OpenLB
Open Library of Bioscience
Advanced Search
Pharmaceutics
Aug 22, 2018;10 (3):

Stimuli Responsive Polymeric Systems for Cancer Therapy.

Ali Alsuraifi, Anthony Curtis, Dimitrios A Lamprou, Clare Hoskins
Author Information
  1. Ali Alsuraifi: Institute of Science and Technology in Medicine, Keele University, Keele ST5 5BG, UK. a.t.y.alsuraifi@keele.ac.uk. ORCID
  2. Anthony Curtis: Institute of Science and Technology in Medicine, Keele University, Keele ST5 5BG, UK. a.d.m.curtis@keele.ac.uk. ORCID
  3. Dimitrios A Lamprou: School of Pharmacy, Queen's University Belfast, Belfast BT9 7BL, UK. d.lamprou@qub.ac.uk. ORCID
  4. Clare Hoskins: Institute of Science and Technology in Medicine, Keele University, Keele ST5 5BG, UK. c.hoskins@keele.ac.uk. ORCID
PMID: 30131473 DOI: 10.3390/pharmaceutics10030136

Abstract

Nanoscale polymers systems have dominated the revolution of drug delivery advancement. Their potential in the fight against cancer is unrivalled with other technologies. Their functionality increase, targeting ability and stimuli responsive nature have led to a major boom in research focus. This review article concentrates on the use of these smart polymers in cancer therapy. Nanotechnologies have shown potential as drug carriers leading to increased drug efficacy and penetration. Multifunctional smart carriers which can release their payload upon an external or internal trigger such as pH or temperature are proving to be major frontrunners in the development of effective strategies to overcome this disease with minimal patient side effects.

