A Hierarchical Taxonomy of Psychopathology Can Transform Mental Health Research.

Christopher C Conway, Miriam K Forbes, Kelsie T Forbush, Eiko I Fried, Michael N Hallquist, Roman Kotov, Stephanie N Mullins-Sweatt, Alexander J Shackman, Andrew E Skodol, Susan C South, Matthew Sunderland, Monika A Waszczuk, David H Zald, Mohammad H Afzali, Marina A Bornovalova, Natacha Carragher, Anna R Docherty, Katherine G Jonas, Robert F Krueger, Praveetha Patalay, Aaron L Pincus, Jennifer L Tackett, Ulrich Reininghaus, Irwin D Waldman, Aidan G C Wright, Johannes Zimmermann, Bo Bach, R Michael Bagby, Michael Chmielewski, David C Cicero, Lee Anna Clark, Tim Dalgleish, Colin G DeYoung, Christopher J Hopwood, Masha Y Ivanova, Robert D Latzman, Christopher J Patrick, Camilo J Ruggero, Douglas B Samuel, David Watson, Nicholas R Eaton
Author Information
  1. Christopher C Conway: 1 Department of Psychological Sciences, College of William & Mary. ORCID
  2. Miriam K Forbes: 2 Centre for Emotional Health, Department of Psychology, Macquarie University.
  3. Kelsie T Forbush: 3 Department of Psychology, University of Kansas.
  4. Eiko I Fried: 4 Department of Psychology, University of Amsterdam. ORCID
  5. Michael N Hallquist: 5 Department of Psychology, Pennsylvania State University.
  6. Roman Kotov: 6 Department of Psychiatry, State University of New York.
  7. Stephanie N Mullins-Sweatt: 7 Department of Psychology, Oklahoma State University.
  8. Alexander J Shackman: 8 Department of Psychology and Neuroscience and Cognitive Science Program, University of Maryland.
  9. Andrew E Skodol: 9 Department of Psychiatry, University of Arizona.
  10. Susan C South: 10 Department of Psychological Sciences, Purdue University.
  11. Matthew Sunderland: 11 National Health and Medical Research Council Centre for Research Excellence in Mental Health and Substance Use, National Drug and Alcohol Research Centre, University of New South Wales.
  12. Monika A Waszczuk: 6 Department of Psychiatry, State University of New York.
  13. David H Zald: 12 Department of Psychology, Vanderbilt University.
  14. Mohammad H Afzali: 13 Department of Psychiatry, University of Montreal.
  15. Marina A Bornovalova: 14 Department of Psychology, University of South Florida.
  16. Natacha Carragher: 15 Medical Education and Student Office, Faculty of Medicine, University of New South Wales.
  17. Anna R Docherty: 16 Department of Psychiatry, University of Utah.
  18. Katherine G Jonas: 6 Department of Psychiatry, State University of New York.
  19. Robert F Krueger: 17 Department of Psychology, University of Minnesota.
  20. Praveetha Patalay: 18 Institute of Psychology, Health and Society, University of Liverpool.
  21. Aaron L Pincus: 5 Department of Psychology, Pennsylvania State University.
  22. Jennifer L Tackett: 19 Department of Psychology, Northwestern University.
  23. Ulrich Reininghaus: 20 Department of Psychiatry and Psychology, Maastricht University.
  24. Irwin D Waldman: 22 Department of Psychology, Emory University.
  25. Aidan G C Wright: 23 Department of Psychology, University of Pittsburgh.
  26. Johannes Zimmermann: 24 Department of Psychology, University of Kassel.
  27. Bo Bach: 25 Psychiatric Research Unit, Slagelse Psychiatric Hospital.
  28. R Michael Bagby: 26 Departments of Psychology and Psychiatry, University of Toronto.
  29. Michael Chmielewski: 27 Department of Psychology, Southern Methodist University.
  30. David C Cicero: 28 Department of Psychology, University of Hawaii at Manoa.
  31. Lee Anna Clark: 29 Department of Psychology, University of Notre Dame.
  32. Tim Dalgleish: 30 Medical Research Council Cognition and Brain Sciences Unit, Cambridge, United Kingdom.
  33. Colin G DeYoung: 17 Department of Psychology, University of Minnesota.
  34. Christopher J Hopwood: 31 Department of Psychology, University of California, Davis.
  35. Masha Y Ivanova: 32 Department of Psychiatry, University of Vermont.
  36. Robert D Latzman: 33 Department of Psychology, Georgia State University. ORCID
  37. Christopher J Patrick: 34 Department of Psychology, Florida State University.
  38. Camilo J Ruggero: 35 Department of Psychology, University of North Texas.
  39. Douglas B Samuel: 10 Department of Psychological Sciences, Purdue University.
  40. David Watson: 29 Department of Psychology, University of Notre Dame.
  41. Nicholas R Eaton: 36 Department of Psychology, Stony Brook University.

