Cardiovascular disease is a common disease that threatens the health of human beings,espe-cially elders.The number of people dying from cardiovascular diseases annually ranks top one in the world-wide.Long noncoding RNAs (LncRNAs)is a big group of ncRNAs with nucleotides length >200 nt,and its numbers is most in the body.More and more study found that LcRNAs play critical roles in the pathogenesis and development of cardiovascular disease.This review will describe the latest research progress of long noncoding RNA in cardiovascular diseases.