OpenLB
Open Library of Bioscience
Advanced Search
Nature reviews. Cancer
04, 2018;18 (4): 224-239.

From genetics to the clinic: a translational perspective on follicular lymphoma.

Sarah Huet, Pierre Sujobert, Gilles Salles
Author Information
  1. Sarah Huet: Cancer Research Center of Lyon, INSERM 1052 CNRS5286, 'Clinical and experimental models of lymphomagenesis' Team, Equipe labellisée Ligue Contre le Cancer Oullins, France.
  2. Pierre Sujobert: Cancer Research Center of Lyon, INSERM 1052 CNRS5286, 'Clinical and experimental models of lymphomagenesis' Team, Equipe labellisée Ligue Contre le Cancer Oullins, France.
  3. Gilles Salles: Cancer Research Center of Lyon, INSERM 1052 CNRS5286, 'Clinical and experimental models of lymphomagenesis' Team, Equipe labellisée Ligue Contre le Cancer Oullins, France.
PMID: 29422597 DOI: 10.1038/nrc.2017.127

Abstract

Follicular lymphoma (FL) is the most frequent indolent B cell lymphoma and is still considered to be incurable. In recent years, whole-exome sequencing studies of large cohorts of patients have greatly improved our knowledge of the FL mutational landscape. Moreover, the prolonged evolution of this disease has enabled some insights regarding the early pre-lymphoma lesions as well as the clonal evolution after treatment, allowing an evolutionary perspective on lymphomagenesis. Deciphering the earliest initiating lesions and identifying the molecular alterations leading to disease progression currently represent important goals; accomplishing these could help identify the most relevant targets for precision therapy.

