Antimicrobial metabolites from a marine-derived Actinomycete sp. G278.
Duc Tuan Cao, Van Hieu Tran, Van Nam Vu, Huong Doan Thi Mai, Thi Hong Minh Le, Thi Quyen Vu, Hung Huy Nguyen, Van Minh Chau, Van Cuong Pham
Author Information
Duc Tuan Cao: Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) , Hà Nội , Vietnam.
Van Hieu Tran: Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) , Hà Nội , Vietnam.
Van Nam Vu: Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) , Hà Nội , Vietnam.
Huong Doan Thi Mai: Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) , Hà Nội , Vietnam.
Thi Hong Minh Le: Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) , Hà Nội , Vietnam.
Thi Quyen Vu: Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) , Hà Nội , Vietnam.
Hung Huy Nguyen: Faculty of Chemistry, VNU University of Sciences , Hanoi , Vietnam.
Van Minh Chau: Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) , Hà Nội , Vietnam.
Van Cuong Pham: Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) , Hà Nội , Vietnam.
Analysis of an antimicrobial extract prepared from culture broth of the marine-derived actinomycete sp. G278 led to the isolation of ten compounds, -. Two compounds, 2,5-Bis(5--butyl-2-benzoxazolyl)thiophene (), and 3-hydroxyl-2-methylpyridine () were isolated from a natural source for the first time. The structures of the isolated compounds were established by their spectral data analysis, including mass spectrometry, 1D-NMR, 2D-NMR, and X-ray crystallographic analysis in case of compound . All isolated compounds were evaluated for their antimicrobial activity against a panel of clinically significant microorganisms. Compounds and selectively inhibited (MIC: 256 μg/mL). Compound was found to have antibacterial and antifungal activity against (MIC: 64 μg/mL), (MIC: 256 μg/mL), (MIC: 256 μg/mL), (MIC: 256 μg/mL), and (MIC: 64 μg/mL). Except for compounds and , the other known metabolites (-) also exhibited antimicrobial activity.
