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Chromosoma
06, 2018;127 (2): 229-234.

What is behind "centromere repositioning"?

Ingo Schubert
Author Information
  1. Ingo Schubert: Leibniz Institute of Plant Genetics and Crop Pant Research (IPK), D-06466, Gatersleben, Germany. schubert@ipk-gatersleben.de.
PMID: 29705818 DOI: 10.1007/s00412-018-0672-y

Abstract

An increasing number of observations suggest an evolutionary switch of centromere position on monocentric eukaryotic chromosomes which otherwise display a conserved sequence of genes and markers. Such observations are particularly frequent for primates and equidae (for review see Heredity 108:59-67, 2012) but occur also in marsupials (J Hered 96:217-224, 2005) and in plants (Chromosome Res 25:299-311, 2017 and references therein). The actual mechanism(s) behind remained unclear in many cases (Proc Natl Acad Sci USA 101:6542-6547, 2004; Trends Genet 30:66-74, 2014). The same is true for de novo centromere formation on chromosomes lacking an active centromere. This article focuses on recent reports on centromere repositioning and possible mechanisms behind and addresses open questions.

Keywords

CenH3 loading Centromere repositioning DSB mis-repair Dicentric/acentric chromosomes Peri-/paracentric inversion de novo centromere formation

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MeSH Term

Animals
Centromere
Centromere Protein A
Chromosome Segregation
DNA
DNA Repair
DNA Repair-Deficiency Disorders
Eukaryotic Cells
Gene Expression
Humans
Kinetochores
Mitosis
Nucleosomes
Plants
Spindle Apparatus

Chemicals

CENPA protein, human
Centromere Protein A
Nucleosomes
DNA
Journal Article Review
Article has an altmetric score of 5

Word Cloud

Created with Highcharts 10.0.0centromerechromosomesbehindobservationsdenovoformationrepositioningincreasingnumbersuggestevolutionaryswitchpositionmonocentriceukaryoticotherwisedisplayconservedsequencegenesmarkersparticularlyfrequentprimatesequidaereviewseeHeredity108:59-672012occuralsomarsupialsJHered96:217-2242005plantsChromosomeRes25:299-3112017referencesthereinactualmechanismsremainedunclearmanycasesProcNatlAcadSciUSA101:6542-65472004TrendsGenet30:66-742014truelackingactivearticlefocusesrecentreportspossiblemechanismsaddressesopenquestions"centromererepositioning"?CenH3loadingCentromereDSBmis-repairDicentric/acentricPeri-/paracentricinversion

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