Pentadecanal inspired molecules as new anti-biofilm agents against Staphylococcus epidermidis.
Annarita Ricciardelli, Angela Casillo, Rosanna Papa, Daria Maria Monti, Paola Imbimbo, Gianluca Vrenna, Marco Artini, Laura Selan, Maria Michela Corsaro, Maria Luisa Tutino, Ermenegilda Parrilli
Author Information
Annarita Ricciardelli: a Chemical Sciences , University of Naples "Federico II" , Naples , Italy.
Angela Casillo: a Chemical Sciences , University of Naples "Federico II" , Naples , Italy.
Rosanna Papa: b Department of Public Health and Infectious Diseases , Sapienza University , Rome , Italy.
Daria Maria Monti: a Chemical Sciences , University of Naples "Federico II" , Naples , Italy.
Paola Imbimbo: a Chemical Sciences , University of Naples "Federico II" , Naples , Italy.
Gianluca Vrenna: b Department of Public Health and Infectious Diseases , Sapienza University , Rome , Italy.
Marco Artini: b Department of Public Health and Infectious Diseases , Sapienza University , Rome , Italy.
Laura Selan: b Department of Public Health and Infectious Diseases , Sapienza University , Rome , Italy.
Maria Michela Corsaro: a Chemical Sciences , University of Naples "Federico II" , Naples , Italy.
Maria Luisa Tutino: a Chemical Sciences , University of Naples "Federico II" , Naples , Italy.
Ermenegilda Parrilli: a Chemical Sciences , University of Naples "Federico II" , Naples , Italy.
Staphylococcus epidermidis, a harmless human skin colonizer, is a significant nosocomial pathogen in predisposed hosts because of its capability to form a biofilm on indwelling medical devices. In a recent paper, the purification and identification of the Pentadecanal produced by the Antarctic bacterium Pseudoalteromonas haloplanktis TAC125, able to impair S. epidermidisbiofilm formation, were reported. Here the authors report on the chemical synthesis of Pentadecanal derivatives, their anti-biofilm activity on S. epidermidis, and their action in combination with antibiotics. The results clearly indicate that the Pentadecanal derivatives were able to prevent, to a different extent, biofilm formation and that pentadecanoic acid positively modulated the antimicrobial activity of the vancomycin. The cytotoxicity of these new anti-biofilm molecules was tested on two different immortalized eukaryotic cell lines in view of their potential applications.
