Comparison of Eye Movement Desensitization Reprocessing and Cognitive Behavioral Therapy as Adjunctive Treatments for Recurrent Depression: The European Depression EMDR Network (EDEN) Randomized Controlled Trial.
Luca Ostacoli, Sara Carletto, Marco Cavallo, Paula Baldomir-Gago, Giorgio Di Lorenzo, Isabel Fernandez, Michael Hase, Ania Justo-Alonso, Maria Lehnung, Giuseppe Migliaretti, Francesco Oliva, Marco Pagani, Susana Recarey-Eiris, Riccardo Torta, Visal Tumani, Ana I Gonzalez-Vazquez, Arne Hofmann
Author Information
Luca Ostacoli: Clinical and Biological Sciences Department, University of Turin, Turin, Italy.
Sara Carletto: Clinical and Biological Sciences Department, University of Turin, Turin, Italy.
Marco Cavallo: eCampus University, Novedrate, Italy.
Paula Baldomir-Gago: Centro INTRA-TP, A Coruña, Spain.
Giorgio Di Lorenzo: Laboratory of Psychophysiology, Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
Treatment of recurrent depressive disorders is currently only moderately successful. Increasing evidence suggests a significant relationship between adverse childhood experiences and recurrent depressive disorders, suggesting that trauma-based interventions could be useful for these patients. To investigate the efficacy of Eye Movement Desensitization and Reprocessing therapy (EMDR) in addition to antidepressant medication (ADM) in treating recurrent depression. A non-inferiority, single-blind, randomized clinical controlled trial comparing EMDR or CBT as adjunctive treatments to ADM. Randomization was carried out by a central computer system. Allocation was carried out by a study coordinator in each center. Two psychiatric services, one in Italy and one in Spain. Eighty-two patients were randomized with a 1:1 ratio to the EMDR group ( = 40) or CBT group ( = 42). Sixty-six patients, 31 in the EMDR group and 35 in the CBT group, were included in the completers analysis. 15 ± 3 individual sessions of EMDR or CBT, both in addition to ADM. Participants were followed up at 6-months. : Rate of depressive symptoms remission in both groups, as measured by a BDI-II score <13. Sixty-six patients were analyzed as completers (31 EMDR vs. 35 CBT). No significant difference between the two groups was found either at the end of the interventions (71% EMDR vs. 48.7% CBT) or at the 6-month follow-up (54.8% EMDR vs. 42.9% CBT). A RM-ANOVA on BDI-II scores showed similar reductions over time in both groups [(6,59) = 22.501, < 0.001] and a significant interaction effect between time and group [(6,59) = 3.357, = 0.006], with lower BDI-II scores in the EMDR group at T1 [mean difference = -7.309 (95% CI [-12.811, -1.806]), 0.010]. The RM-ANOVA on secondary outcome measures showed similar improvement over time in both groups [(14,51) = 8.202, < 0.001], with no significant differences between groups [(614,51) = 0.642, = 0.817]. Although these results can be considered preliminary only, this study suggests that EMDR could be a viable and effective treatment for reducing depressive symptoms and improving the quality of life of patients with recurrent depression. TRIAL REGISTRATION: ISRCTN09958202.
