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The Biochemical journal
11 20, 2018;475 (22): 3511-3534.

Chemical biology probes of mammalian GLUT structure and function.

Geoffrey D Holman
Author Information
  1. Geoffrey D Holman: Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, U.K. g.d.holman@bath.ac.uk. ORCID
PMID: 30459202 DOI: 10.1042/BCJ20170677

Abstract

The structure and function of glucose transporters of the mammalian GLUT family of proteins has been studied over many decades, and the proteins have fascinated numerous research groups over this time. This interest is related to the importance of the GLUTs as archetypical membrane transport facilitators, as key limiters of the supply of glucose to cell metabolism, as targets of cell insulin and exercise signalling and of regulated membrane traffic, and as potential drug targets to combat cancer and metabolic diseases such as type 2 diabetes and obesity. This review focusses on the use of chemical biology approaches and sugar analogue probes to study these important proteins.

Keywords

GLUT proteins GLUT4 translocation insulin action

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Grants

  1. G9225018/Medical Research Council
  2. MR/J003417/1/Medical Research Council

MeSH Term

Animals
Diabetes Mellitus, Type 2
Glucose
Glucose Transport Proteins, Facilitative
Humans
Mammals
Models, Molecular
Obesity
Protein Binding
Protein Domains

Chemicals

Glucose Transport Proteins, Facilitative
Glucose
Journal Article Research Support, Non-U.S. Gov't Review
Article has an altmetric score of 9

Word Cloud

Created with Highcharts 10.0.0proteinsGLUTstructurefunctionglucosemammalianmembranecelltargetsinsulinbiologyprobestransportersfamilystudiedmanydecadesfascinatednumerousresearchgroupstimeinterestrelatedimportanceGLUTsarchetypicaltransportfacilitatorskeylimiterssupplymetabolismexercisesignallingregulatedtrafficpotentialdrugcombatcancermetabolicdiseasestype2diabetesobesityreviewfocussesusechemicalapproachessugaranaloguestudyimportantChemicalGLUT4translocationaction

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