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Immunology
04, 2019;156 (4): 319-328.

Conserved and variable natural killer cell receptors: diverse approaches to viral infections.

Leidy Y Bastidas-Legarda, Salim I Khakoo
Author Information
  1. Leidy Y Bastidas-Legarda: Faculty of Medicine, Clinical and Experimental Sciences, Southampton General Hospital, University of Southampton, Southampton, UK.
  2. Salim I Khakoo: Faculty of Medicine, Clinical and Experimental Sciences, Southampton General Hospital, University of Southampton, Southampton, UK. ORCID
PMID: 30570753 DOI: 10.1111/imm.13039

Abstract

Natural killer (NK) cells are lymphocytes of the innate immune system with essential roles during viral infections. NK cell functions are mediated through a repertoire of non-rearranging inhibitory and activating receptors that interact with major histocompatibility complex (MHC)-peptide complexes on the surface of infected cells. Recent work studying the conserved CD94-NKG2A and variable killer cell immunoglobulin-like receptor-MHC systems suggest that these two receptor families may have subtly different properties in terms of interactions with MHC class I bound peptides, and in recognition of down-regulation of MHC class I. In this review, we discuss how these properties generate diversity in the NK cell response to viruses.

Keywords

conserved natural killer cells polymorphic receptor-ligand viral infection

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Grants

  1. /Medical Research Council

MeSH Term

Humans
Receptors, Natural Killer Cell
Virus Diseases

Chemicals

Receptors, Natural Killer Cell
Journal Article Research Support, Non-U.S. Gov't Review
Article has an altmetric score of 4

Word Cloud

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