Abstract

For more than a century, research on psychopathology has focused on categorical diagnoses. Although this work has produced major discoveries, growing evidence points to the superiority of a dimensional approach to the science of mental illness. Here we outline one such dimensional system-the Hierarchical Taxonomy of Psychopathology (HiTOP)-that is based on empirical patterns of co-occurrence among psychological symptoms. We highlight key ways in which this framework can advance mental-health research, and we provide some heuristics for using HiTOP to test theories of psychopathology. We then review emerging evidence that supports the value of a hierarchical, dimensional model of mental illness across diverse research areas in psychological science. These new data suggest that the HiTOP system has the potential to accelerate and improve research on mental-health problems as well as efforts to more effectively assess, prevent, and treat mental illness.

Keywords

References

  1. Psychol Assess. 2009 Sep;21(3):256-71 [PMID: 19719339]
  2. Mol Psychiatry. 2016 May;21(5):717-21 [PMID: 26303662]
  3. Psychol Bull. 2017 Feb;143(2):142-186 [PMID: 28004947]
  4. Mol Psychiatry. 2019 Mar;24(3):409-420 [PMID: 29317742]
  5. Am J Psychiatry. 2018 Sep 1;175(9):831-844 [PMID: 29621902]
  6. Transl Psychiatry. 2018 Oct 2;8(1):205 [PMID: 30279410]
  7. Psychol Med. 2010 Feb;40(2):273-88 [PMID: 19515267]
  8. Transl Psychiatry. 2017 Nov 30;7(11):1264 [PMID: 29187730]
  9. Br J Psychiatry. 2012 Feb;200(2):107-15 [PMID: 22157798]
  10. J Abnorm Psychol. 2013 Feb;122(1):86-92 [PMID: 22905862]
  11. Psychol Rev. 1993 Oct;100(4):674-701 [PMID: 8255953]
  12. Psychophysiology. 2006 Jan;43(1):84-92 [PMID: 16629688]
  13. J Child Psychol Psychiatry. 2018 Jun;59(6):667-675 [PMID: 29197107]
  14. Arch Gen Psychiatry. 2010 Feb;67(2):113-23 [PMID: 20124111]
  15. Monogr Soc Res Child Dev. 1991;56(3):1-131 [PMID: 1770964]
  16. Psychol Rev. 2016 Jan;123(1):90-6 [PMID: 26214685]
  17. J Psychiatr Res. 2004 Jan;38(1):17-25 [PMID: 14690767]
  18. Mol Psychiatry. 2018 Oct;23(10):1981-1989 [PMID: 28924181]
  19. JAMA Psychiatry. 2015 Nov;72(11):1135-42 [PMID: 26465073]
  20. Lancet. 2016 Oct 8;388(10053):1545-1602 [PMID: 27733282]
  21. J Abnorm Psychol. 2016 Nov;125(8):1120-1134 [PMID: 27819472]
  22. J Abnorm Child Psychol. 2018 Oct;46(7):1373-1383 [PMID: 29359267]
  23. Dev Psychopathol. 2016 Nov;28(4pt1):971-986 [PMID: 27739384]
