OpenLB
Open Library of Bioscience
Advanced Search
Child development perspectives
Dec, 2018;12 (4): 240-246.

What Factors Facilitate Resilience in Developmental Dyslexia? Examining Protective and Compensatory Mechanisms Across the Neurodevelopmental Trajectory.

Xi Yu, Jennifer Zuk, Nadine Gaab
Author Information
  1. Xi Yu: Boston Children's Hospital.
  2. Jennifer Zuk: Boston Children's Hospital.
  3. Nadine Gaab: Boston Children's Hospital.
PMID: 30510595 DOI: 10.1111/cdep.12293

Abstract

Developmental dyslexia is a specific learning disability characterized by deficits reading single words. Dyslexia is heritable and has been associated with neural alterations in regions of the left hemisphere in the brain. Cognitive and neural atypicalities have been observed before children with familial risk for dyslexia begin reading, yet children who are at risk subsequently develop reading abilities on a continuum from good to poor. Of those children who develop good reading skills, what factors are associated with more successful outcomes? In this article, we review findings describing genetic, cognitive, neurobiological, and environmental factors that facilitate reading development and propose a model of neural pathways to support successful reading development in at-risk children. This research can inform educational and clinical strategies to support at-risk children. Investigating factors that contribute to the variance in behavioral outcomes among at-risk children may help us understand developmental disorders and associated etiological, compensatory, and protective factors.

Keywords

brain development developmental disorders developmental dyslexia learning disabilities neuroimaging reading resilience

References

  1. Neurosci Biobehav Rev. 2012 Jul;36(6):1532-52 [PMID: 22516793]
  2. Brain Lang. 2015 Jun-Jul;145-146:23-33 [PMID: 25935827]
  3. J Commun Disord. 2001 Nov-Dec;34(6):479-92 [PMID: 11725860]
  4. Child Dev Perspect. 2015 Mar 1;7(1):1-5 [PMID: 26290678]
  5. Mayo Clin Proc. 2001 Nov;76(11):1081-92 [PMID: 11702896]
  6. Psychol Bull. 2016 May;142(5):498-545 [PMID: 26727308]
  7. Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):361-6 [PMID: 21173250]
  8. Front Hum Neurosci. 2014 Jun 02;8:346 [PMID: 24920944]
  9. Annu Rev Neurosci. 2007;30:475-503 [PMID: 17600524]
  10. Child Dev. 2001 May-Jun;72(3):816-33 [PMID: 11405584]
  11. Neuroimage. 2016 May 1;131:55-72 [PMID: 26318050]
  12. PLoS One. 2014 Jan 10;9(1):e83668 [PMID: 24427278]
  13. Int J Lang Commun Disord. 2012 Jan-Feb;47(1):27-34 [PMID: 22268899]
  14. Eur J Hum Genet. 2014 May;22(5):675-80 [PMID: 24022301]
  15. J Learn Disabil. 2012 Jan-Feb;45(1):31-46 [PMID: 22064950]
  16. Curr Opin Behav Sci. 2016 Aug;10:133-141 [PMID: 27747263]
  17. Science. 2013 Dec 6;342(6163):1251-4 [PMID: 24311693]
  18. Ann Dyslexia. 2008 Jun;58(1):1-14 [PMID: 18483867]
  19. J Learn Disabil. 2010 Jul-Aug;43(4):308-21 [PMID: 20479461]
  20. Mol Genet Metab. 2013 Nov;110(3):201-12 [PMID: 23916419]
  21. Dev Sci. 2013 Mar;16(2):234-248 [PMID: 23432833]
  22. Annu Rev Psychol. 2012;63:427-52 [PMID: 21838545]
  23. Psychol Sci. 2018 Mar;29(3):418-428 [PMID: 29346032]
  24. Ann Dyslexia. 2016 Oct;66(3):337-360 [PMID: 27550556]
  25. Psychol Bull. 2012 Mar;138(2):322-52 [PMID: 22250824]
  26. Neuroscience. 2011 Sep 8;190:398-408 [PMID: 21689730]
  27. Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):2156-61 [PMID: 22308323]
  28. Hum Brain Mapp. 2013 Nov;34(11):3055-65 [PMID: 22711189]
  29. Nat Neurosci. 2015 May;18(5):773-8 [PMID: 25821911]
  30. Neuroreport. 2008 Oct 29;19(16):1627-31 [PMID: 18806688]
  31. Cereb Cortex. 2017 Feb 1;27(2):1027-1036 [PMID: 26643353]
  32. Transl Psychiatry. 2017 Jul 25;7(7):e1182 [PMID: 28742079]
  33. Mol Psychiatry. 2011 Apr;16(4):365-82 [PMID: 20956978]
  34. Cereb Cortex. 2017 Apr 1;27(4):2469-2485 [PMID: 27114172]
  35. Nat Neurosci. 2006 Oct;9(10):1213-7 [PMID: 17001339]
  36. Wiley Interdiscip Rev Cogn Sci. 2016 Mar-Apr;7(2):156-76 [PMID: 26836227]
  37. Curr Opin Neurobiol. 2013 Feb;23(1):37-42 [PMID: 23040541]
  38. Twin Res Hum Genet. 2007 Jun;10(3):434-9 [PMID: 17564501]
  39. Neurophysiol Clin. 2012 Jan-Feb;42(1-2):35-41 [PMID: 22200340]
  40. Neuroimage. 2011 Jun 1;56(3):1735-42 [PMID: 21338695]
  41. Front Neurosci. 2014 Sep 04;8:276 [PMID: 25249931]

Grants

  1. R01 HD065762/NICHD NIH HHS
  2. R01 HD067312/NICHD NIH HHS
  3. T32 DC000038/NIDCD NIH HHS
Journal Article
Article has an altmetric score of 35

Word Cloud

Created with Highcharts 10.0.0readingchildrenfactorsdyslexiaassociatedneuraldevelopmentat-riskdevelopmentalDevelopmentallearningbrainriskdevelopgoodsuccessfulsupportdisordersspecificdisabilitycharacterizeddeficitssinglewordsDyslexiaheritablealterationsregionslefthemisphereCognitiveatypicalitiesobservedfamilialbeginyetsubsequentlyabilitiescontinuumpoorskillsoutcomes?articlereviewfindingsdescribinggeneticcognitiveneurobiologicalenvironmentalfacilitateproposemodelpathwaysresearchcaninformeducationalclinicalstrategiesInvestigatingcontributevariancebehavioraloutcomesamongmayhelpusunderstandetiologicalcompensatoryprotectiveFactorsFacilitateResilienceDyslexia?ExaminingProtectiveCompensatoryMechanismsAcrossNeurodevelopmentalTrajectorydisabilitiesneuroimagingresilience

Similar Articles

Cited By