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Journal of food science and technology
Jun, 2018;55 (6): 2310-2317.

Antioxidant and anti-inflammatory capacities of collagen peptides from milkfish () scales.

Yu-Pei Chen, Chia-Hua Liang, Hong-Tan Wu, Hai-Yue Pang, Chuan Chen, Guey-Horng Wang, Leong-Perng Chan
Author Information
  1. Yu-Pei Chen: Research Center of Natural Cosmeceuticals Engineering, Xiamen Medical College, Xiamen, 361023 Fujian China.
  2. Chia-Hua Liang: 3Department of Cosmetic Science and Institute of Cosmetic Science, Chia Nan University of Pharmacy and Science, Tainan, Taiwan.
  3. Hong-Tan Wu: Research Center of Natural Cosmeceuticals Engineering, Xiamen Medical College, Xiamen, 361023 Fujian China.
  4. Hai-Yue Pang: Research Center of Natural Cosmeceuticals Engineering, Xiamen Medical College, Xiamen, 361023 Fujian China.
  5. Chuan Chen: Department of Pharmacy, Xiamen Medical College, Xiamen, 361023 Fujian China.
  6. Guey-Horng Wang: Research Center of Natural Cosmeceuticals Engineering, Xiamen Medical College, Xiamen, 361023 Fujian China.
  7. Leong-Perng Chan: 5Department of Otolaryngology-Head and Neck Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
PMID: 29892131 DOI: 10.1007/s13197-018-3148-4

Abstract

milkfish (), which is resistant to water quality changes is the fourth largest aquaculture commodity. Abandoned wastes of fish scale and bones aggravate environmental pollution. In this study, the effect of collagen peptides isolated from milkfish scales (MSCP) by pepsin-soluble collagen method on cell viability was investigated. The antioxidant, anti-inflammatory, and DNA-protective activities of MSCP were also evaluated. Results revealed that more than 95% of viable cells were retained in human keratinocytes after addition of 100 mg/mL MSCP. Measurement of DPPH· and ABTS· + radical scavenging activities and cellular reactive oxygen species revealed the high antioxidant activities of MSCP. MSCP demonstrated anti-inflammatory activities by reducing lipoxygenase activity and nitric oxide (NO·) radicals. Moreover, DNA electrophoresis assay indicated that MSCP treatment can directly protect against cyclobutane di-pyrimidine production and DNA single-strand breaks, which are harmful effects of UV radiation and HO. Given its antioxidant, anti-inflammatory, and DNA-protective activities, MSCP has potential applications in cosmeceuticals and supplementary health food.

Keywords

Anti-inflammation Antioxidant Collagen peptide Fish scale Milkfish

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Journal Article

Word Cloud

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