  24. Psychol Rev. 2003 Apr;110(2):203-219 [PMID: 12747522]
  25. J Abnorm Psychol. 2017 May;126(4):454-477 [PMID: 28333488]
  26. Am J Psychiatry. 2016 May 1;173(5):517-26 [PMID: 26806874]
  27. Perspect Psychol Sci. 2017 Nov;12(6):999-1020 [PMID: 28873325]
  28. J Affect Disord. 2015 Jan 15;171:6-12 [PMID: 25282144]
  29. JAMA Psychiatry. 2015 Apr;72(4):305-15 [PMID: 25651064]
  30. Curr Opin Psychiatry. 2011 Jul;24(4):307-12 [PMID: 21602684]
  31. Soc Psychiatry Psychiatr Epidemiol. 2013 Sep;48(9):1367-75 [PMID: 23306423]
  32. Clin Psychol Rev. 2010 Jul;30(5):582-93 [PMID: 20478648]
  33. Psychol Bull. 2011 Sep;137(5):856-79 [PMID: 21574681]
  34. J Physiol Paris. 2015 Feb-Jun;109(1-3):3-15 [PMID: 24787485]
  35. J Consult Clin Psychol. 2011 Apr;79(2):159-70 [PMID: 21341888]
  36. Clin Psychol Sci. 2017 Nov;5(6):1001-1013 [PMID: 29399423]
  37. Am J Psychiatry. 2017 Jul 1;174(7):657-666 [PMID: 28135847]
  38. J Abnorm Psychol. 2012 Aug;121(3):754-66 [PMID: 22428789]
  39. Nat Rev Neurosci. 2007 Sep;8(9):725-32 [PMID: 17704814]
  40. Clin Psychol Sci. 2014 Mar;2(2):119-137 [PMID: 25360393]
  41. J Child Psychol Psychiatry. 2015 Apr;56(4):415-22 [PMID: 25052460]
  42. Am J Psychiatry. 2018 Jan 1;175(1):54-62 [PMID: 28817944]
  43. J Child Psychol Psychiatry. 2018 Aug;59(8):855-862 [PMID: 29315560]
  44. Psychol Med. 2015 Jun;45(8):1687-98 [PMID: 25499142]
  45. Psychol Methods. 2005 Jun;10(2):178-92 [PMID: 15998176]
  46. Dev Psychopathol. 2015 Nov;27(4 Pt 1):1295-312 [PMID: 26439075]
  47. World Psychiatry. 2018 Oct;17(3):282-293 [PMID: 30229571]
  48. Am J Psychiatry. 2013 Jan;170(1):59-70 [PMID: 23111466]
  49. JAMA Psychiatry. 2017 Sep 1;74(9):875-884 [PMID: 28768327]
  50. BMC Med. 2013 May 14;11:126 [PMID: 23672542]
  51. Compr Psychiatry. 2017 Nov;79:40-52 [PMID: 28755757]
  52. Dev Cogn Neurosci. 2017 Oct;27:58-68 [PMID: 28818707]
  53. J Anxiety Disord. 2016 Mar;38:102-9 [PMID: 26874292]
  54. Hum Brain Mapp. 2017 Apr;38(4):1846-1864 [PMID: 28067006]
  55. Compr Psychiatry. 2017 Nov;79:80-88 [PMID: 28495012]
  56. Int J Psychophysiol. 2003 May;48(2):147-78 [PMID: 12763572]
  57. JAMA Psychiatry. 2015 Jul;72(7):706-13 [PMID: 25901783]
  58. J Clin Child Adolesc Psychol. 2016;45(3):361-82 [PMID: 26849071]
  59. Psychol Sci Public Interest. 2017 Sep;18(2):72-145 [PMID: 29211974]
  60. Psychol Med. 1999 May;29(3):595-606 [PMID: 10405080]
  61. Depress Anxiety. 2008;25(7):E34-46 [PMID: 18027844]
  62. Psychol Med. 2014 Feb;44(3):647-55 [PMID: 23574685]
