Coherently broadened, high-repetition-rate laser for stimulated Raman scattering-spectroscopic optical coherence tomography.

Francisco E Robles, Heiko Linnenbank, Florian Mörz, Patrick Ledwig, Tobias Steinle, Harald Giessen
Author Information

Abstract

We present a novel light source specifically tailored for stimulated Raman scattering-spectroscopic optical coherence tomography (SRS-SOCT), which is, to the best of our knowledge, a novel molecular imaging method that combines the molecular sensitivity of SRS with the spatial and spectral multiplexing capabilities of SOCT. The novel laser consists of an 8 W, 450 fs Yb:KGW oscillator, with a repetition rate of 40 MHz, which delivers the Stokes beam for SRS-SOCT and also pumps and amplifies an optical parametric oscillator (OPO). The output of the amplified OPO is then frequency doubled and coherently broadened using a custom-made tapered fiber that generates bandwidth pulses >40  nm, compressible to <50  fs, with the average power over 150 mW, near the shot-noise limit above 250 kHz. The broadened and compressed pulse simultaneously serves as the pump beam and SOCT light source for SRS-SOCT. This light source is assessed for SRS-SOCT, and its implications for other imaging methods are discussed.

References

  1. J Opt Soc Am A Opt Image Sci Vis. 2005 Aug;22(8):1492-9 [PMID: 16134843]
  2. Opt Lett. 2001 Mar 1;26(5):304-6 [PMID: 18040309]
  3. Opt Lett. 2000 Oct 1;25(19):1415-7 [PMID: 18066233]
  4. Opt Express. 2004 May 31;12(11):2423-8 [PMID: 19475078]
  5. Opt Express. 2006 May 1;14(9):3942-51 [PMID: 19516542]
  6. Opt Lett. 1993 Dec 1;18(23):1996 [PMID: 19829470]
  7. J Am Chem Soc. 2012 Feb 29;134(8):3623-6 [PMID: 22316340]
  8. Nat Photonics. 2011;5(2):103-109 [PMID: 23015809]
  9. Opt Express. 2013 Apr 22;21(8):9353-64 [PMID: 23609646]
  10. IEEE J Sel Top Quantum Electron. 2012 May;18(3):null [PMID: 24187481]
  11. Opt Lett. 2014 Aug 15;39(16):4788-91 [PMID: 25121875]
  12. Biomed Opt Express. 2015 May 27;6(6):2268-82 [PMID: 26114045]
  13. J Lightwave Technol. 2015 May 1;33(9):1814-1820 [PMID: 26166939]
  14. Light Sci Appl. 2015;4:null [PMID: 26167336]
  15. Opt Express. 2015 Sep 7;23(18):23960-7 [PMID: 26368486]
  16. Opt Express. 2016 Jan 11;24(1):485-98 [PMID: 26832279]
  17. Nat Photonics. 2016 Aug;10(8):534-540 [PMID: 27668009]
  18. Optica. 2017 Feb;4(2):243-246 [PMID: 29302608]
  19. Light Sci Appl. 2016 Oct 07;5(10):e16149 [PMID: 30167121]

Grants

  1. R21 CA223853/NCI NIH HHS

Word Cloud

Created with Highcharts 10.0.0SRS-SOCTnovellightsourceopticalbroadenedstimulatedRamanscattering-spectroscopiccoherencetomographymolecularimagingSOCTlaseroscillatorbeamOPOpresentspecificallytailoredbestknowledgemethodcombinessensitivitySRSspatialspectralmultiplexingcapabilitiesconsists8 W450 fsYb:KGWrepetitionrate40 MHzdeliversStokesalsopumpsamplifiesparametricoutputamplifiedfrequencydoubledcoherentlyusingcustom-madetaperedfibergeneratesbandwidthpulses>40  nmcompressible<50  fsaveragepower150 mWnearshot-noiselimit250 kHzcompressedpulsesimultaneouslyservespumpassessedimplicationsmethodsdiscussedCoherentlyhigh-repetition-rate

Similar Articles

Cited By