OpenLB
Open Library of Bioscience
Advanced Search
Frontiers in molecular neuroscience
2018;11 493.

Neuropeptides Exert Neuroprotective Effects in Alzheimer's Disease.

Xin-Yi Chen, Yi-Feng Du, Lei Chen
Author Information
  1. Xin-Yi Chen: Department of Physiology and Pathophysiology, Qingdao University, Qingdao, China.
  2. Yi-Feng Du: Department of Neurology, Provincial Hospital Affiliated to Shandong University, Jinan, China.
  3. Lei Chen: Department of Physiology and Pathophysiology, Qingdao University, Qingdao, China.
PMID: 30687008 DOI: 10.3389/fnmol.2018.00493

Abstract

Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by cognitive deficits and neuronal loss. Deposition of beta-amyloid peptide (Aβ) causes neurotoxicity through the formation of plaques in brains of Alzheimer's disease. Numerous studies have indicated that the neuropeptides including ghrelin, neurotensin, pituitary adenylate cyclase-activating polypeptide (PACAP), neuropeptide Y, substance P and orexin are closely related to the pathophysiology of Alzheimer's disease. The levels of neuropeptides and their receptors change in Alzheimer's disease. These neuropeptides exert neuroprotective roles mainly through preventing Aβ accumulation, increasing neuronal glucose transport, increasing the production of neurotrophins, inhibiting endoplasmic reticulum stress and autophagy, modulating potassium channel activity and hippocampal long-term potentiation. Therefore, the neuropeptides may function as potential drug targets in the prevention and cure of Alzheimer's disease.

Keywords

Alzheimer's disease ghrelin neuropeptide neuropeptide Y neurotensin orexin pituitary adenylate cyclase-activating polypeptide substance P

