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2018;13 (3): e0194044.

Genome-wide association analysis identifies multiple loci associated with kidney disease-related traits in Korean populations.

Jeonghwan Lee, Young Lee, Boram Park, Sungho Won, Jin Suk Han, Nam Ju Heo
Author Information
  1. Jeonghwan Lee: Department of Internal Medicine, Hallym University Hangang Sacred Heart Hospital, Seoul, Korea.
  2. Young Lee: Veterans Medical Research Institute, Veterans Health Service Medical Center, Seoul, Korea.
  3. Boram Park: Department of Public Health Science, Seoul National University, Seoul, Korea.
  4. Sungho Won: Department of Public Health Science, Seoul National University, Seoul, Korea.
  5. Jin Suk Han: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
  6. Nam Ju Heo: Division of Nephrology, Department of Internal Medicine, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Korea.
PMID: 29558500 DOI: 10.1371/journal.pone.0194044

Abstract

Chronic kidney disease (CKD) is an important social health problem characterized by a decrease in the kidney glomerular filtration rate (GFR). In this study, we analyzed genome-wide association studies for kidney disease-related traits using data from a Korean adult health screening cohort comprising 7,064 participants. Kidney disease-related traits analyzed include blood urea nitrogen (BUN), serum creatinine, estimated GFR, and uric acid levels. We detected two genetic loci (SLC14A2 and an intergenic region) and 8 single nucleotide polymorphisms (SNPs) associated with BUN, 3 genetic loci (BCAS3, C17orf82, ALDH2) and 6 SNPs associated with serum creatinine, 3 genetic loci (BCAS3, C17orf82/TBX2, LRP2) and 7 SNPs associated with GFR, and 14 genetic loci (3 in ABCG2/PKD2, 2 in SLC2A9, 3 in intergenic regions on chromosome 4; OTUB1, NRXN2/SLC22A12, CDC42BPG, RPS6KA4, SLC22A9, and MAP4K2 on chromosome 11) and 84 SNPs associated with uric acid levels. By comparing significant genetic loci associated with serum creatinine levels and GFR, rs9895661 in BCAS3 and rs757608 in C17orf82 were simultaneously associated with both traits. The SNPs rs11710227 in intergenic regions on chromosome 3 showing significant association with BUN is newly discovered. Genetic variations of multiple gene loci are associated with kidney disease-related traits, and differences in associations between kidney disease-related traits and genetic variation are dependent on the population. The meanings of the mutations identified in this study will need to be reaffirmed in other population groups in the future.

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MeSH Term

Adult
Blood Urea Nitrogen
Chromosomes, Human, Pair 3
Chromosomes, Human, Pair 4
Creatinine
Female
Genetic Loci
Genetic Predisposition to Disease
Genome-Wide Association Study
Glomerular Filtration Rate
Humans
Kidney
Kidney Function Tests
Male
Middle Aged
Polymorphism, Single Nucleotide
Renal Insufficiency, Chronic
Seoul
Uric Acid

Chemicals

Uric Acid
Creatinine
Journal Article Research Support, Non-U.S. Gov't
Article has an altmetric score of 1

Word Cloud

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