Room Temperature Deoxyfluorination of Benzaldehydes and α-Ketoesters with Sulfuryl Fluoride and Tetramethylammonium Fluoride.
Patrick R Melvin, Devin M Ferguson, Sydonie D Schimler, Douglas C Bland, Melanie S Sanford
Author Information
Patrick R Melvin: Department of Chemistry , University of Michigan , 930 North University Avenue , Ann Arbor , Michigan 48109 , United States.
Devin M Ferguson: Department of Chemistry , University of Michigan , 930 North University Avenue , Ann Arbor , Michigan 48109 , United States.
Sydonie D Schimler: Department of Chemistry , University of Michigan , 930 North University Avenue , Ann Arbor , Michigan 48109 , United States. ORCID
Douglas C Bland: CP PD&P Process Chemistry, Corteva Agriscience , Agriculture Division of DowDuPont , 9330 Zionsville Road , Indianapolis , Indiana 46268 , United States.
Melanie S Sanford: Department of Chemistry , University of Michigan , 930 North University Avenue , Ann Arbor , Michigan 48109 , United States. ORCID
A method for the room temperature deoxyfluorination of benzaldehydes and α-ketoesters using sulfuryl fluoride and MeNF is described. A large scope of aryl and heteroaryl substrates is demonstrated, and this method compares favorably to other common deoxyfluorination methods for many substrates.
