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Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
Nov, 2018;20 (11): 958-963.

[Advances in the treatment of juvenile myelomonocytic leukemia].

Yu-Li Cai, Jing-Liao Zhang, Xiao-Fan Zhu
Author Information
  1. Yu-Li Cai: Department of Pediatrics, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, Tianjin 300020, China. lily4e09@163.com.
PMID: 30477631

Abstract

Juvenile myelomonocytic leukemia (JMML) is a rare chronic myeloid leukemia in children and has the features of both myelodysplastic syndrome and myeloproliferative neoplasm. It is highly malignant and has a poor treatment outcome. Children with JMML have a poor response to conventional chemotherapy. At present, hematopoietic stem cell transplantation is the only possible cure for this disease. In recent years, significant progress has been made in targeted therapy for mutant genes in the Ras signaling pathway and demethylation treatment of aberrant methylation of polygenic CpG islands. This article reviews the treatment and efficacy evaluation of JMML.

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MeSH Term

Child
Hematopoietic Stem Cell Transplantation
Humans
Leukemia, Myelomonocytic, Juvenile
Methylation
Myelodysplastic Syndromes
Signal Transduction
Journal Article Review

Word Cloud

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