Septic patients in the intensive care unit present different nasal microbiotas.
Xi-Lan Tan, Hai-Yue Liu, Jun Long, Zhaofang Jiang, Yuemei Luo, Xin Zhao, Shumin Cai, Xiaozhu Zhong, Zhongran Cen, Jin Su, Hongwei Zhou
Author Information
Xi-Lan Tan: Department of Environmental Health, School of Public Health, Southern Medical University, Guangzhou, PR China.
Hai-Yue Liu: State Key Laboratory of Organ Failure Research, Division of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, PR China.
Jun Long: State Key Laboratory of Organ Failure Research, Division of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, PR China.
Zhaofang Jiang: State Key Laboratory of Organ Failure Research, Division of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, PR China.
Yuemei Luo: Department of Environmental Health, School of Public Health, Southern Medical University, Guangzhou, PR China.
Xin Zhao: State Key Laboratory of Organ Failure Research, Division of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, PR China.
Shumin Cai: Department of Intensive Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, PR China.
Xiaozhu Zhong: Division of Infection Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, PR China.
Zhongran Cen: Division of Intensive Care Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, PR China.
Jin Su: Chronic Airways Diseases Laboratory, Department of Respiratory & Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, PR China.
Hongwei Zhou: Department of Environmental Health, School of Public Health, Southern Medical University, Guangzhou, PR China.
AIM: The primary objective of this study was to evaluate correlations among mortality, intensive care unit (ICU) length of stay and airway microbiotas in septic patients. MATERIALS & METHODS: A deep-sequencing analysis of the 16S rRNA gene V4 region was performed. RESULTS: The nasal microbiota in septic patients was dominated by three nasal bacterial types (Corynebacterium, Staphylococcus and Acinetobacter). The Acinetobacter type was associated with the lowest diversity and longest length of stay (median: 9 days), and the Corynebacterium type was associated with the shortest length of stay. We found that the Acinetobacter type in the >9-day group was associated with the highest mortality (33%). CONCLUSION: Septic patients have three nasal microbiota types, and the nasal microbiota is related to the length of stay and mortality.