References

  1. Cancer Cell. 2013 May 13;23 (5):677-92 [PMID: 23680150]
  2. J Clin Invest. 2014 Dec;124(12):5337-51 [PMID: 25384217]
  3. J Clin Oncol. 2010 Feb 10;28(5):822-9 [PMID: 20026809]
  4. Am J Hematol. 2016 Nov;91(11):1096-1101 [PMID: 27465588]
  5. J Clin Oncol. 2008 Nov 10;26(32):5165-9 [PMID: 18838711]
  6. N Engl J Med. 1988 May 26;318(21):1373-8 [PMID: 3285208]
  7. Blood. 2017 Jan 26;129(4):473-483 [PMID: 28064239]
  8. Clin Cancer Res. 2017 Feb 15;23 (4):885-893 [PMID: 27881582]
  9. Haematologica. 2013 Oct;98(10):1571-80 [PMID: 23831923]
  10. Blood. 2017 May 11;129(19):2645-2656 [PMID: 28288979]
  11. Nature. 2011 Mar 10;471(7337):189-95 [PMID: 21390126]
  12. Blood. 2016 Aug 25;128(8):1101-11 [PMID: 27257180]
  13. Blood. 2009 Oct 8;114(15):3158-66 [PMID: 19636063]
  14. Int Immunol. 2010 Nov;22(11):875-87 [PMID: 21059768]
  15. Nat Cell Biol. 2017 Sep;19(9):1093-1104 [PMID: 28825697]
  16. J Clin Oncol. 2017 Mar 10;35(8):826-833 [PMID: 28095146]
  17. Blood. 2009 Nov 19;114(21):4713-20 [PMID: 19786615]
  18. Blood. 2002 May 1;99(9):3376-82 [PMID: 11964306]
  19. Blood Cancer J. 2017 Apr 21;7(4):e555 [PMID: 28430172]
  20. Cancer Discov. 2012 Jan;2(1):47-55 [PMID: 22585168]
  21. Leukemia. 2009 Oct;23(10):1858-66 [PMID: 19587707]
  22. Science. 2007 Apr 13;316(5822):295-8 [PMID: 17363629]
  23. J Immunol. 2013 May 1;190(9):4887-98 [PMID: 23536634]
  24. Science. 2008 Mar 21;319(5870):1676-9 [PMID: 18323416]
  25. Front Immunol. 2013 Dec 30;4:500 [PMID: 24416036]
  26. Blood. 2014 Feb 13;123(7):1051-4 [PMID: 24357726]
  27. Blood. 1998 Apr 15;91(8):2977-84 [PMID: 9531609]
  28. PLoS Med. 2016 Dec 13;13(12 ):e1002197 [PMID: 27959929]
  29. J Clin Oncol. 1997 Apr;15(4):1587-94 [PMID: 9193357]
  30. Haematologica. 2014 May;99(5):802-10 [PMID: 24790058]
  31. Blood. 1998 Oct 15;92(8):2871-8 [PMID: 9763572]
  32. Br J Haematol. 2007 Aug;138(3):349-53 [PMID: 17614821]
  33. Clin Cancer Res. 2016 Nov 1;22(21):5383-5393 [PMID: 27267853]
  34. Blood. 2016 May 19;127(20):2375-90 [PMID: 26980727]
  35. Cell. 2007 Sep 21;130(6):986-8 [PMID: 17889643]
  36. Nat Rev Immunol. 2015 Mar;15(3):137-48 [PMID: 25656706]
  37. Hematol Oncol. 2017 Dec;35(4):397-407 [PMID: 28378425]
  38. Proc Natl Acad Sci U S A. 2015 Mar 10;112(10 ):E1116-25 [PMID: 25713363]
  39. Oncotarget. 2017 Jan 31;8(5):8765-8774 [PMID: 28060738]
  40. Nature. 2003 Apr 17;422(6933):730-4 [PMID: 12700764]
  41. Sci Transl Med. 2016 Nov 9;8(364):364ra155 [PMID: 27831904]
  42. Nat Med. 2015 Oct;21(10):1190-8 [PMID: 26366712]
  43. Nat Genet. 2010 Aug;42(8):661-4 [PMID: 20639881]
  44. Blood. 2014 Mar 13;123(11):1699-708 [PMID: 24385541]
  45. Blood. 2015 Oct 15;126(16):1911-20 [PMID: 26272216]
  46. Cancer Discov. 2017 May;7(5):506-521 [PMID: 28232365]
  47. Nat Cell Biol. 2008 Aug;10(8):935-45 [PMID: 18604198]
  48. Expert Rev Hematol. 2015 Apr;8(2):187-203 [PMID: 25585961]
  49. Br J Haematol. 2017 Jun;177(5):684-702 [PMID: 28146265]
  50. J Clin Oncol. 2016 Aug 1;34(22):2566-7 [PMID: 27298400]