References

  1. Brain Res Bull. 1999 Nov 1;50(4):251-62 [PMID: 10582523]
  2. Neurosci Lett. 2001 Feb 16;299(1-2):117-20 [PMID: 11166952]
  3. Cereb Cortex. 2001 Jun;11(6):490-7 [PMID: 11375910]
  4. Peptides. 2002 Aug;23(8):1471-8 [PMID: 12182949]
  5. Peptides. 2002 Sep;23(9):1683-8 [PMID: 12217429]
  6. J Comp Neurol. 2002 Nov 25;453(4):389-417 [PMID: 12389210]
  7. J Clin Psychiatry. 2002;63 Suppl 11:6-10 [PMID: 12562137]
  8. J Comp Neurol. 1992 Mar 15;317(3):283-97 [PMID: 1374440]
  9. Neurobiol Dis. 2003 Dec;14(3):579-94 [PMID: 14678773]
  10. Int Rev Neurobiol. 2004;59:327-49 [PMID: 15006494]
  11. Neuroscience. 2004;126(3):639-49 [PMID: 15183513]
  12. Neurology. 2004 Jun 8;62(11):1984-9 [PMID: 15184601]
  13. Regul Pept. 2004 Dec 15;123(1-3):43-9 [PMID: 15518892]
  14. Neurobiol Aging. 2006 Mar;27(3):377-86 [PMID: 15927307]
  15. FASEB J. 2006 Mar;20(3):512-4 [PMID: 16401644]
  16. J Physiol Paris. 2006 Mar-May;99(2-3):180-92 [PMID: 16458491]
  17. Behav Brain Res. 2006 Oct 2;173(1):47-52 [PMID: 16815564]
  18. Peptides. 2006 Oct;27(10):2415-23 [PMID: 16872718]
  19. Alzheimer Dis Assoc Disord. 1990;4(1):24-34 [PMID: 1690554]
  20. Brain Res. 1990 Dec 24;537(1-2):298-302 [PMID: 1707731]
  21. Neuroscience. 1991;41(1):41-60 [PMID: 1711654]
  22. J Neurosci. 2007 Jan 24;27(4):796-807 [PMID: 17251419]
  23. Brain Res. 2007 Apr 27;1143:199-207 [PMID: 17328871]
  24. Behav Brain Res. 2008 Feb 11;187(1):172-7 [PMID: 17977608]
  25. Ann N Y Acad Sci. 2007 Nov;1119:208-15 [PMID: 18056969]
  26. Neurosci Lett. 2008 Mar 21;434(1):1-5 [PMID: 18313848]
  27. Eur J Neurosci. 2008 Apr;27(8):2103-14 [PMID: 18412630]
  28. J Neurosci. 2009 Jan 28;29(4):1115-25 [PMID: 19176820]
  29. BMJ. 2009 Feb 05;338:b158 [PMID: 19196745]
  30. Neuropharmacology. 2010 Jan;58(1):268-76 [PMID: 19576909]
  31. Neuroscience. 1990;39(3):613-27 [PMID: 1965859]
  32. Neuroscience. 2009 Dec 15;164(3):1199-209 [PMID: 19733635]
  33. Science. 2009 Nov 13;326(5955):1005-7 [PMID: 19779148]
  34. Neuroimage. 2010 Jan 15;49(2):1205-12 [PMID: 19796695]
  35. Am J Psychiatry. 1991 Apr;148(4):484-8 [PMID: 2006695]
  36. Biol Pharm Bull. 2010;33(7):1165-9 [PMID: 20606308]
  37. J Alzheimers Dis. 2010;22(3):819-28 [PMID: 20858966]
  38. J Alzheimers Dis. 2011;23(1):147-59 [PMID: 20930280]
  39. Psychiatry Clin Neurosci. 2010 Dec;64(6):608-11 [PMID: 21029250]
  40. Neurodegener Dis. 2011;8(5):300-9 [PMID: 21346312]
  41. Neuroimage. 2011 Jun 1;56(3):890-906 [PMID: 21356315]
  42. Curr Pharm Des. 2011;17(10):962-72 [PMID: 21524257]
  43. Neurobiol Aging. 2012 Aug;33(8):1642-50 [PMID: 21546124]
  44. FASEB J. 2011 Sep;25(9):3208-18 [PMID: 21593432]
  45. J Neurochem. 2012 Jan;120 Suppl 1:46-54 [PMID: 21883223]
  46. Peptides. 2011 Nov;32(11):2225-8 [PMID: 21983104]
  47. Dement Geriatr Cogn Disord. 2011;32(3):178-81 [PMID: 22005651]
  48. Neuropharmacology. 2012 Apr;62(5-6):1954-63 [PMID: 22244942]
  49. J Neurophysiol. 2012 Aug 1;108(3):863-70 [PMID: 22552186]
  50. ACS Chem Neurosci. 2012 Apr 18;3(4):312-8 [PMID: 22860197]
  51. Mol Cell Biochem. 2013 Apr;376(1-2):189-95 [PMID: 23358924]
  52. Behav Brain Res. 2013 May 1;244:107-15 [PMID: 23396168]
  53. Neuroscience. 2013 Jun 25;241:41-51 [PMID: 23506735]
  54. J Neurosci. 2013 Mar 20;33(12):5275-84 [PMID: 23516292]
  55. Curr Pharm Des. 2013;19(38):6773-90 [PMID: 23530516]
  56. PLoS One. 2013;8(4):e60437 [PMID: 23565247]
  57. PLoS One. 2013 Jun 05;8(6):e64183 [PMID: 23755116]
  58. Sci Rep. 2013;3:2229 [PMID: 23863985]
  59. ACS Chem Neurosci. 2013 Oct 16;4(10):1371-81 [PMID: 23875773]
  60. PLoS One. 2013 Sep 27;8(9):e76497 [PMID: 24086745]
  61. J Comp Neurol. 2014 Apr 1;522(5):1132-54 [PMID: 24127055]
  62. Mol Brain. 2013 Nov 13;6:46 [PMID: 24225225]
  63. PLoS One. 2013 Nov 12;8(11):e78036 [PMID: 24265678]
  64. Bioorg Med Chem Lett. 2014 Jan 15;24(2):430-41 [PMID: 24365162]
  65. J Physiol Pharmacol. 2013 Dec;64(6):695-704 [PMID: 24388883]
  66. J Neuropathol Exp Neurol. 1987 Sep;46(5):567-84 [PMID: 2442313]
  67. J Neuroendocrinol. 2014 Mar;26(3):176-85 [PMID: 24528254]
  68. J Alzheimers Dis. 2014;41(1):233-41 [PMID: 24583405]
  69. Neurochem Int. 2014 May;70:1-9 [PMID: 24650723]
