;59(4):469-83 [PMID: 17430630]
  106. Adv Mater. 2015 Mar 11;27(10):1647-62 [PMID: 25655424]
  107. Anal Chim Acta. 2015 Nov 5;900:10-20 [PMID: 26572835]
  108. Eur J Pharm Biopharm. 2015 Apr;91:66-74 [PMID: 25660909]
  109. Int J Hyperthermia. 2011;27(8):751-61 [PMID: 22098360]
  110. N Engl J Med. 1993 Mar 11;328(10):708-16 [PMID: 8433731]
  111. Biomaterials. 2014 Mar;35(9):3091-101 [PMID: 24406217]
  112. Biochim Biophys Acta. 1995 Sep 13;1238(2):147-55 [PMID: 7548129]
  113. Biomacromolecules. 2013 Mar 11;14(3):841-53 [PMID: 23394107]
  114. Org Biomol Chem. 2015 Aug 7;13(29):8067-70 [PMID: 26134592]
  115. Angew Chem Int Ed Engl. 2016 May 23;55(22):6476-81 [PMID: 27079747]
  116. Chem Soc Rev. 2016 Mar 7;45(5):1457-501 [PMID: 26776487]
  117. Biochim Biophys Acta. 1992 Aug 14;1113(2):171-99 [PMID: 1510996]
  118. Langmuir. 2007 Mar 27;23(7):4019-25 [PMID: 17319706]
  119. J Neurooncol. 2012 Aug;109(1):143-8 [PMID: 22539243]
  120. Curr Pharm Des. 2001 Sep;7(14):1327-51 [PMID: 11472272]
  121. J Control Release. 2016 Jan 28;222:56-66 [PMID: 26682502]
  122. Biochemistry. 1985 Mar 26;24(7):1646-53 [PMID: 3839132]
  123. J Control Release. 2014 Nov 10;193:2-8 [PMID: 25037017]
  124. ScientificWorldJournal. 2013;2013:903234 [PMID: 23431260]
  125. Clin Cancer Res. 2007 May 1;13(9):2722-7 [PMID: 17473205]
  126. Chem Commun (Camb). 2010 Aug 7;46(29):5265-7 [PMID: 20411203]
  127. Chem Soc Rev. 2006 Mar;35(3):209-17 [PMID: 16505915]
  128. Adv Drug Deliv Rev. 2012 Aug;64(11):1005-20 [PMID: 22386560]
  129. J Control Release. 2012 Jun 10;160(2):117-34 [PMID: 22484195]
  130. Mol Pharm. 2016 Jan 4;13(1):55-64 [PMID: 26567985]
  131. Int J Pharm. 2015 Oct 15;494(1):172-9 [PMID: 26283281]
  132. Curr Pharm Des. 2013;19(41):7169-84 [PMID: 23489197]
  133. Nanotoxicology. 2011 Dec;5(4):622-35 [PMID: 21261456]
  134. Biotechnol Adv. 2014 Jul-Aug;32(4):693-710 [PMID: 24309541]
  135. ACS Appl Mater Interfaces. 2016 May 25;8(20):12661-73 [PMID: 27145021]
  136. Adv Drug Deliv Rev. 2001 Dec 31;53(3):273-84 [PMID: 11744172]
  137. Ann Oncol. 2000 Jan;11(1):69-72 [PMID: 10690390]
  138. J Control Release. 2009 Nov 16;140(1):55-60 [PMID: 19616596]
  139. J Biomed Nanotechnol. 2012 Apr;8(2):229-39 [PMID: 22515074]
  140. Int J Pharm. 2012 Oct 15;436(1-2):786-97 [PMID: 22884831]
  141. J Control Release. 2008 Mar 20;126(3):187-204 [PMID: 18261822]
  142. Colloids Surf B Biointerfaces. 2015 Feb 1;126:569-74 [PMID: 25481686]
  143. Bioconjug Chem. 2011 Oct 19;22(10):1909-15 [PMID: 21859153]
  144. Int J Pharm. 2015 May 15;485(1-2):374-82 [PMID: 25776453]
  145. Pharm Res. 1994 Aug;11(8):1180-5 [PMID: 7971721]
  146. Breast. 2009 Aug;18(4):218-24 [PMID: 19656681]
  147. Langmuir. 2014 May 20;30(19):5628-36 [PMID: 24787243]
