OpenLB
Open Library of Bioscience
Advanced Search
Quantitative imaging in medicine and surgery
Oct, 2018;8 (9): 957-970.

Design and synthesis of magnetic nanoparticles for biomedical diagnostics.

Yuan Chen, Xianguang Ding, Yan Zhang, Auginia Natalia, Xuecheng Sun, Zhigang Wang, Huilin Shao
Author Information
  1. Yuan Chen: Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore 117599, Singapore.
  2. Xianguang Ding: Biomedical Institute for Global Health Research and Technology, National University of Singapore, Singapore 117599, Singapore.
  3. Yan Zhang: Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore 117599, Singapore.
  4. Auginia Natalia: Biomedical Institute for Global Health Research and Technology, National University of Singapore, Singapore 117599, Singapore.
  5. Xuecheng Sun: Biomedical Institute for Global Health Research and Technology, National University of Singapore, Singapore 117599, Singapore.
  6. Zhigang Wang: Biomedical Institute for Global Health Research and Technology, National University of Singapore, Singapore 117599, Singapore.
  7. Huilin Shao: Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore 117599, Singapore.
PMID: 30505724 DOI: 10.21037/qims.2018.10.07

Abstract

Sensitive and quantitative characterization of clinically relevant biomarkers can facilitate disease diagnosis and treatment evaluation. Magnetic nanomaterials and their biosensing strategies have recently received considerable attention. Magnetic signals experience little interference from native biological background as most biological molecules have negligible magnetic susceptibilities and thus appear transparent to external magnetic fields. Because of this unique property, magnetic sensing can be applied to both deep tissue imaging as well as point-of-care diagnostics. To exploit this mode of magnetic detection, new advancements in both magnetic material syntheses and sensing technologies have been made. This review focuses on recent developments of magnetic nanomaterials as image contrast agents and diagnostic sensors. These developments have not only enabled precise control of magnetic nanomaterial properties but also expanded the reach of magnetic detection for biomedical diagnostics.

Keywords

Magnetic nanoparticles (NPs) ex vivo detection in vivo imaging miniaturized sensors