  70. Neurology. 2014 May 13;82(19):1724-8 [PMID: 24719484]
  71. Neurobiol Aging. 2014 Sep;35(9):2064-71 [PMID: 24726470]
  72. J Neurosci. 2014 May 14;34(20):7027-42 [PMID: 24828655]
  73. BMB Rep. 2014 Jul;47(7):369-75 [PMID: 24856828]
  74. Psychopharmacology (Berl). 2014 Jul;231(14):2725-40 [PMID: 24947976]
  75. Nat Rev Endocrinol. 2014 Sep;10(9):540-52 [PMID: 24958311]
  76. Dement Geriatr Cogn Disord. 2014;38(3-4):245-53 [PMID: 24969517]
  77. J Neurosci. 2014 Jul 2;34(27):9096-106 [PMID: 24990930]
  78. Can J Physiol Pharmacol. 2014 Aug;92(8):621-30 [PMID: 25026432]
  79. Sheng Li Ke Xue Jin Zhan. 2014 Apr;45(2):140-4 [PMID: 25069313]
  80. Neurobiol Dis. 2014 Dec;72 Pt A:72-83 [PMID: 25173805]
  81. JAMA Neurol. 2014 Dec;71(12):1478-80 [PMID: 25317720]
  82. Nat Rev Neurol. 2014 Dec;10(12):672 [PMID: 25348006]
  83. Cereb Cortex. 2016 Mar;26(3):977-90 [PMID: 25405940]
  84. J Exp Med. 2014 Dec 15;211(13):2487-96 [PMID: 25422493]
  85. Neuropeptides. 2015 Apr;50:9-16 [PMID: 25817882]
  86. Neuropharmacology. 2015 Aug;95:252-60 [PMID: 25842242]
  87. Mol Neurobiol. 2016 Jul;53(5):3168-3178 [PMID: 26033219]
  88. Sci Rep. 2015 Jun 19;5:11452 [PMID: 26090621]
  89. Peptides. 2015 Sep;71:84-93 [PMID: 26188171]
  90. Sci Rep. 2015 Jul 30;5:12584 [PMID: 26223541]
  91. Neurosci Lett. 2015 Nov 16;609:58-62 [PMID: 26453765]
  92. J Biol Chem. 2016 Jan 22;291(4):1905-20 [PMID: 26620558]
  93. Ann Med. 1989;21(2):133-6 [PMID: 2669845]
  94. Mol Neurobiol. 2017 Mar;54(2):1144-1155 [PMID: 26809582]
  95. Sleep. 2016 Jun 01;39(6):1253-60 [PMID: 26951396]
  96. Neurobiol Aging. 2016 Apr;40:120-126 [PMID: 26973111]
  97. Curr Alzheimer Res. 2016;13(9):964-72 [PMID: 27033058]
  98. Neurobiol Dis. 2016 Nov;95:210-24 [PMID: 27461050]
  99. J Neurosci Res. 2017 Jul;95(7):1415-1426 [PMID: 27796054]
  100. Sci Rep. 2016 Oct 31;6:36035 [PMID: 27796320]
  101. Neurosci Biobehav Rev. 2017 Feb;73:98-111 [PMID: 27993602]
  102. Curr Top Behav Neurosci. 2017;33:305-322 [PMID: 28012089]
  103. Biochem Biophys Res Commun. 1989 Oct 16;164(1):567-74 [PMID: 2803320]
  104. Front Aging Neurosci. 2017 Jan 19;8:327 [PMID: 28154533]
  105. Neurobiol Aging. 2017 May;53:59-66 [PMID: 28235679]
  106. J Neuroendocrinol. 2017 May;29(5): [PMID: 28380673]
  107. J Alzheimers Dis. 2017;58(1):253-261 [PMID: 28387679]
  108. Front Aging Neurosci. 2017 Jun 12;9:180 [PMID: 28659785]
  109. J Neurol. 2017 Nov;264(11):2215-2223 [PMID: 28900724]
  110. Toxicol Mech Methods. 2018 Jun;28(5):328-334 [PMID: 29185389]
  111. J Alzheimers Dis. 2018;61(2):545-552 [PMID: 29226871]
  112. Physiol Res. 2018 May 4;67(2):339-346 [PMID: 29303606]
  113. Eur J Cell Biol. 2018 Jun;97(5):339-348 [PMID: 29650257]
  114. Ann Neurol. 1985 Apr;17(4):324-8 [PMID: 4004152]
  115. Clin Neuropathol. 1983;2(2):47-54 [PMID: 6189657]
  116. J Neurol Sci. 1983 Dec;62(1-3):159-70 [PMID: 6199464]
  117. J Neurol Sci. 1983 Jan;58(1):117-22 [PMID: 6405015]
  118. J Gerontol A Biol Sci Med Sci. 1995 Sep;50(5):B315-9 [PMID: 7545530]
  119. Neuroscience. 1994 Jul;61(1):73-9 [PMID: 7969897]
  120. Brain Res. 1993 Oct 15;625(1):125-38 [PMID: 8242391]
  121. Cereb Cortex. 1996 Jul-Aug;6(4):551-60 [PMID: 8670681]
  122. Acta Neuropathol. 1997 Feb;93(2):146-53 [PMID: 9039461]
  123. Brain Res Mol Brain Res. 1997 Aug;48(1):23-9 [PMID: 9379845]
Journal Article Review
Article has an altmetric score of 6

Word Cloud

Created with Highcharts 10.0.0Alzheimer'sdiseaseneuropeptidesneuropeptideneuronalAβghrelinneurotensinpituitaryadenylatecyclase-activatingpolypeptideYsubstancePorexinincreasingADage-relatedneurodegenerativedisordercharacterizedcognitivedeficitslossDepositionbeta-amyloidpeptidecausesneurotoxicityformationplaquesbrainsNumerousstudiesindicatedincludingPACAPcloselyrelatedpathophysiologylevelsreceptorschangeexertneuroprotectiverolesmainlypreventingaccumulationglucosetransportproductionneurotrophinsinhibitingendoplasmicreticulumstressautophagymodulatingpotassiumchannelactivityhippocampallong-termpotentiationThereforemayfunctionpotentialdrugtargetspreventioncureNeuropeptidesExertNeuroprotectiveEffectsDisease

Similar Articles

Cited By