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European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Feb, 2019;276 (2): 567-574.

Outcome of patients following neo-adjuvant chemotherapy for unresectable cervical nodes in head and neck squamous cell carcinomas.

Akshat Malik, Burhanuddin N Qayyumi, Manish Mair, Hitesh Singhavi, Yash Mathur, Deepa Nair, Sarbani Ghosh-Laskar, Jai Prakash Agrawal, Kumar Prabash, Pankaj Chaturvedi
Author Information
  1. Akshat Malik: Department of Head and Neck Surgical Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Dr. E Borges Road, Parel, Mumbai, 400012, India.
  2. Burhanuddin N Qayyumi: Department of Head and Neck Surgical Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Dr. E Borges Road, Parel, Mumbai, 400012, India.
  3. Manish Mair: Department of Head and Neck Surgical Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Dr. E Borges Road, Parel, Mumbai, 400012, India.
  4. Hitesh Singhavi: Department of Head and Neck Surgical Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Dr. E Borges Road, Parel, Mumbai, 400012, India.
  5. Yash Mathur: Department of Head and Neck Surgical Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Dr. E Borges Road, Parel, Mumbai, 400012, India.
  6. Deepa Nair: Department of Head and Neck Surgical Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Dr. E Borges Road, Parel, Mumbai, 400012, India.
  7. Sarbani Ghosh-Laskar: Department of Radiation Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Dr. E Borges Road, Parel, Mumbai, 400012, India.
  8. Jai Prakash Agrawal: Department of Radiation Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Dr. E Borges Road, Parel, Mumbai, 400012, India.
  9. Kumar Prabash: Department of Medical Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Dr. E Borges Road, Parel, Mumbai, 400012, India.
  10. Pankaj Chaturvedi: Department of Head and Neck Surgical Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Dr. E Borges Road, Parel, Mumbai, 400012, India. chaturvedi.pankaj@gmail.com.
PMID: 30556102 DOI: 10.1007/s00405-018-5253-4

Abstract

BACKGROUND: This study was undertaken to assess the effects of neo-adjuvant chemotherapy (NACT) on patients with head and neck squamous cell carcinoma (HNSCC) having advanced unresectable cervical nodal metastasis.
METHODOLOGY: A retrospective cohort study was conducted to assess the response of unresectable nodes to NACT in a pragmatic manner. Patients were grouped according to the response noted and the treatment offered after chemotherapy. The median survival amongst the patients in these groups was compared.
RESULTS: The study included 51 patients. Oral cavity was the commonest site (67.2%). Favourable nodal response was seen in 64.7% of the patients. Up to 87.9% of the nodal responders were amenable to curative intent therapy. The overall survival of patients undergoing surgery, definitive chemoradiotherapy, palliative chemotherapy and palliative radiotherapy was 24, 13, 10 and 9 months, respectively.
CONCLUSION: NACT may be utilized in HNSCC with advanced inoperable nodal disease to make them amenable to definitive therapy.

Keywords

Head and neck cancers Induction chemotherapy Response Unresectable nodes

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MeSH Term

Adult
Aged
Carcinoma, Squamous Cell
Chemoradiotherapy
Chemotherapy, Adjuvant
Cohort Studies
Female
Head and Neck Neoplasms
Humans
Lymph Nodes
Lymphatic Metastasis
Male
Middle Aged
Neoadjuvant Therapy
Radiotherapy, Adjuvant
Retrospective Studies
Young Adult
Journal Article

Word Cloud

Created with Highcharts 10.0.0patientschemotherapynodalstudyNACTneckunresectableresponsenodesassessneo-adjuvantheadsquamouscellHNSCCadvancedcervicalsurvivalamenabletherapydefinitivepalliativeBACKGROUND:undertakeneffectscarcinomametastasisMETHODOLOGY:retrospectivecohortconductedpragmaticmannerPatientsgroupedaccordingnotedtreatmentofferedmedianamongstgroupscomparedRESULTS:included51Oralcavitycommonestsite672%Favourableseen647%879%responderscurativeintentoverallundergoingsurgerychemoradiotherapyradiotherapy2413109 monthsrespectivelyCONCLUSION:mayutilizedinoperablediseasemakeOutcomefollowingcarcinomasHeadcancersInductionResponseUnresectable

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