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Molecules (Basel, Switzerland)
Jan 27, 2019;24 (3):

Metabolism and Biological Activities of 4-Methyl-Sterols.

Sylvain Darnet, Hubert Schaller
Author Information
  1. Sylvain Darnet: CVACBA, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, PA 66075-750, Brazil. sylvain@ufpa.br. ORCID
  2. Hubert Schaller: Plant Isoprenoid Biology (PIB) team, Institut de Biologie Moléculaire des Plantes du CNRS, Université de Strasbourg, Strasbourg 67084, France. hubert.schaller@ibmp-cnrs.unistra.fr. ORCID
PMID: 30691248 DOI: 10.3390/molecules24030451

Abstract

4,4-Dimethylsterols and 4-methylsterols are sterol biosynthetic intermediates (C4-SBIs) acting as precursors of cholesterol, ergosterol, and phytosterols. Their accumulation caused by genetic lesions or biochemical inhibition causes severe cellular and developmental phenotypes in all organisms. Functional evidence supports their role as meiosis activators or as signaling molecules in mammals or plants. Oxygenated C4-SBIs like 4-carboxysterols act in major biological processes like auxin signaling in plants and immune system development in mammals. It is the purpose of this article to point out important milestones and significant advances in the understanding of the biogenesis and biological activities of C4-SBIs.

Keywords

4-methylsterol C4-demethylation complex (C4DMC) development genetic disease hormone steroid sterol

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Grants

  1. LIA1170/Centre National de la Recherche Scientifique

MeSH Term

Animals
Gene Expression Regulation
Humans
Lipid Metabolism
Mammals
Methylation
Plants
Saccharomyces cerevisiae
Species Specificity
Sterols
Structure-Activity Relationship

Chemicals

Sterols
Journal Article Review
Article has an altmetric score of 1

Word Cloud

Created with Highcharts 10.0.0C4-SBIssterolgeneticsignalingmammalsplantslikebiologicaldevelopment44-Dimethylsterols4-methylsterolsbiosyntheticintermediatesactingprecursorscholesterolergosterolphytosterolsaccumulationcausedlesionsbiochemicalinhibitioncausesseverecellulardevelopmentalphenotypesorganismsFunctionalevidencesupportsrolemeiosisactivatorsmoleculesOxygenated4-carboxysterolsactmajorprocessesauxinimmunesystempurposearticlepointimportantmilestonessignificantadvancesunderstandingbiogenesisactivitiesMetabolismBiologicalActivities4-Methyl-Sterols4-methylsterolC4-demethylationcomplexC4DMCdiseasehormonesteroid

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