The Antitumor Activities of .

Xiang Wang, Yuanliang Yan, Xi Chen, Shuangshuang Zeng, Long Qian, Xinxin Ren, Jie Wei, Xue Yang, Yangying Zhou, Zhicheng Gong, Zhijie Xu
Author Information
  1. Xiang Wang: Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China.
  2. Yuanliang Yan: Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China.
  3. Xi Chen: Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China.
  4. Shuangshuang Zeng: Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China.
  5. Long Qian: Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China.
  6. Xinxin Ren: Key Laboratory of Molecular Radiation Oncology of Hunan Province, Center for Molecular Medicine, Xiangya Hospital, Central South University, Changsha, China.
  7. Jie Wei: Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China.
  8. Xue Yang: Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China.
  9. Yangying Zhou: Department of Oncology, Xiangya Hospital, Central South University, Changsha, China.
  10. Zhicheng Gong: Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China.
  11. Zhijie Xu: Department of Pathology, Xiangya Hospital, Central South University, Changsha, China.

Abstract

(MT), a traditional Chinese herbal medicine, has long been used for thousands of years to treat asthma, tracheitis, rheumatism, etc. An increasing number of recent studies have focused on the antitumor effects of MT. The effects of MT on cancer are the result of various activated signaling pathways and inhibiting factors and the high expression levels of regulatory proteins. MT can inhibit different cancer types including non-small cell lung cancer (NSCLC), malignant tumors, hepatic carcinoma, and so on. This article mainly focuses on the activities and mechanisms of MT. In addition, the efficacy and toxicity of MT are also discussed. Further studies of MT are required for improved medicinal utilization.

