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International journal of molecular sciences
05 21, 2018;19 (5):

The CD36-PPARγ Pathway in Metabolic Disorders.

Loïze Maréchal, Maximilien Laviolette, Amélie Rodrigue-Way, Baly Sow, Michèle Brochu, Véronique Caron, André Tremblay
Author Information
  1. Loïze Maréchal: Research Center, CHU Sainte-Justine, Montréal, QC H3T 1C5, Canada. loize.marechal@umontreal.ca.
  2. Maximilien Laviolette: Research Center, CHU Sainte-Justine, Montréal, QC H3T 1C5, Canada. maximilien.laviolette-brassard@umontreal.ca.
  3. Amélie Rodrigue-Way: Research Center, CHU Sainte-Justine, Montréal, QC H3T 1C5, Canada. amelierway@aol.com.
  4. Baly Sow: Research Center, CHU Sainte-Justine, Montréal, QC H3T 1C5, Canada. baly.sow@umontreal.ca.
  5. Michèle Brochu: Department of Physiology, Faculty of Medicine, University of Montreal, Montréal, QC H3T 1J4, Canada. michele.brochu@umontreal.ca.
  6. Véronique Caron: Research Center, CHU Sainte-Justine, Montréal, QC H3T 1C5, Canada. veronique.caron.4@gmail.com.
  7. André Tremblay: Research Center, CHU Sainte-Justine, Montréal, QC H3T 1C5, Canada. andre.tremblay.1@umontreal.ca. ORCID
PMID: 29883404 DOI: 10.3390/ijms19051529

Abstract

Uncovering the biological role of nuclear receptor peroxisome proliferator-activated receptors (PPARs) has greatly advanced our knowledge of the transcriptional control of glucose and energy metabolism. As such, pharmacological activation of PPARγ has emerged as an efficient approach for treating metabolic disorders with the current use of thiazolidinediones to improve insulin resistance in diabetic patients. The recent identification of growth hormone releasing peptides (GHRP) as potent inducers of PPARγ through activation of the scavenger receptor CD36 has defined a novel alternative to regulate essential aspects of lipid and energy metabolism. Recent advances on the emerging role of CD36 and GHRP hexarelin in regulating PPARγ downstream actions with benefits on atherosclerosis, hepatic cholesterol biosynthesis and fat mitochondrial biogenesis are summarized here. The response of PPARγ coactivator PGC-1 is also discussed in these effects. The identification of the GHRP-CD36-PPARγ pathway in controlling various tissue metabolic functions provides an interesting option for metabolic disorders.

Keywords

GHRP PGC-1 PPAR nuclear receptors atherosclerosis energy metabolism fatty acid oxidation hexarelin insulin resistance scavenger receptor

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MeSH Term

Animals
CD36 Antigens
Drug Discovery
Energy Metabolism
Fatty Acids
Humans
Insulin Resistance
Metabolic Diseases
Oligopeptides
PPAR gamma
Signal Transduction

Chemicals

CD36 Antigens
Fatty Acids
Oligopeptides
PPAR gamma
hexarelin
Journal Article Review

Word Cloud

Created with Highcharts 10.0.0PPARγreceptorenergymetabolismmetabolicGHRProlenuclearreceptorsactivationdisordersinsulinresistanceidentificationscavengerCD36hexarelinatherosclerosisPGC-1Uncoveringbiologicalperoxisomeproliferator-activatedPPARsgreatlyadvancedknowledgetranscriptionalcontrolglucosepharmacologicalemergedefficientapproachtreatingcurrentusethiazolidinedionesimprovediabeticpatientsrecentgrowthhormonereleasingpeptidespotentinducersdefinednovelalternativeregulateessentialaspectslipidRecentadvancesemergingregulatingdownstreamactionsbenefitshepaticcholesterolbiosynthesisfatmitochondrialbiogenesissummarizedresponsecoactivatoralsodiscussedeffectsGHRP-CD36-PPARγpathwaycontrollingvarioustissuefunctionsprovidesinterestingoptionCD36-PPARγPathwayMetabolicDisordersPPARfattyacidoxidation

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