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Antibiotics (Basel, Switzerland)
Nov 06, 2018;7 (4):

First Description of Colistin and Tigecycline-Resistant Producing KPC-3 Carbapenemase in Portugal.

Cátia Caneiras, Filipa Calisto, Gabriela Jorge da Silva, Luis Lito, José Melo-Cristino, Aida Duarte
Author Information
  1. Cátia Caneiras: Microbiology and Immunology Department, Interdisciplinary Research Centre Egas Moniz (CiiEM), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisboa, Portugal. ccaneiras@gmail.com. ORCID
  2. Filipa Calisto: Microbiology and Immunology Department, Interdisciplinary Research Centre Egas Moniz (CiiEM), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisboa, Portugal. fcalisto@itqb.unl.pt. ORCID
  3. Gabriela Jorge da Silva: Faculty of Pharmacy, Universidade de Coimbra, Polo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal. gjsilva@ci.uc.pt.
  4. Luis Lito: Laboratory of Microbiology, Centro Hospitalar Lisboa Norte, 1649-035 Lisboa, Portugal. lmlito@chln.min-saude.pt.
  5. José Melo-Cristino: Laboratory of Microbiology, Centro Hospitalar Lisboa Norte, 1649-035 Lisboa, Portugal. melo_cristino@medicina.ulisboa.pt.
  6. Aida Duarte: Microbiology and Immunology Department, Interdisciplinary Research Centre Egas Moniz (CiiEM), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisboa, Portugal. aduarte@ff.ulisboa.pt. ORCID
PMID: 30404152 DOI: 10.3390/antibiotics7040096

Abstract

Herein, we describe a case report of carbapenem-resistant and isolates that were identified from the same patient at a Tertiary University Hospital Centre in Portugal. Antimicrobial susceptibility and the molecular characterization of resistance and virulence determinants were performed. PCR screening identified the presence of the resistance genes , and in both isolates. The KPC-3 isolate belonged to the ST-14 high risk clone and accumulated an uncommon resistance and virulence profile additional to a horizontal dissemination capacity. In conclusion, the molecular screening led to the first identification of the KPC-3 producer in Portugal with a full antimicrobial resistance profile including tigecycline and colistin.

Keywords

A. baumannii Gram-negative bacteria K. pneumoniae KPC-3 carbapenemase antimicrobial resistance colistin tigecycline

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Case Reports Journal Article
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