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2018;7

Recent advances in imaging and understanding interstitial cystitis.

Pradeep Tyagi, Chan-Hong Moon, Joseph Janicki, Jonathan Kaufman, Michael Chancellor, Naoki Yoshimura, Christopher Chermansky
Author Information
  1. Pradeep Tyagi: Urology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, 15213, USA.
  2. Chan-Hong Moon: Radiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, 15213, USA.
  3. Joseph Janicki: Lipella, Pittsburgh, USA.
  4. Jonathan Kaufman: Lipella, Pittsburgh, USA.
  5. Michael Chancellor: Urology, OU- Beaumont school of medicine, Royal oak, USA.
  6. Naoki Yoshimura: Urology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, 15213, USA.
  7. Christopher Chermansky: Urology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, 15213, USA.
PMID: 30473772 DOI: 10.12688/f1000research.16096.1

Abstract

Interstitial cystitis/bladder pain syndrome (IC/BPS) is a debilitating condition associated with intense pelvic pain and bladder storage symptoms. Since diagnosis is difficult, prevalence estimates vary with the methodology used. There is also a lack of proven imaging tools and biomarkers to assist in differentiation of IC/BPS from other urinary disorders (overactive bladder, vulvodynia, endometriosis, and prostatitis). Current uncertainty regarding the etiology and pathology of IC/BPS ultimately impacts its timely and successful treatment, as well as hampers future drug development. This review will cover recent developments in imaging methods, such as magnetic resonance imaging, that advance the understanding of IC/BPS and guide drug development.

Keywords

Interstitial cystitis MRI bladder wall fibrosis imaging radiation

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Grants

  1. R42 DK108397/NIDDK NIH HHS
  2. R41 DK108397/NIDDK NIH HHS

MeSH Term

Animals
Biomarkers
Cystitis, Interstitial
Diagnosis, Differential
Fibrosis
Humans
Magnetic Resonance Imaging

Chemicals

Biomarkers
Journal Article Research Support, N.I.H., Extramural Review

Word Cloud

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