References

  1. Nat Med. 2009 Nov;15(11):1327-32 [PMID: 19820717]
  2. Science. 2003 Oct 31;302(5646):830-4 [PMID: 14593169]
  3. J Am Chem Soc. 2004 Sep 22;126(37):11458-9 [PMID: 15366890]
  4. J Colloid Interface Sci. 2005 Nov 1;291(1):144-51 [PMID: 15963522]
  5. Angew Chem Int Ed Engl. 2007;46(28):5397-401 [PMID: 17357103]
  6. Nanoscale. 2015 Oct 21;7(39):16165-9 [PMID: 26377439]
  7. J Am Chem Soc. 2007 Feb 7;129(5):1428-33 [PMID: 17263428]
  8. Adv Mater. 2012 Dec 4;24(46):6223-8 [PMID: 22972529]
  9. Chem Rev. 2018 Feb 28;118(4):1917-1950 [PMID: 29384376]
  10. Adv Mater. 2017 Jun;29(24): [PMID: 28402594]
  11. Biosens Bioelectron. 2004 May 15;19(10):1149-56 [PMID: 15046745]
  12. Nanoscale. 2015 Aug 7;7(29):12728-36 [PMID: 26154916]
  13. Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12459-64 [PMID: 19620715]
  14. Nat Mater. 2008 Sep;7(9):691-2 [PMID: 18719701]
  15. Adv Mater. 2014 May;26(17):2694-8, 2016 [PMID: 24615901]
  16. J Am Chem Soc. 2011 Aug 17;133(32):12624-31 [PMID: 21744804]
  17. ACS Nano. 2017 May 23;11(5):4582-4592 [PMID: 28426929]
  18. Chem Rev. 2016 Sep 28;116(18):10473-512 [PMID: 27355413]
  19. Nat Rev Cancer. 2003 Apr;3(4):267-75 [PMID: 12671665]
  20. Angew Chem Int Ed Engl. 2005 Apr 29;44(18):2782-5 [PMID: 15798982]
  21. Adv Mater. 2010 Jul 6;22(25):2729-42 [PMID: 20473985]
  22. Science. 2000 Sep 1;289(5484):1530-1532 [PMID: 10968784]
  23. Quant Imaging Med Surg. 2017 Feb;7(1):88-122 [PMID: 28275562]
  24. Biosens Bioelectron. 2005 Feb 15;20(8):1611-6 [PMID: 15626616]
  25. Nat Rev Cancer. 2005 Nov;5(11):845-56 [PMID: 16239904]
  26. Biosens Bioelectron. 2007 Apr 15;22(9-10):2366-70 [PMID: 17084072]
  27. Chem Commun (Camb). 2014 Jan 7;50(2):174-6 [PMID: 24225594]
  28. Angew Chem Int Ed Engl. 2011 Nov 4;50(45):10589-93 [PMID: 21928456]
  29. ACS Nano. 2012 Aug 28;6(8):6821-8 [PMID: 22762250]
  30. Science. 2004 Feb 6;303(5659):821-3 [PMID: 14764874]
  31. Acc Chem Res. 2011 Oct 18;44(10):863-74 [PMID: 21823593]
  32. Eur Radiol. 2001;11(11):2319-31 [PMID: 11702180]
  33. Sci Transl Med. 2012 Jul 4;4(141):141ra92 [PMID: 22764208]
  34. ACS Nano. 2011 May 24;5(5):3438-46 [PMID: 21495676]
  35. Chem Rev. 2015 Oct 14;115(19):10690-724 [PMID: 26258867]
  36. Beilstein J Nanotechnol. 2010;1:142-54 [PMID: 21977404]
  37. Nano Lett. 2005 Feb;5(2):379-82 [PMID: 15794629]
  38. J Am Chem Soc. 2004 Nov 10;126(44):14583-99 [PMID: 15521779]
  39. Nano Lett. 2009 Dec;9(12):4544-7 [PMID: 19842692]
  40. Science. 2013 Aug 16;341(6147):771-3 [PMID: 23868919]
  41. Nat Med. 2012 Dec;18(12):1835-40 [PMID: 23142818]
  42. Nat Biotechnol. 2002 Aug;20(8):816-20 [PMID: 12134166]
  43. Biosci Rep. 2015 Nov 24;36(1):e00292 [PMID: 26604322]
  44. Part Part Syst Charact. 2013 Aug;30(8):667-671 [PMID: 24077230]
  45. Nat Commun. 2013;4:2266 [PMID: 23903002]
  46. ACS Nano. 2013 Dec 23;7(12):11227-33 [PMID: 24295203]
  47. Nano Lett. 2006 Apr;6(4):875-81 [PMID: 16608302]
  48. Angew Chem Int Ed Engl. 2008;47(46):8924-8 [PMID: 18925600]
  49. Nat Nanotechnol. 2010 Sep;5(9):660-5 [PMID: 20676091]
  50. Angew Chem Int Ed Engl. 2009;48(31):5657-60 [PMID: 19554581]
  51. ACS Nano. 2018 May 22;12(5):4605-4614 [PMID: 29672022]
  52. Science. 2018 Feb 23;359(6378):866-867 [PMID: 29472467]
  53. J Am Chem Soc. 2010 May 5;132(17):5934-5 [PMID: 20373802]
  54. Nature. 2013 Apr 25;496(7446):486-9 [PMID: 23619694]
  55. Nanoscale. 2016 May 21;8(19):10124-37 [PMID: 27121263]
  56. Angew Chem Int Ed Engl. 2004 Feb 20;43(9):1115-7 [PMID: 14983449]
  57. Angew Chem Int Ed Engl. 2014 Sep 1;53(36):9550-4 [PMID: 25045009]
  58. Nat Med. 2008 Aug;14(8):869-74 [PMID: 18607350]
  59. Anal Chem. 1998 Feb 1;70(3):645-50 [PMID: 9470492]
  60. Biomaterials. 2012 Oct;33(29):7126-37 [PMID: 22789722]
  61. Adv Mater. 2011 Nov 2;23(41):4793-7 [PMID: 21953810]
  62. Adv Mater. 2009;21(30):3045-3052 [PMID: 20011128]
  63. Nat Commun. 2013;4:1752 [PMID: 23612293]
  64. Chem Rev. 2012 Nov 14;112(11):5818-78 [PMID: 23043508]
  65. J Am Chem Soc. 2013 Mar 27;135(12):4620-3 [PMID: 23510406]
  66. J Am Chem Soc. 2008 Nov 19;130(46):15573-80 [PMID: 18950167]
  67. Sensors (Basel). 2012;12(2):2162-74 [PMID: 22438758]
  68. ACS Nano. 2013 Apr 23;7(4):3287-96 [PMID: 23473444]
  69. Contrast Media Mol Imaging. 2015 Jul-Aug;10(4):245-65 [PMID: 25355685]
  70. Nat Med. 2007 Jan;13(1):95-9 [PMID: 17187073]
  71. Adv Mater. 2010 Dec 1;22(45):5168-72 [PMID: 20859943]
  72. Biosens Bioelectron. 2000 Jan;14(10-11):805-13 [PMID: 10945455]
  73. Trends Biotechnol. 2011 Jul;29(7):323-32 [PMID: 21489647]
  74. Nano Lett. 2012 Sep 12;12(9):4722-8 [PMID: 22845848]
  75. Chem Rev. 2010 May 12;110(5):2921-59 [PMID: 20067234]
  76. Biosens Bioelectron. 1998 Oct 1;13(7-8):731-9 [PMID: 9828367]
  77. Nat Nanotechnol. 2013 May;8(5):369-75 [PMID: 23644570]
  78. Angew Chem Int Ed Engl. 2011 May 9;50(20):4663-6 [PMID: 21495138]
  79. Nano Lett. 2010 Nov 10;10(11):4607-13 [PMID: 20939602]
  80. Drug Discov Today. 2014 Apr;19(4):474-81 [PMID: 24140592]
  81. Nat Nanotechnol. 2011 May;6(5):314-20 [PMID: 21478869]
  82. J Am Chem Soc. 2011 Mar 9;133(9):2955-61 [PMID: 21314118]
  83. J Am Chem Soc. 2004 Jul 14;126(27):8394-5 [PMID: 15237993]
  84. Acc Chem Res. 2009 Jul 21;42(7):948-57 [PMID: 19265438]
  85. Theranostics. 2012;2(1):55-65 [PMID: 22272219]
Journal Article Review
Article has an altmetric score of 1

Word Cloud

Created with Highcharts 10.0.0magneticMagneticdiagnosticsdetectioncannanomaterialsbiologicalsensingimagingdevelopmentssensorsbiomedicalnanoparticlesvivoSensitivequantitativecharacterizationclinicallyrelevantbiomarkersfacilitatediseasediagnosistreatmentevaluationbiosensingstrategiesrecentlyreceivedconsiderableattentionsignalsexperiencelittleinterferencenativebackgroundmoleculesnegligiblesusceptibilitiesthusappeartransparentexternalfieldsuniquepropertyapplieddeeptissuewellpoint-of-careexploitmodenewadvancementsmaterialsynthesestechnologiesmadereviewfocusesrecentimagecontrastagentsdiagnosticenabledprecisecontrolnanomaterialpropertiesalsoexpandedreachDesignsynthesisNPsexminiaturized

Similar Articles

Cited By (7)