  51. Blood. 2006 Jun 1;107(11):4407-16 [PMID: 16424387]
  52. Am J Hematol. 2017 Jun;92 (6):515-519 [PMID: 28247997]
  53. Leukemia. 2015 Feb;29(2):456-63 [PMID: 25027518]
  54. Nat Biotechnol. 2016 May;34(5):547-555 [PMID: 27018799]
  55. Curr Opin Hematol. 2016 Jul;23 (4):377-84 [PMID: 27055146]
  56. Blood. 2012 Nov 15;120(20):4182-90 [PMID: 23024238]
  57. J Exp Med. 2010 Jan 18;207(1):17-27 [PMID: 20026661]
  58. Cell. 2011 Oct 28;147(3):554-64 [PMID: 22036564]
  59. Int J Cancer. 2009 Feb 15;124(4):958-63 [PMID: 19030176]
  60. Lancet Oncol. 2015 Sep;16(9):1111-1122 [PMID: 26256760]
  61. Cancer Discov. 2017 Jan;7(1):38-53 [PMID: 27733359]
  62. Clin Cancer Res. 2014 Oct 15;20(20):5226-39 [PMID: 25320372]
  63. Nat Immunol. 2009 Dec;10(12):1292-9 [PMID: 19855380]
  64. Genes Chromosomes Cancer. 1998 Jan;21(1):17-29 [PMID: 9443038]
  65. Blood. 2006 May 1;107(9):3639-46 [PMID: 16403912]
  66. Blood. 2011 Sep 15;118(11):2976-84 [PMID: 21768298]
  67. Blood. 2013 Oct 31;122(18):3165-8 [PMID: 24052547]
  68. Cancer Res. 2010 Nov 15;70(22):9166-74 [PMID: 20884631]
  69. J Clin Oncol. 2007 Feb 1;25(4):390-8 [PMID: 17200149]
  70. Nature. 2015 Mar 26;519(7544):477-81 [PMID: 25561175]
  71. J Clin Oncol. 2014 May 1;32(13):1347-55 [PMID: 24687831]
  72. Biochemistry. 2010 Sep 28;49(38):8240-50 [PMID: 20799731]
  73. Am J Hum Genet. 2014 Oct 2;95(4):462-71 [PMID: 25279986]
  74. Semin Cancer Biol. 2014 Feb;24:23-32 [PMID: 23978491]
  75. Nat Rev Drug Discov. 2013 Mar;12(3):229-43 [PMID: 23449308]
  76. Nat Rev Cancer. 2014 Aug;14(8):517-34 [PMID: 25008267]
  77. Nature. 2014 Dec 11;516(7530):254-8 [PMID: 25274307]
  78. Mol Immunol. 2008 Mar;45(6):1567-72 [PMID: 18022232]
  79. Blood. 2015 Jan 22;125(4):668-79 [PMID: 25428220]
  80. Cancer Cell. 2005 May;7(5):445-55 [PMID: 15894265]
  81. PLoS Genet. 2013;9(1):e1003137 [PMID: 23326238]
  82. Blood. 2016 Jun 2;127(22):2723-31 [PMID: 26989201]
  83. Blood. 1993 Oct 1;82(7):1994-2004 [PMID: 8400252]
  84. Immunol Rev. 2012 May;247(1):172-83 [PMID: 22500840]
  85. Nat Commun. 2015 Aug 06;6:7953 [PMID: 26245647]
  86. Cancer Discov. 2017 Mar;7(3):322-337 [PMID: 28069569]
  87. Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):12747-54 [PMID: 20543139]
  88. N Engl J Med. 2004 Nov 18;351(21):2159-69 [PMID: 15548776]
  89. Nature. 1988 Sep 29;335(6189):440-2 [PMID: 3262202]
  90. Nat Genet. 2015 Nov;47(11):1316-1325 [PMID: 26437030]
  91. Blood. 2003 Aug 15;102(4):1443-8 [PMID: 12738680]
  92. Cell. 2010 Apr 16;141(2):290-303 [PMID: 20381137]
  93. Nat Genet. 2010 Feb;42(2):181-5 [PMID: 20081860]
  94. Blood. 2008 Jun 15;111(12):5433-9 [PMID: 18272816]
  95. Semin Cancer Biol. 2013 Dec;23(6):422-30 [PMID: 23665546]
  96. Cell Rep. 2014 Jan 16;6(1):130-40 [PMID: 24388756]
  97. Genome Biol. 2015 Apr 23;16:84 [PMID: 25903198]
  98. J Mol Diagn. 2014 Jul;16(4):467-76 [PMID: 24814955]
  99. Cell Rep. 2015 Sep 29;12(12):2086-98 [PMID: 26365193]
  100. Blood. 2014 Mar 13;123(11):1681-90 [PMID: 24037725]
  101. Blood. 2003 Apr 15;101(8):3109-17 [PMID: 12406872]
