OpenLB
Open Library of Bioscience
Advanced Search
Cancers
Jan 15, 2019;11 (1):

Predicting VTE in Cancer Patients: Candidate Biomarkers and Risk Assessment Models.

Silvia Riondino, Patrizia Ferroni, Fabio Massimo Zanzotto, Mario Roselli, Fiorella Guadagni
Author Information
  1. Silvia Riondino: Interinstitutional Multidisciplinary Biobank, IRCCS San Raffaele Pisana, 00166 Rome, Italy. silvia.riondino@sanraffaele.it. ORCID
  2. Patrizia Ferroni: Interinstitutional Multidisciplinary Biobank, IRCCS San Raffaele Pisana, 00166 Rome, Italy. patrizia.ferroni@sanraffaele.it. ORCID
  3. Fabio Massimo Zanzotto: Department of Enterprise Engineering, University of Rome "Tor Vergata", 00133 Rome, Italy. fabio.massimo.zanzotto@uniroma2.it. ORCID
  4. Mario Roselli: Department of Systems Medicine, Medical Oncology, University of Rome Tor Vergata, 00133 Rome, Italy. mario.roselli@uniroma2.it.
  5. Fiorella Guadagni: Interinstitutional Multidisciplinary Biobank, IRCCS San Raffaele Pisana, 00166 Rome, Italy. fiorella.guadagni@sanraffaele.it.
PMID: 30650562 DOI: 10.3390/cancers11010095

Abstract

Risk prediction of chemotherapy-associated venous thromboembolism (VTE) is a compelling challenge in contemporary oncology, as VTE may result in treatment delays, impaired quality of life, and increased mortality. Current guidelines do not recommend thromboprophylaxis for primary prevention, but assessment of the patient's individual risk of VTE prior to chemotherapy is generally advocated. In recent years, efforts have been devoted to building accurate predictive tools for VTE risk assessment in cancer patients. This review focuses on candidate biomarkers and prediction models currently under investigation, considering their advantages and disadvantages, and discussing their diagnostic performance and potential pitfalls.

Keywords

biomarkers clinical decision systems machine learning risk assessment models venous thromboembolism

