Lack of T-cell-mediated IL-2 and TNFα production is linked to decreased CD58 expression in intestinal tissue during acute simian immunodeficiency virus infection.
Diganta Pan, Arpita Das, Sudesh K Srivastav, Vicki Traina-Dorge, Peter J Didier, Bapi Pahar
Author Information
Diganta Pan: 1Division of Comparative Pathology, Covington, Louisiana.
Arpita Das: 2Division of Microbiology, Tulane National Primate Research Center, Covington, Louisiana, USA.
Sudesh K Srivastav: 3Department of Biostatistics and Bioinformatics, Tulane University, New Orleans, Louisiana, USA.
Vicki Traina-Dorge: 2Division of Microbiology, Tulane National Primate Research Center, Covington, Louisiana, USA.
Peter J Didier: 1Division of Comparative Pathology, Covington, Louisiana.
Bapi Pahar: 1Division of Comparative Pathology, Covington, Louisiana.
For an effective T-cell activation and response, co-stimulation is required in addition to the antigen-specific signal from their antigen receptors. The CD2/CD58 interaction is considered as one of the most important T-cell co-stimulatory pathways for T-cell activation and proliferation, and its role in regulating intestinal T-cell function in acute and chronic SIV -infected macaques is poorly documented. Here, we demonstrated a significant reduction of CD58 expression in both T- and B-cell populations during acute SIV infection along with high plasma viral load and a loss of intestinal CD4 T cells compared to SIV-uninfected control macaques. The reduction of CD58 expression in T cells was correlated with the reduced expression of T-cell-mediated IL-2 and TNFα production. Together, these results indicate that reduction in the CD2/CD58 interaction pathway in mucosal lymphocytes might play a crucial role in mucosal T-cell dysfunction during acute SIV/HIV infection.
