Diabetes-Related Cognitive Decline, a Global Health Issue, and New Treatments Approaches.
Vera Novak, Federico Gomez, Alexandre Campos Dias, Daniela A Pimentel, Freddy J Alfaro
Author Information
Vera Novak: Beth Israel Deaconess Medical Center, Boston, MA, USA.
Federico Gomez: Beth Israel Deaconess Medical Center, Boston, MA, USA.
Alexandre Campos Dias: Beth Israel Deaconess Medical Center, Boston, MA, USA.
Daniela A Pimentel: University of Massachusetts Medical School, Worchester, MA, USA.
Freddy J Alfaro: Beth Israel Deaconess Medical Center, Boston, MA, USA.
The epidemic of type 2 diabetes (T2DM ) is spreading around the globe and challenging the unprecedented success of health sciences in increasing longevity. T2DM has been linked to accelerated brain aging, functional decline in older adults and dementia . Brain insulin resistance and glycemic variability are potential mechanisms underlying T2DM -related brain damage and Cognitive Decline T2DM -related cognitive impairment . Wearable technologies now allow better monitoring of behaviors and glycemic levels over several days and deliver real time feedback that can be used to improve self-management and lead to new prevention strategies and therapies for T2DM complications.
Am J Epidemiol. 2008 Nov 15;168(10):1132-9
[PMID: 18836152 ]
Artif Intell Med. 2008 Feb;42(2):153-63
[PMID: 18234481 ]
Neuroendocrinology. 2007;86(2):136-42
[PMID: 17643054 ]
J Telemed Telecare. 2017 Feb;23(2):263-272
[PMID: 26880695 ]
BMC Public Health. 2015 May 27;15:509
[PMID: 26012783 ]
Diabet Med. 2015 May;32(5):609-17
[PMID: 25661981 ]
Neurology. 2004 Oct 12;63(7):1181-6
[PMID: 15477535 ]
Diabetes Care. 2011 Oct;34(10):2152-7
[PMID: 21836103 ]
Hum Brain Mapp. 2014 May;35(5):1944-56
[PMID: 23907764 ]
Drugs. 2012 Jan 1;72(1):49-66
[PMID: 22191795 ]
N Engl J Med. 2007 Jul 26;357(4):370-9
[PMID: 17652652 ]
Diabetes. 2014 Nov;63(11):3596-605
[PMID: 24947353 ]
Int J Clin Exp Pathol. 2014 Dec 01;7(12):8848-54
[PMID: 25674254 ]
Circ J. 2011;75(5):1042-8
[PMID: 21441696 ]
Diabetes Metab Res Rev. 2006 Nov-Dec;22(6):423-36
[PMID: 16506274 ]
Diabetes Care. 2014;37(3):751-9
[PMID: 24101698 ]
BMC Womens Health. 2015 Mar 27;15:30
[PMID: 25886945 ]
N Engl J Med. 2008 Jun 12;358(24):2630-3
[PMID: 18539918 ]
J Clin Endocrinol Metab. 2012 Feb;97(2):366-76
[PMID: 22162476 ]
Nat Neurosci. 2002 Jun;5(6):514-6
[PMID: 11992114 ]
Neurology. 2015 Aug 4;85(5):450-8
[PMID: 26156513 ]
J Clin Invest. 2006 Jul;116(7):1761-6
[PMID: 16823473 ]
Diabetologia. 2010 Jan;53(1):58-65
[PMID: 19882137 ]
Diabetes Care. 2009 Feb;32(2):221-6
[PMID: 19171735 ]
Diabetologia. 2008 Jul;51(7):1321-6
[PMID: 18488188 ]
CNS Drugs. 2013 Jul;27(7):505-14
[PMID: 23719722 ]
Dement Geriatr Cogn Disord. 2010;30(5):381-6
[PMID: 20962529 ]
Stud Health Technol Inform. 2004;108:49-55
[PMID: 15718629 ]
Neurology. 2008 Feb 5;70(6):440-8
[PMID: 17942819 ]
Diabetes. 2015 Mar;64(3):1025-34
[PMID: 25249577 ]
Arch Neurol. 2012 Jan;69(1):29-38
[PMID: 21911655 ]
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