Phytochemical Molluscicides and Schistosomiasis: What We Know and What We Still Need to Learn.

Ronaldo de Carvalho Augusto, Clélia Christina Mello Silva
Author Information
  1. Ronaldo de Carvalho Augusto: Laboratory of Ecology and Evolution of Interactions 2EI, University Perpignan Via Domitia, IHPE UMR 5244, CNRS, IFREMER, Univ. Montpellier, 66860 Perpignan, France. ronaldo.augusto@univ-perp.fr. ORCID
  2. Clélia Christina Mello Silva: Laboratório de Avaliação e Promoção e Saúde Ambiental, Oswaldo Cruz Institute, Rio de Janeiro 21040-360, Brazil. clelia@ioc.fiocruz.br.

Abstract

Worldwide schistosomiasis remains a serious public health problem with approximately 67 million people infected and 200 million at risk of infection from inhabiting or transiting endemically active regions. Africa, South America, the Caribbean, and the Middle East are the main transmission regions of . The fight against transmission through the use of molluscicides is not recent and has been advocated as the only activity with the possibility of interruption of transmission in small, epidemiologically active outbreaks. var. (syn. ) (Des Moulins, 1826) is the most promising for use in official schistosomiasis control programs according to the WHO. In this review, we show that an understanding of some how latex affects the snail vector and their parasites from a molecular level to field conditions is lacking. On the other hand, this type of treatment could also provide a rationale for the control of schistosomiasis and other parasitosis. Several publications contribute to enforcing the use of latex in endemic countries as a cheap alternative or complement to mass drug treatment with praziquantel, the only available drug to cure the patients (without preventing re-infection).

Keywords

References

  1. BMJ. 1999 Nov 27;319(7222):1423-5 [PMID: 10574867]
  2. J Toxicol Clin Toxicol. 2000;38(1):67-9 [PMID: 10696929]
  3. Ecotoxicol Environ Saf. 2000 Jul;46(3):342-50 [PMID: 10903832]
  4. Mem Inst Oswaldo Cruz. 2001 Jan;96(1):123-5 [PMID: 11285483]
  5. Cell Mol Life Sci. 2001 Apr;58(4):556-70 [PMID: 11361091]
  6. Acta Trop. 2001 May 25;79(2):165-70 [PMID: 11369309]
  7. Trop Med Int Health. 2001 Nov;6(11):864-73 [PMID: 11703840]
  8. Mem Inst Oswaldo Cruz. 2003 Jun;98(4):557-63 [PMID: 12937774]
  9. Toxicol Lett. 2003 Nov 30;145(2):175-80 [PMID: 14581170]
  10. Trends Parasitol. 2005 Mar;21(3):112-7 [PMID: 15734657]
  11. Mem Inst Oswaldo Cruz. 2006 Feb;101(1):3-8 [PMID: 16612505]
  12. Regul Toxicol Pharmacol. 1991 Oct;14(2):189-201 [PMID: 1792353]
  13. J Clin Invest. 2008 Apr;118(4):1311-21 [PMID: 18382743]
  14. Mem Inst Oswaldo Cruz. 1991;86 Suppl 2:87-8 [PMID: 1842019]
  15. Chem Rev. 2008 Oct;108(10):4295-327 [PMID: 18817355]
  16. Russ J Plant Physiol. 2008 Jul;55(4):564-567 [PMID: 19578478]
  17. J Appl Toxicol. 2010 Jan;30(1):1-7 [PMID: 19943357]
  18. Phytochemistry. 2010 May;71(7):708-15 [PMID: 20206951]
  19. Vet Parasitol. 2010 Aug 27;172(1-2):100-4 [PMID: 20627417]
  20. Mem Inst Oswaldo Cruz. 2010 Jul;105(4):492-5 [PMID: 20721497]
  21. Acta Trop. 2011 Feb;117(2):101-4 [PMID: 21055383]
  22. Health Res Policy Syst. 2011 Jan 06;9:3 [PMID: 21211001]
  23. Mem Inst Oswaldo Cruz. 2011 Mar;106(2):153-7 [PMID: 21537673]
  24. J Ethnopharmacol. 1990 Jul;29(3):291-4 [PMID: 2214815]
  25. Mini Rev Med Chem. 2013 Apr;13(4):493-508 [PMID: 23373654]
  26. Parasitology. 2013 Oct;140(12):1534-46 [PMID: 23552512]
  27. Philos Trans R Soc Lond B Biol Sci. 2013 Jun 24;368(1623):20120144 [PMID: 23798692]
  28. Parasitology. 2015 Feb;142(2):332-40 [PMID: 25003984]
  29. J Adv Res. 2013 Sep;4(5):425-32 [PMID: 25685449]
  30. PLoS Negl Trop Dis. 2015 Aug 25;9(8):e0003853 [PMID: 26305466]
  31. PLoS Negl Trop Dis. 2015 Dec 28;9(12):e0004290 [PMID: 26709922]
  32. Mem Inst Oswaldo Cruz. 1989 Oct;84 Suppl 1:76-83 [PMID: 2700594]
  33. PLoS Negl Trop Dis. 2017 Jul 28;11(7):e0005789 [PMID: 28753630]
  34. PLoS Negl Trop Dis. 2017 Oct 26;11(10):e0005812 [PMID: 29073138]
  35. Mem Inst Oswaldo Cruz. 1986 Oct-Dec;81(4):475-6 [PMID: 3613981]
  36. Bull World Health Organ. 1973;48(3):299-307 [PMID: 4542798]
  37. Bull World Health Organ. 1970;42(4):597-612 [PMID: 5310955]
  38. Trans R Soc Trop Med Hyg. 1979;73(4):375-80 [PMID: 555062]
  39. J Nat Prod. 1984 Jul-Aug;47(4):702-5 [PMID: 6491683]
  40. Planta Med. 1983 Mar;47(3):141-7 [PMID: 6856693]
  41. Phytochemistry. 1994 Jan;35(1):95-9 [PMID: 7764378]
  42. J Egypt Soc Parasitol. 1994 Apr;24(1):231-8 [PMID: 8169447]
  43. Mutat Res. 1996 May;368(1):15-20 [PMID: 8637506]
  44. Braz J Med Biol Res. 1997 Nov;30(11):1325-32 [PMID: 9532242]
  45. Mem Inst Oswaldo Cruz. 1997 Sep-Oct;92(5):719-24 [PMID: 9566245]
  46. Mem Inst Oswaldo Cruz. 1998;93 Suppl 1:235-7 [PMID: 9921358]

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