References

Thromb Haemost. 2000 Jan;83(1):5-9 [PMID: 10669145]
Pathol Oncol Res. 2000;6(1):38-41 [PMID: 10749586]
N Engl J Med. 2000 Aug 17;343(7):457-62 [PMID: 10950667]
Am J Med. 2000 Oct 1;109(5):357-61 [PMID: 11020391]
Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13835-40 [PMID: 11095738]
Am J Med. 2001 Feb 1;110(2):91-6 [PMID: 11165549]
Thromb Res. 2002 Jan 1;105(1):43-7 [PMID: 11864706]
Arch Intern Med. 2002 Jun 10;162(11):1245-8 [PMID: 12038942]
Blood. 2002 Nov 15;100(10):3484-8 [PMID: 12393647]
Am J Med. 2002 Dec 1;113(8):636-42 [PMID: 12505113]
Cancer Metastasis Rev. 1992 Nov;11(3-4):237-48 [PMID: 1423816]
N Engl J Med. 2003 Sep 25;349(13):1227-35 [PMID: 14507948]
Thromb Res. 2003;111(3):149-53 [PMID: 14678812]
Br J Haematol. 2004 Feb;124(4):504-10 [PMID: 14984502]
J Thromb Haemost. 2004 Apr;2(4):619-22 [PMID: 15102017]
Arch Intern Med. 2004 May 10;164(9):963-8 [PMID: 15136304]
Ann Oncol. 2004 Nov;15(11):1622-6 [PMID: 15520062]
J Thromb Haemost. 2005 Mar;3(3):589-90 [PMID: 15748257]
Front Biosci. 2006 Jan 01;11:59-80 [PMID: 16146714]
Cancer. 2005 Dec 15;104(12):2822-9 [PMID: 16284987]
Cancer Res. 2005 Dec 1;65(23):10794-800 [PMID: 16322225]
J Thromb Haemost. 2006 Mar;4(3):529-35 [PMID: 16460435]
Arch Intern Med. 2006 Feb 27;166(4):458-64 [PMID: 16505267]
Arch Immunol Ther Exp (Warsz). 2006 Mar-Apr;54(2):75-84 [PMID: 16648968]
Br J Haematol. 2006 Aug;134(4):399-405 [PMID: 16882132]
J Thromb Haemost. 2007 Mar;5(3):520-7 [PMID: 17166244]
J Thromb Haemost. 2007 Jan;5(1):70-4 [PMID: 17239164]
Curr Med Chem. 2007;14(20):2170-80 [PMID: 17691955]
Blood. 2008 May 15;111(10):4902-7 [PMID: 18216292]
Thromb Res. 2008;122(5):604-9 [PMID: 18262600]
Blood. 2008 Jul 1;112(1):82-9 [PMID: 18316629]
Blood. 2008 Oct 1;112(7):2703-8 [PMID: 18539899]
J Thromb Haemost. 2008 Sep;6(9):1482-7 [PMID: 18573186]
Chest. 2008 Jun;133(6 Suppl):381S-453S [PMID: 18574271]
Clin Chim Acta. 2009 Jan;399(1-2):88-91 [PMID: 18835553]
Thromb Haemost. 2008 Oct;100(4):663-9 [PMID: 18841290]
Semin Thromb Hemost. 2008 Jul;34(5):445-50 [PMID: 18956284]
Thromb Haemost. 2008 Nov;100(5):905-11 [PMID: 18989537]
Arterioscler Thromb Vasc Biol. 2009 Mar;29(3):316-20 [PMID: 19228604]
Blood Coagul Fibrinolysis. 2009 Apr;20(3):170-5 [PMID: 19276795]
Thromb Res. 2009;123 Suppl 4:S18-21 [PMID: 19303497]
Dis Colon Rectum. 2009 Mar;52(3):446-51 [PMID: 19333044]
Am J Hematol. 2009 Jul;84(7):408-13 [PMID: 19437507]
J Thromb Haemost. 2009 Aug;7(8):1421-3 [PMID: 19500241]
Annu Rev Cell Dev Biol. 2010;26:363-96 [PMID: 19575676]
J Clin Oncol. 2009 Sep 1;27(25):4124-9 [PMID: 19636003]
Ann Oncol. 2010 Apr;21(4):871-6 [PMID: 19713246]
J Clin Oncol. 2009 Oct 10;27(29):4834-8 [PMID: 19738116]
Arterioscler Thromb Vasc Biol. 2009 Dec;29(12):2176-81 [PMID: 19778945]
Clin Cancer Res. 2009 Nov 15;15(22):6830-40 [PMID: 19861441]
J Thromb Haemost. 2010 Jan;8(1):114-20 [PMID: 19889150]
Am J Med. 2010 Jan;123(1):60-5 [PMID: 20102993]
Ann Oncol. 2010 Aug;21(8):1651-6 [PMID: 20129998]
BMJ. 2010 Mar 30;340:c1475 [PMID: 20354012]
Thromb Res. 2010 Jun;125(6):518-22 [PMID: 20451960]
Semin Cancer Biol. 2010 Jun;20(3):169-77 [PMID: 20452433]
J Thromb Haemost. 2010 Aug;8(8):1702-9 [PMID: 20553384]
Thromb Res. 2010 Aug;126(2):113-8 [PMID: 20684071]
Cancer Epidemiol Biomarkers Prev. 2010 Oct;19(10):2605-10 [PMID: 20729288]
