Bio-inspired supramolecular materials by orthogonal self-assembly of hydrogelators and phospholipids.
J Boekhoven, A M Brizard, M C A Stuart, L Florusse, G Raffy, A Del Guerzo, J H van Esch
Author Information
J Boekhoven: Department of Chemical Engineering , Delft University of Technology , Julianalaan 136 , 2628BL Delft , The Netherlands . Email: j.h.vanesch@tudelft.nl.
A M Brizard: Department of Chemical Engineering , Delft University of Technology , Julianalaan 136 , 2628BL Delft , The Netherlands . Email: j.h.vanesch@tudelft.nl.
M C A Stuart: Stratingh Institute for Chemistry , University of Groningen , Nijenborgh 7 , 9747AG Groningen , The Netherlands.
L Florusse: Department of Chemical Engineering , Delft University of Technology , Julianalaan 136 , 2628BL Delft , The Netherlands . Email: j.h.vanesch@tudelft.nl.
G Raffy: Univ. Bordeaux , ISM , UMR 5255 , 351 cours de la Lib��ration , 33400 Talence , France.
A Del Guerzo: Univ. Bordeaux , ISM , UMR 5255 , 351 cours de la Lib��ration , 33400 Talence , France.
J H van Esch: Department of Chemical Engineering , Delft University of Technology , Julianalaan 136 , 2628BL Delft , The Netherlands . Email: j.h.vanesch@tudelft.nl. ORCID
The orthogonal self-assembly of multiple components is a powerful strategy towards the formation of complex biomimetic architectures, but so far the rules for designing such systems are unclear. Here we show how to identify orthogonal self-assembly at the supramolecular level and describe guidelines to achieve self-sorting in self-assembled mixed systems. By investigating multicomponent self-assembled systems consisting of low molecular weight gelators and phospholipids, both at a molecular and a supramolecular level, we found that orthogonal self-assembly can only take place if the entities assemble a strong and distinct set of interactions. The resulting supramolecular architectures consist of fibrillar networks that coexist with liposomes and thereby provide additional levels of compartmentalization and enhanced stability as compared to self-assembled systems of gelators or phospholipids alone.
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