OpenLB
Open Library of Bioscience
Advanced Search
eLife
02 28, 2018;7

Shorter cortical adaptation in dyslexia is broadly distributed in the superior temporal lobe and includes the primary auditory cortex.

Sagi Jaffe-Dax, Eva Kimel, Merav Ahissar
Author Information
  1. Sagi Jaffe-Dax: Department of Psychology, Princeton University, Princeton, United States. ORCID
  2. Eva Kimel: The Edmond and Lily Safra Center for Brain Sciences, Hebrew University of Jerusalem, Jerusalem, Israel.
  3. Merav Ahissar: The Edmond and Lily Safra Center for Brain Sciences, Hebrew University of Jerusalem, Jerusalem, Israel.
PMID: 29488880 DOI: 10.7554/eLife.30018

Abstract

Studies of the performance of individuals with dyslexia in perceptual tasks suggest that their implicit inference of sound statistics is impaired. Previously, using two-tone frequency discrimination, we found that the effect of previous trials' frequencies on the judgments of individuals with dyslexia decays faster than the effect on controls' judgments, and that the adaptation (decrease of neural response to repeated stimuli) of their ERP responses to tones is shorter (Jaffe-Dax et al., 2017). Here, we show the cortical distribution of these abnormal dynamics of adaptation using fast-acquisition fMRI. We find that faster decay of adaptation in dyslexia is widespread, although the most significant effects are found in the left superior temporal lobe, including the auditory cortex. This broad distribution suggests that the faster decay of implicit memory of individuals with dyslexia is a general characteristic of their cortical dynamics, which also affects sensory cortices.

Keywords

adaptation dyslexia fMRI human implicit memory neuroscience

References

  1. Brain Lang. 2007 Jul;102(1):80-90 [PMID: 16887180]
  2. Proc Biol Sci. 1996 Aug 22;263(1373):961-5 [PMID: 8805833]
  3. Hum Brain Mapp. 2006 May;27(5):392-401 [PMID: 16596654]
  4. J Neurosci. 2015 Sep 2;35(35):12116-26 [PMID: 26338323]
  5. Science. 1992 Dec 4;258(5088):1668-70 [PMID: 1455246]
  6. Magn Reson Med. 2010 May;63(5):1144-53 [PMID: 20432285]
  7. Trends Cogn Sci. 2011 Jan;15(1):3-10 [PMID: 21093350]
  8. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):E6233-42 [PMID: 26504238]
  9. Science. 2011 Jul 29;333(6042):595 [PMID: 21798942]
  10. Nat Neurosci. 2005 Jul;8(7):862-3 [PMID: 15924138]
  11. PLoS Comput Biol. 2012;8(10):e1002731 [PMID: 23133343]
  12. Nat Neurosci. 2003 Feb;6(2):190-5 [PMID: 12496761]
  13. Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16428-33 [PMID: 21885736]
  14. Trends Cogn Sci. 2007 Nov;11(11):458-65 [PMID: 17983834]
  15. Audiol Neurootol. 1998 Mar-Jun;3(2-3):191-213 [PMID: 9575385]
  16. Neuroimage. 2001 Apr;13(4):684-701 [PMID: 11305897]
  17. Neuroimage. 2010 Jan 1;49(1):849-64 [PMID: 19591945]
  18. Science. 2013 Dec 6;342(6163):1251-4 [PMID: 24311693]
  19. Neuroimage. 1998 Jan;7(1):30-40 [PMID: 9500830]
  20. Magn Reson Med. 1995 May;33(5):636-47 [PMID: 7596267]
  21. Child Dev. 1985 Dec;56(6):1404-17 [PMID: 3878269]
  22. J Neurophysiol. 2010 Aug;104(2):1177-94 [PMID: 20410363]
  23. J Neurosci. 2012 Nov 14;32(46):16095-105 [PMID: 23152594]
  24. Neuron. 2016 Dec 21;92 (6):1383-1397 [PMID: 28009278]
  25. Neuroimage. 2008 Aug 15;42(2):717-25 [PMID: 18572418]
  26. Cereb Cortex. 2015 Nov;25(11):4596-609 [PMID: 26048954]
  27. Nat Neurosci. 2006 Dec;9(12):1558-64 [PMID: 17115044]
  28. Nat Neurosci. 2000 Feb;3(2):184-90 [PMID: 10649575]
  29. Curr Biol. 1998 Jul 2;8(14):791-7 [PMID: 9663387]
  30. J Cogn Neurosci. 2015 Jul;27(7):1308-21 [PMID: 25603023]
  31. Front Hum Neurosci. 2017 Jul 26;11:384 [PMID: 28798673]
  32. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6832-7 [PMID: 10841578]
  33. Front Hum Neurosci. 2013 Aug 09;7:454 [PMID: 23950742]
  34. Neuropsychologia. 2012 Jul;50(8):1895-905 [PMID: 22561890]
  35. Curr Opin Neurobiol. 2013 Feb;23(1):37-42 [PMID: 23040541]
  36. Brain. 2014 Dec;137(Pt 12):3136-41 [PMID: 25125610]
  37. J Vis. 2016 Jul 1;16(9):10 [PMID: 27472497]
  38. Elife. 2017 Jan 24;6:null [PMID: 28115055]
  39. PLoS Comput Biol. 2014 Dec 04;10(12):e1003948 [PMID: 25474117]

Grants

  1. /CIHR

MeSH Term

Adaptation, Physiological
Adult
Auditory Cortex
Auditory Perception
Dyslexia
Female
Humans
Magnetic Resonance Imaging
Male
Temporal Lobe
Young Adult
Journal Article Research Support, Non-U.S. Gov't
Article has an altmetric score of 4

Word Cloud

Created with Highcharts 10.0.0dyslexiaadaptationindividualsimplicitfastercorticalusingfoundeffectjudgmentsdistributiondynamicsfMRIdecaysuperiortemporallobeauditorycortexmemoryStudiesperformanceperceptualtaskssuggestinferencesoundstatisticsimpairedPreviouslytwo-tonefrequencydiscriminationprevioustrials'frequenciesdecayscontrols'decreaseneuralresponserepeatedstimuliERPresponsestonesshorterref-type="bibr"rid="bib22">Jaffe-Daxetal2017showabnormalfast-acquisitionfindwidespreadalthoughsignificanteffectsleftincludingbroadsuggestsgeneralcharacteristicalsoaffectssensorycorticesShorterbroadlydistributedincludesprimaryhumanneuroscience

Similar Articles

Cited By