Thromb Haemost. 2010 Nov;104(5):1049-54 [PMID: 20806119]
Blood. 2010 Dec 9;116(24):5377-82 [PMID: 20829374]
Ann Hematol. 2011 Apr;90(4):447-53 [PMID: 20981426]
Thromb Haemost. 2011 Mar;105(3):396-408 [PMID: 21174005]
Thromb Res. 2011 May;127(5):473-7 [PMID: 21256535]
Nat Rev Cancer. 2011 Feb;11(2):123-34 [PMID: 21258396]
Thromb Haemost. 2011 May;105(5):931-2 [PMID: 21359410]
Circ Res. 2011 May 13;108(10):1284-97 [PMID: 21566224]
Thromb Res. 2012 Jan;129(1):80-5 [PMID: 21737126]
J Clin Oncol. 2011 Sep 1;29(25):3466-73 [PMID: 21810688]
Blood. 2011 Sep 29;118(13):3680-3 [PMID: 21832279]
Blood Transfus. 2011 May;9 Suppl 2:s1-2 [PMID: 21839027]
J Thromb Haemost. 2011 Nov;9(11):2251-61 [PMID: 21883880]
Ann Oncol. 2011 Sep;22 Suppl 6:vi85-92 [PMID: 21908511]
Thromb Res. 2012 May;129(5):e171-6 [PMID: 21962722]
J Transl Med. 2011 Oct 20;9:179 [PMID: 22013950]
Chest. 2012 Feb;141(2 Suppl):7S-47S [PMID: 22315257]
Support Care Cancer. 2012 Nov;20(11):2713-20 [PMID: 22322591]
N Engl J Med. 2012 Feb 16;366(7):610-8 [PMID: 22335738]
Br J Haematol. 2012 Jun;157(6):653-63 [PMID: 22530883]
Thromb Haemost. 2012 Jul;108(1):160-5 [PMID: 22535219]
J Thromb Haemost. 2012 Jul;10(7):1355-62 [PMID: 22537188]
Intern Emerg Med. 2012 Jun;7(3):291-2 [PMID: 22547369]
Int J Colorectal Dis. 2012 Dec;27(12):1561-7 [PMID: 22581210]
Clin Lung Cancer. 2012 Nov;13(6):482-7 [PMID: 22591606]
Genes Dev. 2012 Jun 15;26(12):1287-99 [PMID: 22713869]
Cancer Res. 2012 Sep 15;72(18):4662-71 [PMID: 22836751]
Cancer Treat Rev. 2013 Feb;39(1):89-96 [PMID: 22858249]
Cancer. 2013 Feb 1;119(3):648-55 [PMID: 22893596]
Thromb Haemost. 2012 Dec;108(6):1109-23 [PMID: 23014768]
Thromb Haemost. 2012 Dec;108(6):1243-5 [PMID: 23052961]
Thromb Res. 2012 Dec;130(6):e279-82 [PMID: 23079295]
J Thromb Haemost. 2013 Jan;11(1):56-70 [PMID: 23217107]
Int J Cancer. 2013 Sep 1;133(5):1253-8 [PMID: 23404208]
J Invest Dermatol. 2014 Jan;134(1):176-182 [PMID: 23812302]
Thromb Res. 2014 Jan;133(1):17-24 [PMID: 24012101]
PLoS One. 2013 Sep 04;8(9):e73447 [PMID: 24023876]
Dtsch Med Wochenschr. 2013 Oct;138(41):2084-8 [PMID: 24085361]
J Biol Chem. 1985 Sep 15;260(20):11107-14 [PMID: 2411729]
Oncologist. 2013;18(12):1321-9 [PMID: 24212499]
J Natl Compr Canc Netw. 2013 Nov;11(11):1402-29 [PMID: 24225973]
Thromb Haemost. 2014 Apr 1;111(4):670-8 [PMID: 24306221]
Thromb Haemost. 2014 Apr 1;111(4):590-7 [PMID: 24452853]
Clin Exp Immunol. 2014 Jul;177(1):253-60 [PMID: 24580121]
PLoS One. 2014 Mar 18;9(3):e92011 [PMID: 24642868]
Oncologist. 2014 May;19(5):562-7 [PMID: 24710308]
Cancer Metastasis Rev. 2014 Sep;33(2-3):771-89 [PMID: 24748012]
Ethn Dis. 2014 Spring;24(2):169-74 [PMID: 24804362]
Cancer Growth Metastasis. 2014 Jun 02;7:9-18 [PMID: 24926201]
Blood Coagul Fibrinolysis. 2015 Apr;26(3):255-60 [PMID: 24991946]
Int J Cancer. 2015 Mar 1;136(5):1234-40 [PMID: 25042739]
J Hematol Oncol. 2014 Aug 01;7:54 [PMID: 25084809]
Haematologica. 2014 Oct;99(10):1638-44 [PMID: 25085351]
J Thromb Haemost. 2014 Nov;12(11):1928-31 [PMID: 25208230]
Thromb Res. 2014 Nov;134(5):1008-13 [PMID: 25234407]
J Thromb Haemost. 2014 Dec;12(12):2049-53 [PMID: 25256037]
Thromb Res. 2015 Aug;136(2):212-5 [PMID: 25533129]
J Clin Oncol. 2015 Feb 20;33(6):654-6 [PMID: 25605844]
Cancer Res Treat. 2015 Oct;47(4):670-5 [PMID: 25672586]