  102. Nat Rev Cancer. 2005 Sep;5(9):689-98 [PMID: 16110319]
  103. Leuk Lymphoma. 2003;44 Suppl 3:S5-12 [PMID: 15202519]
  104. J Clin Invest. 2013 Dec;123(12 ):5009-22 [PMID: 24200695]
  105. Nat Rev Mol Cell Biol. 2011 Jan;12(1):21-35 [PMID: 21157483]
  106. Nat Immunol. 2011 Jun 05;12(7):672-80 [PMID: 21642988]
  107. Nat Genet. 2014 Feb;46(2):176-181 [PMID: 24362818]
  108. Blood. 2007 Oct 1;110(7):2537-44 [PMID: 17615291]
  109. Haematologica. 2014 Mar;99(3):481-8 [PMID: 24162788]
  110. Mol Cell Biol. 2013 Mar;33(5):947-57 [PMID: 23263985]
  111. Blood. 2009 Apr 9;113(15):3553-7 [PMID: 19202129]
  112. N Engl J Med. 1982 Nov 11;307(20):1231-6 [PMID: 7133054]
  113. Leukemia. 2017 Jan;31(1):83-91 [PMID: 27389057]
  114. J Intern Med. 2017 Nov;282(5):415-428 [PMID: 28295729]
  115. Blood. 2012 Mar 15;119(11):2556-67 [PMID: 22289889]
  116. Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18587-92 [PMID: 20937880]
  117. Blood. 1993 Oct 15;82(8):2289-95 [PMID: 8400281]
  118. J Clin Oncol. 2017 Dec 10;35(35):3898-3905 [PMID: 28976790]
  119. Science. 1985 Jun 21;228(4706):1440-3 [PMID: 3874430]
  120. Cell Rep. 2013 Aug 15;4(3):578-88 [PMID: 23911289]
  121. J Exp Med. 2007 Oct 29;204(11):2655-65 [PMID: 17938234]
  122. Nat Rev Cancer. 2017 Mar;17 (3):145-159 [PMID: 28154375]
  123. Cancer Cell. 2016 Aug 8;30(2):197-213 [PMID: 27505670]
  124. J Clin Oncol. 2016 Aug 1;34(22):2575-82 [PMID: 27298402]
  125. Immunol Rev. 2009 May;229(1):244-58 [PMID: 19426226]
  126. Blood. 2017 Jul 20;130(3):323-327 [PMID: 28533310]
  127. J Exp Med. 2006 Oct 30;203(11):2425-31 [PMID: 17043145]
  128. J Clin Oncol. 2015 Aug 10;33(23):2516-22 [PMID: 26124482]
  129. Blood. 2015 Oct 15;126(16):1902-10 [PMID: 26194765]
  130. Blood. 2017 May 4;129(18):2507-2518 [PMID: 28202459]
  131. Blood Adv. 2017 Sep 27;1(22):1884-1890 [PMID: 29296835]
  132. Nat Rev Immunol. 2006 Sep;6(9):671-81 [PMID: 16932752]
  133. Science. 1985 Sep 27;229(4720):1390-3 [PMID: 3929382]
  134. Leukemia. 2014 May;28(5):1103-12 [PMID: 24153014]
  135. Nat Genet. 2016 Feb;48(2):183-8 [PMID: 26691987]
  136. Leuk Lymphoma. 2015;56(12):3257-66 [PMID: 26044172]
  137. Nat Rev Cancer. 2005 Apr;5(4):251-62 [PMID: 15803153]
  138. Cell. 2008 Dec 12;135(6):1130-42 [PMID: 19070581]
  139. Nat Genet. 2014 Feb;46(2):166-70 [PMID: 24413734]
  140. Nat Med. 2014 Dec;20(12):1472-8 [PMID: 25326804]
  141. Nat Rev Immunol. 2015 Mar;15(3):172-84 [PMID: 25712152]
  142. Blood. 2013 Feb 28;121(9):1604-11 [PMID: 23297126]
  143. Nat Med. 2015 Oct;21(10):1199-208 [PMID: 26366710]
  144. Haematologica. 2013 Sep;98(9):1433-41 [PMID: 23585531]
  145. J Clin Oncol. 2010 Nov 1;28(31):4740-6 [PMID: 20837940]
  146. Science. 2011 Mar 4;331(6021):1203-7 [PMID: 21310965]
  147. Blood. 2009 Nov 12;114(20):4503-6 [PMID: 19734449]
  148. Nat Genet. 2015 Jul;47(7):746-56 [PMID: 26053498]
  149. Leukemia. 2010 Dec;24(12):2080-9 [PMID: 20944673]
  150. Blood. 2017 Jul 20;130(3):258-266 [PMID: 28408460]
  151. Blood. 2013 May 2;121(18):3563-72 [PMID: 23640996]
