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Nutrients
May 31, 2018;10 (6):

Impaired Gastric Myoelectrical Reactivity in Children and Adolescents with Obesity Compared to Normal-Weight Controls.

Katja Weimer, Helene Sauer, Bjoern Horing, Francesco Valitutti, Nazar Mazurak, Stephan Zipfel, Andreas Stengel, Paul Enck, Isabelle Mack
Author Information
  1. Katja Weimer: Clinic for Psychosomatic Medicine and Psychotherapy, University Hospital Ulm, 89081 Ulm, Germany. katja.weimer@uni-ulm.de. ORCID
  2. Helene Sauer: Department of Psychosomatic Medicine and Psychotherapy, University Medical Hospital Tübingen, 72076 Tübingen, Germany. helene.sauer@medizin.uni-tuebingen.de.
  3. Bjoern Horing: Institute of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany. b.horing@uke.de.
  4. Francesco Valitutti: Pediatric Gastroenterology and Liver Unit, Department of Pediatrics, Sapienza University of Rome, 00161 Rome, Italy. francesco.valitutti@uniroma1.it. ORCID
  5. Nazar Mazurak: Department of Psychosomatic Medicine and Psychotherapy, University Medical Hospital Tübingen, 72076 Tübingen, Germany. nazar.mazurak@med.uni-tuebingen.de.
  6. Stephan Zipfel: Department of Psychosomatic Medicine and Psychotherapy, University Medical Hospital Tübingen, 72076 Tübingen, Germany. stephan.zipfel@med.uni-tuebingen.de.
  7. Andreas Stengel: Department of Psychosomatic Medicine and Psychotherapy, University Medical Hospital Tübingen, 72076 Tübingen, Germany. andreas.stengel@med.uni-tuebingen.de.
  8. Paul Enck: Department of Psychosomatic Medicine and Psychotherapy, University Medical Hospital Tübingen, 72076 Tübingen, Germany. paul.enck@uni-tuebingen.de. ORCID
  9. Isabelle Mack: Department of Psychosomatic Medicine and Psychotherapy, University Medical Hospital Tübingen, 72076 Tübingen, Germany. isabelle.mack@uni-tuebingen.de.
PMID: 29857470 DOI: 10.3390/nu10060699

Abstract

Obesity often has its onset in childhood and can be accompanied by various comorbidities such as functional gastrointestinal disorders and altered gastric myoelectrical activity (GMA). This study investigates whether obesity in childhood and adolescence is already associated with altered GMA, and whether an inpatient weight loss program affects GMA. Sixty children with obesity (OBE) and 27 normal-weight children (NW) (12.9 ± 1.7 years; 51% female) were compared for their GMA at rest, after a stress test, and after a drink-to-full water load test. A continuous electrogastrogram (EGG) was recorded and analyzed with respect to gastric slow waves and tachygastric activity. OBE were examined upon admission (T1) and before discharge (T2) following an inpatient weight loss program; NW served as control group. Compared to NW, children with obesity showed flattened GMA as indicated by lower tachygastric reactivity after stress and water load test at T1. Data of OBE did not differ between T1 and T2. EGG parameters were associated neither with sex, age, and BMI nor with subjective stress and food intake. Children with obesity show impaired gastric myoelectrical reactivity in response to a stress and water load test compared to normal-weight controls, which does not change during an inpatient weight loss program.

Keywords

autonomic nervous system brain-gut axis gastric myoelectrical reactivity obesity psychosomatic stress

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MeSH Term

Adolescent
Body Mass Index
Child
Child Nutritional Physiological Phenomena
Comorbidity
Early Diagnosis
Electromyography
Enteric Nervous System
Female
Gastric Mucosa
Gastrointestinal Diseases
Germany
Humans
Male
Overweight
Patient Dropouts
Pediatric Obesity
Prevalence
Stomach
Waist Circumference
Weight Loss
Weight Reduction Programs
Journal Article

Word Cloud

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