Maternal Exposures Associated with Autism Spectrum Disorder in Jamaican Children.
MacKinsey A Christian, Maureen Samms-Vaughan, MinJae Lee, Jan Bressler, Manouchehr Hessabi, Megan L Grove, Sydonnie Shakespeare-Pellington, Charlene Coore Desai, Jody-Ann Reece, Katherine A Loveland, Eric Boerwinkle, Mohammad H Rahbar
Author Information
MacKinsey A Christian: Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Maureen Samms-Vaughan: Department of Child and Adolescent Health, The University of the West Indies (UWI), Mona Campus, Kingston, Jamaica.
MinJae Lee: Biostatistics/Epidemiology/Research Design (BERD) core, Center for Clinical and Translational Sciences (CCTS), The University of Texas Health Science Center at Houston, Houston, TX, USA.
Jan Bressler: Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Manouchehr Hessabi: Biostatistics/Epidemiology/Research Design (BERD) core, Center for Clinical and Translational Sciences (CCTS), The University of Texas Health Science Center at Houston, Houston, TX, USA.
Megan L Grove: Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Sydonnie Shakespeare-Pellington: Department of Child and Adolescent Health, The University of the West Indies (UWI), Mona Campus, Kingston, Jamaica.
Charlene Coore Desai: Department of Child and Adolescent Health, The University of the West Indies (UWI), Mona Campus, Kingston, Jamaica.
Jody-Ann Reece: Department of Child and Adolescent Health, The University of the West Indies (UWI), Mona Campus, Kingston, Jamaica.
Katherine A Loveland: Department of Psychiatry and Behavioral Sciences, The University of Texas McGovern Medical School, Houston, TX, USA.
Eric Boerwinkle: Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Mohammad H Rahbar: Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA. Mohammad.H.Rahbar@uth.tmc.edu.
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with poorly understood etiology. Many maternal exposures during pregnancy and breastfeeding potentially interfere with neurodevelopment. Using data from two age- and sex-matched case-control studies in Jamaica (n = 298 pairs), results of conditional logistic regression analyses suggest that maternal exposures to fever or infection (matched odds ratio (MOR) = 3.12, 95% CI 1.74-5.60), physical trauma (MOR 2.02, 95% CI 1.01-4.05), and oil-based paints (MOR 1.99, 95% CI 1.14-3.46) may be associated with ASD. Additionally, maternal exposure to oil-based paints may modify the relationship between maternal exposure to pesticides and ASD, which deepens our understanding of the association between pesticides and ASD.