  148. Nanoscale. 2017 Jan 26;9(4):1356-1392 [PMID: 28067384]
  149. J Am Chem Soc. 2017 Apr 5;139(13):4584-4610 [PMID: 28192672]
  150. J Am Chem Soc. 2007 Aug 8;129(31):9572-3 [PMID: 17636919]
  151. Chemistry. 2008;14(21):6490-7 [PMID: 18537211]
  152. J Am Chem Soc. 2008 Jul 2;130(26):8175-7 [PMID: 18543914]
  153. Langmuir. 2004 Jul 20;20(15):6100-6 [PMID: 15248690]
  154. Arch Pharm Res. 2016 Mar;39(3):350-8 [PMID: 26781980]
  155. Int J Pharm. 2000 Jan 5;193(2):157-66 [PMID: 10606778]
  156. Nanoscale Res Lett. 2013 Feb 22;8(1):102 [PMID: 23432972]
  157. Biochim Biophys Acta. 1987 Nov 27;905(1):30-8 [PMID: 3676312]
  158. J Control Release. 2014 Jan 10;173:43-50 [PMID: 24511611]
  159. Colloids Surf B Biointerfaces. 2015 May 1;129:175-82 [PMID: 25851582]
  160. Adv Drug Deliv Rev. 2014 Jun;72:49-64 [PMID: 24270006]
  161. Antimicrob Agents Chemother. 2004 Mar;48(3):1047-50 [PMID: 14982807]
  162. Ther Deliv. 2013 Sep;4(9):1099-123 [PMID: 24024511]
  163. Life Sci. 2007 Jan 23;80(7):659-64 [PMID: 17141809]
  164. J Liposome Res. 2013 Mar;23(1):37-46 [PMID: 23363303]
  165. Sci Rep. 2015 May 12;5:9874 [PMID: 25962872]
  166. Biochim Biophys Acta. 2011 Jan;1808(1):117-26 [PMID: 20691151]
  167. Langmuir. 2010 Jan 19;26(2):709-15 [PMID: 19627165]
  168. Am J Ophthalmol. 2001 Apr;131(4):518-20 [PMID: 11292425]
  169. Chem Phys Lipids. 2009 Nov;162(1-2):1-16 [PMID: 19703435]
  170. Int J Nanomedicine. 2013;8:1573-93 [PMID: 23637529]
  171. Int J Pharm. 2002 Apr 26;237(1-2):129-37 [PMID: 11955811]
  172. Adv Drug Deliv Rev. 2014 Jun;72:82-93 [PMID: 24486388]
  173. Clin Cancer Res. 1999 Nov;5(11):3394-402 [PMID: 10589750]
  174. Adv Drug Deliv Rev. 2004 Apr 23;56(7):947-65 [PMID: 15066754]
  175. Prog Lipid Res. 2000 Sep;39(5):409-60 [PMID: 11082506]
  176. Biomaterials. 2014 Dec;35(36):9731-45 [PMID: 25189519]
  177. Adv Drug Deliv Rev. 2014 Jun;72:110-26 [PMID: 24524934]
  178. J Control Release. 2002 Sep 18;83(1):121-32 [PMID: 12220844]
  179. Cancer Res. 2000 Dec 15;60(24):6950-7 [PMID: 11156395]
  180. J Liposome Res. 2016 Dec;26(4):276-87 [PMID: 26784587]
  181. Nanomedicine (Lond). 2016;11(5):513-30 [PMID: 26906471]
  182. Drug Deliv. 2015 May;22(3):231-42 [PMID: 24524308]
  183. J Control Release. 2015 Apr 10;203:85-98 [PMID: 25701610]
  184. Colloids Surf B Biointerfaces. 2014 Sep 1;121:248-56 [PMID: 25001189]
  185. Int J Nanomedicine. 2016 Nov 01;11:5697-5708 [PMID: 27843312]
  186. J Control Release. 2002 Apr 23;80(1-3):309-19 [PMID: 11943407]
  187. Nat Rev Drug Discov. 2005 Feb;4(2):145-60 [PMID: 15688077]

Grants

  1. R01 AI050875/NIAID NIH HHS
  2. R21 AI121700/NIAID NIH HHS
Journal Article

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