Keywords

References

  1. J Pharm Biomed Anal. 2017 Oct 25;145:127-136 [PMID: 28662480]
  2. Oncol Lett. 2017 May;13(5):2897-2902 [PMID: 28521395]
  3. Biosci Trends. 2018;12(3):220-239 [PMID: 30012913]
  4. Sci Rep. 2018 Jan 22;8(1):1323 [PMID: 29358632]
  5. J Ethnopharmacol. 2014 Apr 11;153(1):258-67 [PMID: 24583069]
  6. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jul 15;1026:204-216 [PMID: 26657802]
  7. Chin J Nat Med. 2016 Dec;14(12):922-930 [PMID: 28262119]
  8. Planta Med. 2017 Jan;83(1-02):126-134 [PMID: 27272399]
  9. PLoS One. 2017 Apr 17;12(4):e0175977 [PMID: 28414793]
  10. Forsch Komplementmed. 2015;22(3):172-9 [PMID: 26088552]
  11. Med Sci Monit. 2018 Sep 09;24:6289-6297 [PMID: 30196309]
  12. Brief Bioinform. 2016 Mar;17(2):309-21 [PMID: 26153512]
  13. Leuk Lymphoma. 2016 Feb;57(2):419-428 [PMID: 25942381]
  14. Sci Rep. 2017 Jun 20;7(1):3917 [PMID: 28634395]
  15. Clin Lab. 2015;61(10):1553-60 [PMID: 26642719]
  16. Cancer Chemother Pharmacol. 2017 Feb;79(2):227-231 [PMID: 27515517]
  17. Oncol Lett. 2013 Mar;5(3):917-922 [PMID: 23426522]
  18. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Jul 1;877(20-21):1799-804 [PMID: 19481986]
  19. Steroids. 2010 Feb;75(2):176-83 [PMID: 19925814]
  20. Lung Cancer. 2012 Jan;75(1):30-7 [PMID: 21757251]
  21. J Nat Prod. 2008 Jun;71(6):1049-51 [PMID: 18512984]
  22. J Pharmacopuncture. 2014 Jun;17(2):7-17 [PMID: 25780694]
  23. Genes (Basel). 2018 Jan 04;9(1):null [PMID: 29300342]
  24. J Asian Nat Prod Res. 2010 Aug;12(8):654-61 [PMID: 20706900]
  25. Steroids. 2015 Jan;93:68-76 [PMID: 25447796]
  26. Cancer Res. 2015 Nov 15;75(22):4985-97 [PMID: 26420216]
  27. J Drug Target. 2018 Sep 17;:1-49 [PMID: 30221549]
  28. BMC Complement Altern Med. 2014 May 22;14:165 [PMID: 24884778]
  29. Chin J Nat Med. 2015 Jun;13(6):428-37 [PMID: 26073339]
  30. Sci Pharm. 2017 Aug 21;85(3): [PMID: 28825665]
  31. J Ethnopharmacol. 2014;151(1):210-7 [PMID: 24157377]
  32. J Asian Nat Prod Res. 2011 Jun;13(6):477-85 [PMID: 21623509]
  33. PLoS One. 2018 Apr 6;13(4):e0195240 [PMID: 29624609]
  34. Steroids. 2018 Aug;136:76-92 [PMID: 29360535]
  35. J Tradit Chin Med. 2016 Jun;36(3):261-70 [PMID: 27468539]
  36. J Clin Oncol. 2016 May 1;34(13):1431-2 [PMID: 26884571]
  37. Environ Toxicol Pharmacol. 2014 Jan;37(1):300-14 [PMID: 24384279]
  38. Genet Mol Res. 2014 Jan 21;13(1):354-62 [PMID: 24535862]
  39. J Zhejiang Univ Sci B. 2017 Jul;18(7):597-604 [PMID: 28681584]
  40. Eur J Cancer. 2018 Nov;103:356-387 [PMID: 30100160]
  41. Nat Mater. 2018 Aug;17(8):732-739 [PMID: 29867165]
  42. CA Cancer J Clin. 2015 Mar;65(2):87-108 [PMID: 25651787]
  43. J Cell Mol Med. 2018 May;22(5):2692-2705 [PMID: 29512890]
  44. Oncotarget. 2017 May 24;8(34):56893-56905 [PMID: 28915640]
  45. Biomed Chromatogr. 2016 Nov;30(11):1757-1765 [PMID: 27106066]
  46. Biomed Chromatogr. 2015 Apr;29(4):633-40 [PMID: 25223404]
  47. Oncotarget. 2015 Mar 20;6(8):5804-17 [PMID: 25714020]
  48. J Mass Spectrom. 2012 Jun;47(6):687-93 [PMID: 22678950]
  49. Phytochemistry. 2016 Jun;126:47-58 [PMID: 26988729]
  50. JACC Cardiovasc Imaging. 2018 Aug;11(8):1084-1093 [PMID: 30092967]
  51. J Tradit Chin Med. 2013 Feb;33(1):34-8 [PMID: 23596809]
  52. Theor Biol Med Model. 2015 Jul 02;12:13 [PMID: 26133367]
  53. Nature. 2017 Oct 5;550(7674):133-136 [PMID: 28953887]
  54. Oncotarget. 2016 Dec 13;7(50):82851-82863 [PMID: 27756877]
  55. Trends Plant Sci. 2015 Jan;20(1):56-64 [PMID: 25457109]
  56. Nat Rev Clin Oncol. 2015 Aug;12(8):436 [PMID: 26099984]
  57. J Ethnopharmacol. 2017 May 5;203:110-119 [PMID: 28363522]
  58. J Exp Clin Cancer Res. 2016 Feb 02;35:23 [PMID: 26830677]
  59. J Nat Med. 2018 Jan;72(1):166-180 [PMID: 28914410]
  60. Nat Rev Cancer. 2016 Mar;16(3):163-72 [PMID: 26911190]
  61. Nat Commun. 2017 Sep 7;8(1):480 [PMID: 28883393]
  62. Genomics. 2014 Sep;104(3):186-93 [PMID: 25128726]
  63. Chin J Nat Med. 2016 Mar;14(3):203-9 [PMID: 27025367]
  64. Molecules. 2014 Sep 05;19(9):13965-75 [PMID: 25197933]
  65. Nat Rev Immunol. 2013 Sep;13(9):679-92 [PMID: 23954936]
  66. Oncotarget. 2017 Nov 30;8(66):110576-110591 [PMID: 29299170]
  67. Front Pharmacol. 2016 Dec 02;7:473 [PMID: 27994551]
  68. J Pharm Biomed Anal. 2018 Jan 30;148:80-88 [PMID: 28965048]
  69. Planta Med. 2014 Jan;80(1):29-38 [PMID: 24338554]
  70. Carbohydr Polym. 2016 Feb 10;137:52-58 [PMID: 26686104]
  71. Pharmacogn Mag. 2015 May;11(Suppl 1):S73-85 [PMID: 26109778]
  72. Int J Hematol. 2018 Apr;107(4):405-412 [PMID: 29388166]
  73. Phytomedicine. 2015 May 15;22(5):560-7 [PMID: 25981922]
  74. Nat Prod Commun. 2014 Feb;9(2):155-6 [PMID: 24689277]
  75. Cell. 2005 Aug 12;122(3):421-34 [PMID: 16096061]
  76. J Nat Prod. 2014 Sep 26;77(9):2044-53 [PMID: 25215856]

Word Cloud

Created with Highcharts 10.0.0MTcancerstudiesantitumoreffectssignalingpathwaysmalignantactivitiesefficacytoxicitytraditionalChineseherbalmedicinelongusedthousandsyearstreatasthmatracheitisrheumatismetcincreasingnumberrecentfocusedresultvariousactivatedinhibitingfactorshighexpressionlevelsregulatoryproteinscaninhibitdifferenttypesincludingnon-smallcelllungNSCLCtumorshepaticcarcinomaarticlemainlyfocusesmechanismsadditionalsodiscussedrequiredimprovedmedicinalutilizationAntitumorActivitiesMarsdeniatenacissimatumor

Similar Articles

Cited By