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Journal of hepatology
03, 2019;70 (3): 501-520.

Evolutionary biology of human hepatitis viruses.

Andrea Rasche, Anna-Lena Sander, Victor Max Corman, Jan Felix Drexler
Author Information
  1. Andrea Rasche: Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Virology, 10117 Berlin, Germany; German Center for Infection Research (DZIF), Germany.
  2. Anna-Lena Sander: Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Virology, 10117 Berlin, Germany.
  3. Victor Max Corman: Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Virology, 10117 Berlin, Germany; German Center for Infection Research (DZIF), Germany.
  4. Jan Felix Drexler: Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Virology, 10117 Berlin, Germany; German Center for Infection Research (DZIF), Germany. Electronic address: felix.drexler@charite.de.
PMID: 30472320 DOI: 10.1016/j.jhep.2018.11.010

Abstract

Hepatitis viruses are major threats to human health. During the last decade, highly diverse viruses related to human hepatitis viruses were found in animals other than primates. Herein, we describe both surprising conservation and striking differences of the unique biological properties and infection patterns of human hepatitis viruses and their animal homologues, including transmission routes, liver tropism, oncogenesis, chronicity, pathogenesis and envelopment. We discuss the potential for translation of newly discovered hepatitis viruses into preclinical animal models for drug testing, studies on pathogenesis and vaccine development. Finally, we re-evaluate the evolutionary origins of human hepatitis viruses and discuss the past and present zoonotic potential of their animal homologues.

Keywords

Evolution Hepatitis Homologues Virus Zoonotic

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MeSH Term

Animals
Antiviral Agents
Biological Evolution
Drug Development
Hepatitis Viruses
Hepatitis, Animal
Hepatitis, Viral, Human
Humans
Models, Animal
Viral Hepatitis Vaccines

Chemicals

Antiviral Agents
Viral Hepatitis Vaccines
Journal Article Research Support, Non-U.S. Gov't Review
Article has an altmetric score of 36

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