Chronic Stress protection for postnatal dEpREssioN prEvention (SERENE): a protocol for an exploratory study.
Dahlia Tharwat, Marion Trousselard, Mélanie Balès, Anne-Laure Sutter-Dallay, Dominique Fromage, Elisabeth Spitz, Dominique Dallay, Thierry Harvey, Eric Welter, Frédéric Coatleven, Lydie Cherier, Frédérique Teissèdre, Jean-Luc Pouly, Frédéric Dutheil, Anaïs M Duffaud
Author Information
Dahlia Tharwat: Maternité GH Diaconesses Croix St Simon, Paris, France.
Marion Trousselard: Unité de Neurophysiologie du Stress, Département Neurosciences et Contraintes Opérationnelles, Institute de Recherche Biomédicale des Armées, Brétigny Sur Orge, France.
Mélanie Balès: INSERM 1219, EPS Charles Perrens et Centre de RecherchE, Bordeaux, France.
Anne-Laure Sutter-Dallay: INSERM 1219, EPS Charles Perrens et Centre de RecherchE, Bordeaux, France.
Dominique Fromage: Unité de Neurophysiologie du Stress, Département Neurosciences et Contraintes Opérationnelles, Institute de Recherche Biomédicale des Armées, Brétigny Sur Orge, France.
Elisabeth Spitz: Apemac, University of Lorraine, Vandoeuvre-lès-Nancy, France.
Dominique Dallay: Centre Aliénor d'Aquitaine, CHU Pellegrin, University Hospital of Bordeaux, Bordeaux, France.
Thierry Harvey: Maternité GH Diaconesses Croix St Simon, Paris, France.
Eric Welter: CHR Mercy, Regional Hospital of Metz, Metz, France.
Frédéric Coatleven: Centre Aliénor d'Aquitaine, CHU Pellegrin, University Hospital of Bordeaux, Bordeaux, France.
Lydie Cherier: Centre Aliénor d'Aquitaine, CHU Pellegrin, University Hospital of Bordeaux, Bordeaux, France.
Frédérique Teissèdre: Department of In-Vitro Fecondation, Gynecologia, CHU Clermont-Ferrand, University Hospital of Clermont-Ferrand, Clermont-Ferrand, France.
Jean-Luc Pouly: Université Clermont Auvergne, UMR CNRS 6024, LaPSCo, Physiological and Psychosocial Stress, CHU Clermont-Ferrand, University Hospital of Clermont-Ferrand, Occupational and Preventive Medicine, Clermont-Ferrand, France.
Frédéric Dutheil: Faculty of Health, Australian Catholic University, Melbourne, Victoria, Australia.
Anaïs M Duffaud: Unité de Neurophysiologie du Stress, Département Neurosciences et Contraintes Opérationnelles, Institute de Recherche Biomédicale des Armées, Brétigny Sur Orge, France.
INTRODUCTION: The prevalence of postnatal depression (PND) is significant: reaching up to 20% in the general population. In mechanistic terms, the risk of PND lies in an interaction between a maternal psychophysiological vulnerability and a chronic environmental context of stress. On the one hand, repetition of stressor during pregnancy mimics a chronic stress model that is relevant to the study of the allostatic load and the adaptive mechanisms. On the other hand, vulnerability factors reflect a psychological profile mirroring mindfulness functioning (psychological quality that involves bringing one's complete and non-judgemental attention to the present experience on a moment-to-moment basis). This psychological resource is linked to protective and resilient psychic functioning. Thus, PND appears to be a relevant model for studying the mechanisms of chronic stress and vulnerability to psychopathologies.In this article, we present the protocol of an ongoing study (started in May 2017). METHODS AND ANALYSIS: The study is being carried out in five maternities and will involve 260 women. We aim to determine the predictive psychobiological factors for PND emergence and to provide a better insight into the mechanisms involved in chronic stress during pregnancy. We use a multidisciplinary approach that encompasses psychological resources and biophysiological and genetic profiles in order to detect relevant vulnerability biomarkers for chronic stress and the development of PND. To do so, each woman will be involved in the study from her first trimester of pregnancy until 12 months postdelivery. ETHICS AND DISSEMINATION: Ethics approval was obtained from the Ile de France III Ethics Committee, France (2016-A00887-44). We aim to disseminate the findings through international conferences and international peer-reviewed journals. TRIAL REGISTRATION NUMBER: NCT03088319; Pre-results.