Keywords

cancer therapy intelligent polymer smart polymer stimuli responsive

References

  1. Int J Biol Macromol. 2018 Oct 15;118(Pt B):1871-1879 [PMID: 30017982]
  2. Expert Opin Drug Deliv. 2013 Nov;10(11):1497-513 [PMID: 23930949]
  3. Adv Drug Deliv Rev. 2006 Dec 30;58(15):1655-70 [PMID: 17125884]
  4. Bioeng Transl Med. 2016 Oct 17;1(3):297-305 [PMID: 29313018]
  5. J Control Release. 2017 Sep 10;261:43-61 [PMID: 28648865]
  6. Soft Matter. 2015 Jun 28;11(24):4830-9 [PMID: 25986926]
  7. Pharmaceutics. 2017 Sep 25;9(4): [PMID: 28946666]
  8. Biomed Mater. 2009 Apr;4(2):022001 [PMID: 19261988]
  9. J Mater Chem B. 2014 Jul 14;2(26):4142-4152 [PMID: 32261747]
  10. Ther Deliv. 2016;7(1):15-31 [PMID: 26652620]
  11. Adv Drug Deliv Rev. 2010 Feb 17;62(2):231-9 [PMID: 20004693]
  12. Mater Sci Eng C Mater Biol Appl. 2018 Jan 1;82:1-9 [PMID: 29025636]
  13. Soft Matter. 2016 Mar 7;12(9):2542-9 [PMID: 26822456]
  14. J Control Release. 2007 May 14;119(1):111-20 [PMID: 17379347]
  15. Polymers (Basel). 2017 Apr 12;9(4): [PMID: 30970818]
  16. Eur J Pharm Biopharm. 2015 Feb;90:53-62 [PMID: 25448079]
  17. J Am Chem Soc. 2005 Jun 15;127(23):8290-1 [PMID: 15941255]
  18. Int J Pharm. 2014 Oct 1;473(1-2):434-41 [PMID: 25079432]
  19. Pharm Res. 2010 Dec;27(12):2694-703 [PMID: 20872054]
  20. Int J Biol Macromol. 2018 Jul 1;113:737-747 [PMID: 29505869]
  21. Biomaterials. 2015 Dec;71:1-10 [PMID: 26310358]
  22. Biomacromolecules. 2012 Mar 12;13(3):727-35 [PMID: 22288884]
  23. Cancer Res. 2003 Nov 15;63(22):7609-12 [PMID: 14633676]
  24. Biomaterials. 2012 Apr;33(10):2971-9 [PMID: 22244697]
  25. Trends Biotechnol. 2002 Jul;20(7):305-11 [PMID: 12062976]
  26. Pharmacol Ther. 2006 Dec;112(3):630-48 [PMID: 16815554]
  27. Biomaterials. 2014 Jun;35(19):5148-61 [PMID: 24680663]
  28. J Control Release. 2013 Nov 28;172(1):69-76 [PMID: 23954370]
  29. ACS Nano. 2010 Sep 28;4(9):4971-8 [PMID: 20738118]
  30. ACS Macro Lett. 2015 Jun 16;4(6):620-623 [PMID: 35596403]
  31. Nanomedicine (Lond). 2016 Mar;11(6):673-92 [PMID: 27003448]
  32. Polymers (Basel). 2016 Oct 18;8(10): [PMID: 30974643]
  33. Med Hypotheses. 2008 Aug;71(2):249-51 [PMID: 18455320]
  34. J Control Release. 2014 Sep 28;190:371-80 [PMID: 24818766]
  35. Chem Soc Rev. 2013 Sep 7;42(17):7214-43 [PMID: 23450220]
  36. Biomaterials. 2013 May;34(14):3618-25 [PMID: 23419645]
  37. Pharm Res. 2006 Jan;23(1):1-30 [PMID: 16392022]
  38. J Phys Chem B. 2007 Feb 15;111(6):1288-95 [PMID: 17249712]
  39. Eur J Pharm Biopharm. 2015 Oct;96:409-20 [PMID: 26409200]
  40. Expert Opin Drug Deliv. 2007 Sep;4(5):533-46 [PMID: 17880275]
  41. Adv Drug Deliv Rev. 2010 Aug 30;62(11):1064-79 [PMID: 20691229]
  42. Angew Chem Int Ed Engl. 2006 Sep 4;45(35):5792-5 [PMID: 16881026]
  43. Cancer Res. 1994 Nov 1;54(21):5670-4 [PMID: 7923215]
  44. Adv Drug Deliv Rev. 2001 Dec 31;53(3):285-305 [PMID: 11744173]
  45. Mol Pharm. 2006 Mar-Apr;3(2):152-60 [PMID: 16579644]
  46. Int J Pharm. 2013 Nov 1;456(1):202-11 [PMID: 23933441]
  47. Biomaterials. 2013 Sep;34(27):6528-38 [PMID: 23731780]
  48. Adv Drug Deliv Rev. 2010 Feb 17;62(2):203-30 [PMID: 19951732]
  49. J Colloid Interface Sci. 2018 Mar 15;514:468-478 [PMID: 29289031]
  50. Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6803-8 [PMID: 9618493]
  51. Nanotechnology. 2017 Jun 23;28(25):255101 [PMID: 28561013]
  52. Colloids Surf B Biointerfaces. 2008 Dec 1;67(2):245-52 [PMID: 18929467]
  53. Acta Pharm Sin B. 2014 Apr;4(2):120-7 [PMID: 26579373]
  54. Nanotechnology. 2014 Aug 22;25(33):335101 [PMID: 25073730]
  55. Colloids Surf B Biointerfaces. 2008 Jun 15;64(1):34-41 [PMID: 18280118]
  56. Adv Drug Deliv Rev. 2001 Mar 1;46(1-3):125-48 [PMID: 11259837]
  57. Saudi Pharm J. 2016 Sep;24(5):525-536 [PMID: 27752224]
  58. J Control Release. 2012 Jul 20;161(2):152-63 [PMID: 22001607]
  59. Biomaterials. 2012 Feb;33(6):1863-72 [PMID: 22138033]
  60. Pharmaceutics. 2013 May 15;5(2):294-317 [PMID: 24300452]
  61. Chem Mater. 2012 Mar 13;24(5):840-853 [PMID: 22707853]
  62. ACS Nano. 2012 Jan 24;6(1):227-33 [PMID: 22111891]
  63. Nanoscale Res Lett. 2017 Dec;12(1):461 [PMID: 28738665]
  64. Biomacromolecules. 2015 Aug 10;16(8):2493-505 [PMID: 26153904]
Journal Article Review
Article has an altmetric score of 5

Word Cloud

Created with Highcharts 10.0.0drugcancersmartpolymerspotentialstimuliresponsivemajortherapycarrierspolymerNanoscalesystemsdominatedrevolutiondeliveryadvancementfightunrivalledtechnologiesfunctionalityincreasetargetingabilitynatureledboomresearchfocusreviewarticleconcentratesuseNanotechnologiesshownleadingincreasedefficacypenetrationMultifunctionalcanreleasepayloaduponexternalinternaltriggerpHtemperatureprovingfrontrunnersdevelopmenteffectivestrategiesovercomediseaseminimalpatientsideeffectsStimuliResponsivePolymericSystemsCancerTherapyintelligent

Similar Articles

Cited By (20)