Keisei Kosaki: Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki 305-8577, Japan.
Atsuko Kamijo-Ikemori: Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kanagawa 216-8511, Japan.
Takeshi Sugaya: Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kanagawa 216-8511, Japan.
Koichiro Tanahashi: Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki 305-8577, Japan.
Nobuhiko Akazawa: Faculty of Health and Sport Sciences, University of Tsukuba, Ibaraki 305-8574, Japan.
Chihiro Hibi: Biopharmaceutial Study Group, Pharmaceutical Research Laboratories, Sanwa Kagaku Kenkyusho Company Limited, Mie 511-0406, Japan.
Takashi Nakamura: Biopharmaceutial Study Group, Pharmaceutical Research Laboratories, Sanwa Kagaku Kenkyusho Company Limited, Mie 511-0406, Japan.
Takayo Murase: Radioisotope and Chemical Analysis Center, Sanwa Kagaku Kenkyusho Company Limited, Mie 511-0406, Japan.
Kenjiro Kimura: JCHO Tokyo Takanawa Hospital, Tokyo 108-8606, Japan.
Yugo Shibagaki: Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kanagawa 216-8511, Japan.
Seiji Maeda: Faculty of Health and Sport Sciences, University of Tsukuba, Ibaraki 305-8574, Japan.
The aim of present study was to investigate the association between plasma xanthine oxidoreductase activity, which has gained attention as a novel preventive target of cardiovascular disease, and various physiological parameters and was to determine the effects of habitual exercise on plasma xanthine oxidoreductase activity in middle-aged and older women. In the cross-sectional study, we investigated the association between plasma xanthine oxidoreductase activity and various physiological parameters in 94 middle-aged and older women. In the interventional study, subjects ( = 22) were divided into two groups: exercise ( = 12) or the control group ( = 10), whereby we examined the effect of 12-week aerobic exercise training on plasma xanthine oxidoreductase activity in middle-aged and older women. The cross-sectional study demonstrated that plasma xanthine oxidoreductase activity was significantly associated with various physiological parameters, including visceral fat and daily step counts. In the interventional study, the plasma xanthine oxidoreductase activity significantly decreased after the 12-week aerobic exercise training, its changes were inversely associated with the changes in daily step counts. Our results revealed that the plasma xanthine oxidoreductase activity was associated with visceral fat accumulation and lack of exercise, and it was decreased by the aerobic exercise training.