  152. Haematologica. 2017 Apr;102(4):e156-e159 [PMID: 27979923]
  153. Hum Immunol. 2017 Feb;78(2):138-145 [PMID: 27693433]
  154. Blood. 2016 Apr 28;127(17 ):2055-63 [PMID: 26989204]
  155. Lancet Oncol. 2018 Feb 20;:null [PMID: 29475724]
  156. Science. 2011 Nov 4;334(6056):678-83 [PMID: 22053050]
  157. Adv Immunol. 2011;111:1-46 [PMID: 21970951]
  158. Leuk Lymphoma. 2014 Nov;55(11):2502-7 [PMID: 24450580]
  159. Blood. 2002 Apr 1;99(7):2562-8 [PMID: 11895794]
  160. Blood. 2015 Oct 29;126(18):2118-27 [PMID: 26307535]
  161. Trends Mol Med. 2014 Jun;20(6):343-52 [PMID: 24698494]
  162. Blood. 2014 Mar 6;123(10 ):1487-98 [PMID: 24435047]
  163. J Clin Oncol. 2013 Sep 10;31(26):3272-8 [PMID: 23897955]
  164. Cell. 2016 Oct 6;167(2):405-418.e13 [PMID: 27693350]
  165. Nat Med. 2015 Dec;21(12 ):1491-6 [PMID: 26552009]
  166. Blood. 1995 May 1;85(9):2528-36 [PMID: 7727781]
  167. Epigenetics. 2017 May 4;12 (5):370-377 [PMID: 28106467]
  168. Cancer Discov. 2013 Sep;3(9):1002-19 [PMID: 23955273]
  169. Cancer Res. 2009 Jul 1;69(13):5522-30 [PMID: 19509224]
  170. Am J Pathol. 2016 Dec;186(12 ):3273-3284 [PMID: 27750045]
  171. J Biol Chem. 2007 Mar 9;282(10):7405-15 [PMID: 17197448]
  172. Blood. 2016 Aug 25;128(8):1093-100 [PMID: 27325104]
  173. Nat Genet. 2009 Aug;41(8):873-5 [PMID: 19620980]
  174. Nat Rev Cancer. 2017 Apr;17 (4):223-238 [PMID: 28233803]
  175. Nat Immunol. 2013 Oct;14(10):1084-92 [PMID: 23974956]
  176. J Clin Oncol. 1996 Apr;14(4):1333-44 [PMID: 8648392]
  177. BMC Genomics. 2012 Oct 01;13:516 [PMID: 23025665]
  178. Lancet. 2011 Jan 1;377(9759):42-51 [PMID: 21176949]
  179. Nat Med. 2014 May;20(5):548-54 [PMID: 24705333]
  180. Nat Immunol. 2013 Apr;14(4):380-8 [PMID: 23455674]
  181. Leukemia. 2014 Sep;28(9):1937-40 [PMID: 24850291]
  182. Nature. 2011 Jul 27;476(7360):298-303 [PMID: 21796119]
  183. Leukemia. 2012 Mar;26(3):559-62 [PMID: 21941365]
  184. J Pathol. 2014 Nov;234(3):423-30 [PMID: 25141821]
  185. Blood. 2008 Sep 1;112(5):1951-9 [PMID: 18515657]
  186. Immunity. 2015 Jan 20;42(1):186-98 [PMID: 25607463]
  187. Blood. 2014 May 29;123(22):3462-5 [PMID: 24677543]

MeSH Term

Antineoplastic Agents
Cell Proliferation
Cell Survival
Chromatin
DNA Methylation
Epigenesis, Genetic
Humans
Immune Evasion
Lymphoma, Follicular
Molecular Targeted Therapy
Mutation
Translational Research, Biomedical

Chemicals

Antineoplastic Agents
Chromatin
Journal Article Review
Article has an altmetric score of 28

Word Cloud

Created with Highcharts 10.0.0lymphomaFLevolutiondiseaselesionsperspectiveFollicularfrequentindolentBcellstillconsideredincurablerecentyearswhole-exomesequencingstudieslargecohortspatientsgreatlyimprovedknowledgemutationallandscapeMoreoverprolongedenabledinsightsregardingearlypre-lymphomawellclonaltreatmentallowingevolutionarylymphomagenesisDecipheringearliestinitiatingidentifyingmolecularalterationsleadingprogressioncurrentlyrepresentimportantgoalsaccomplishinghelpidentifyrelevanttargetsprecisiontherapygeneticsclinic:translationalfollicular

Similar Articles

Cited By