Hematology Am Soc Hematol Educ Program. 2014 Dec 5;2014(1):410-7 [PMID: 25696887]
Cytometry A. 2016 Feb;89(2):111-22 [PMID: 25704723]
Eur J Cancer. 2015 Sep;51(14):1978-88 [PMID: 26238017]
Thromb Res. 2015 Dec;136(6):1099-102 [PMID: 26260645]
Thromb Haemost. 2015 Aug 31;114(3):449-58 [PMID: 26293514]
J Thromb Haemost. 2016 Feb;14(2):294-305 [PMID: 26662117]
Oncologist. 2016 Feb;21(2):252-7 [PMID: 26764252]
J Thromb Thrombolysis. 2016 Jan;41(1):3-14 [PMID: 26780736]
J Thromb Thrombolysis. 2016 Apr;41(3):539-40 [PMID: 26931102]
Endocr Relat Cancer. 2016 Jun;23(6):L25-8 [PMID: 27185869]
J Thromb Haemost. 2016 Sep;14(9):1773-8 [PMID: 27273134]
Hematol Oncol. 2017 Dec;35(4):456-464 [PMID: 27377517]
Br J Cancer. 2016 Jul 26;115(3):332-8 [PMID: 27404454]
Med Decis Making. 2017 Feb;37(2):234-242 [PMID: 27491558]
IEEE Trans Biomed Eng. 2017 Feb;64(2):263-273 [PMID: 27740470]
Curr Med Chem. 2017;24(24):2589-2601 [PMID: 27758714]
Semin Thromb Hemost. 2016 Nov;42(8):808-820 [PMID: 27764878]
Thromb Res. 2016 Dec;148:63-69 [PMID: 27815968]
J Thromb Haemost. 2017 Mar;15(3):590-591 [PMID: 27992116]
Thromb Res. 2017 Feb;150:30-32 [PMID: 28002757]
Cardiovasc Hematol Agents Med Chem. 2017;15(1):3-16 [PMID: 28137223]
Oncologist. 2017 May;22(5):601-608 [PMID: 28424324]
Crit Rev Oncol Hematol. 2017 May;113:83-89 [PMID: 28427527]
Int J Lab Hematol. 2017 May;39 Suppl 1:98-103 [PMID: 28447414]
World J Gastrointest Oncol. 2017 Apr 15;9(4):176-183 [PMID: 28451065]
Oncologist. 2017 Oct;22(10):1222-1231 [PMID: 28550032]
Haematologica. 2017 Sep;102(9):1494-1501 [PMID: 28550192]
Medicine (Baltimore). 2017 Jun;96(25):e7062 [PMID: 28640083]
BMC Cancer. 2017 Aug 7;17(1):527 [PMID: 28784104]
World J Gastroenterol. 2017 Jul 28;23(28):5187-5195 [PMID: 28811713]
Thromb Res. 2017 Oct;158:49-58 [PMID: 28822240]
J Med Syst. 2017 Oct 14;41(11):183 [PMID: 29032458]
Eur J Intern Med. 2017 Dec;46:e42-e44 [PMID: 29046258]
Dis Markers. 2017;2017:8781379 [PMID: 29104344]
Dis Markers. 2017;2017:3041565 [PMID: 29109595]
Cancer. 1989 Apr 1;63(7):1303-7 [PMID: 2920359]
Support Care Cancer. 2018 Jun;26(6):2049-2056 [PMID: 29353416]
Otolaryngol Head Neck Surg. 2018 Jul;159(1):85-91 [PMID: 29406795]
Br J Cancer. 2018 Apr;118(8):1056-1061 [PMID: 29588512]
Oncotarget. 2018 Mar 30;9(24):16883-16890 [PMID: 29682191]
Thromb Res. 2018 Apr;164 Suppl 1:S40-S47 [PMID: 29703484]
Oncotarget. 2018 Apr 20;9(30):21190-21200 [PMID: 29765530]
Lancet Haematol. 2018 Jul;5(7):e289-e298 [PMID: 29885940]
ESMO Open. 2018 Jul 23;3(5):e000363 [PMID: 30094068]
Lancet Haematol. 2018 Sep;5(9):e391 [PMID: 30172343]
Thromb Haemost. 2018 Nov;118(11):1875-1884 [PMID: 30296815]
N Engl J Med. 2018 Dec 4;:null [PMID: 30511879]
Haematologica. 2019 Jan 3;:null [PMID: 30606788]
J Clin Invest. 1981 Jun;67(6):1665-71 [PMID: 7016920]
Lancet. 1995 Jan 21;345(8943):152-5 [PMID: 7823669]
Blood. 1993 May 15;81(10):2554-65 [PMID: 8490169]
Thromb Haemost. 1997 Jun;77(6):1081-5 [PMID: 9241736]
Haemostasis. 1997 May-Jun;27(3):112-8 [PMID: 9306127]
Thromb Haemost. 1998 Jan;79(1):38-41 [PMID: 9459319]

Grants

  1. PNR 2015-2020 ARS01_01163 PerMedNet - CUP B66G18000220005/European Social Fund
  2. "HORIZON 2020" PON I&C 2014-2020 - F/050383/01-03/X32/European Social Fund
Journal Article Review

Word Cloud

Similar Articles

Cited By