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The American journal of tropical medicine and hygiene
05, 2019;100 (5): 1164-1169.

Indigenous Infection in an Endemic Population at the Thai-Myanmar Border.

Ritthideach Yorsaeng, Teerawat Saeseu, Kesinee Chotivanich, Ingrid Felger, Rahel Wampfler, Liwang Cui, Ivo Mueller, Jetsumon Sattabongkot, Wang Nguitragool
Author Information
  1. Ritthideach Yorsaeng: Mahidol Vivax Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
  2. Teerawat Saeseu: Mahidol Vivax Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
  3. Kesinee Chotivanich: Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
  4. Ingrid Felger: University of Basel, Basel, Switzerland.
  5. Rahel Wampfler: University of Basel, Basel, Switzerland.
  6. Liwang Cui: Department of Entomology, Pennsylvania State University, University Park, Pennsylvania.
  7. Ivo Mueller: Malaria: Parasites and Hosts Unit, Department of Parasites and Insect Vectors, Institut Pasteur, Paris, France.
  8. Jetsumon Sattabongkot: Mahidol Vivax Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
  9. Wang Nguitragool: Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
PMID: 30793693 DOI: 10.4269/ajtmh.18-0597

Abstract

is a neglected malaria parasite. It has wide geographic distribution and, although often associated with mild malaria, is linked to a high burden of anemia and nephrotic syndromes. Here, we report a cohort study conducted in the Kanchanaburi Province of Thailand during May 2013-June 2014 in which infection was detected. Of the 812 study participants, two were found to be infected with . One had an infection that led to acute malaria, but the other was positive for at multiple visits during the study and apparently had chronic asymptomatic infection. Such persistent infection may explain how has been able to thrive at very low prevalence and represents a challenge for malaria elimination.

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Grants

  1. /Wellcome Trust
  2. D43 TW006571/FIC NIH HHS
  3. U19 AI089672/NIAID NIH HHS
  4. 101073/Z/13Z/Wellcome Trust

MeSH Term

Adult
Asymptomatic Infections
Cohort Studies
Endemic Diseases
Female
Geography
Humans
Indigenous Peoples
Malaria
Male
Middle Aged
Myanmar
Plasmodium malariae
Prevalence
Thailand
Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Word Cloud

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