  63. Psychol Med. 2012 Aug;42(8):1705-13 [PMID: 22132840]
  64. J Abnorm Psychol. 2020 Feb;129(2):143-161 [PMID: 31804095]
  65. J Abnorm Psychol. 2012 Nov;121(4):971-7 [PMID: 22845652]
  66. Clin Psychol Rev. 2011 Nov;31(7):1169-82 [PMID: 21855827]
  67. J Psychiatr Res. 2018 Sep;104:211-216 [PMID: 30103069]
  68. Am J Psychiatry. 2015 Dec;172(12):1215-23 [PMID: 26085042]
  69. JAMA Psychiatry. 2014 Aug;71(8):905-16 [PMID: 24920372]
  70. Psychophysiology. 2016 Mar;53(3):415-24 [PMID: 26877135]
  71. Mol Psychiatry. 2018 Apr;23(4):1084-1090 [PMID: 28397842]
  72. J Affect Disord. 2017 Jan 15;208:191-197 [PMID: 27792962]
  73. Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 May;2(4):310-317 [PMID: 28713866]
  74. JAMA Psychiatry. 2013 Jun;70(6):599-607 [PMID: 23740048]
  75. J Child Psychol Psychiatry. 2016 Jan;57(1):55-64 [PMID: 26111611]
  76. Arch Gen Psychiatry. 1998 Oct;55(10):941-8 [PMID: 9783566]
  77. Behav Genet. 2013 Sep;43(5):363-73 [PMID: 23942779]
  78. Neuron. 2014 Jun 18;82(6):1205-8 [PMID: 24945765]
  79. J Am Acad Child Adolesc Psychiatry. 2016 Dec;55(12):1038-1045.e4 [PMID: 27871638]
  80. J Abnorm Psychol. 1998 May;107(2):216-27 [PMID: 9604551]
  81. Behav Genet. 2017 May;47(3):265-277 [PMID: 28108863]
  82. Neuron. 2015 Feb 4;85(3):505-11 [PMID: 25654256]
  83. J Clin Child Adolesc Psychol. 2019 Mar-Apr;48(2):306-315 [PMID: 28541762]
  84. Am J Psychiatry. 2017 Jul 1;174(7):676-685 [PMID: 28320224]
  85. J Abnorm Psychol. 2011 Feb;120(1):198-209 [PMID: 21319931]
  86. J Abnorm Psychol. 2017 Jul;126(5):613-634 [PMID: 28471212]
  87. Psychol Med. 2011 Jul;41(7):1437-47 [PMID: 21054917]
  88. Trends Cogn Sci. 2018 May;22(5):368-369 [PMID: 29576465]
  89. J Psychiatr Res. 2015 Sep;68:337-45 [PMID: 26037889]
  90. Soc Psychiatry Psychiatr Epidemiol. 2007 Jul;42(7):554-60 [PMID: 17516015]
  91. Educ Psychol Meas. 2016 Oct;76(5):741-770 [PMID: 29795886]
  92. Psychol Monogr. 1966;80(7):1-37 [PMID: 5968338]
  93. J Abnorm Psychol. 1991 Nov;100(4):555-61 [PMID: 1757669]
  94. Depress Anxiety. 2014 Oct;31(10):834-42 [PMID: 24995938]
  95. Psychol Med. 2016 Jun;46(8):1567-79 [PMID: 26997244]
  96. Assessment. 2019 Jul;26(5):944-960 [PMID: 30043620]
  97. Mol Psychiatry. 2016 Oct;21(10):1391-9 [PMID: 26754954]
  98. Compr Psychiatry. 2017 Nov;79:89-97 [PMID: 28215792]
  99. J Abnorm Psychol. 2011 Nov;120(4):935-47 [PMID: 21942335]

Grants

  1. R21 DA040717/NIDA NIH HHS
  2. PB-PG-0214-33072/Department of Health
  3. MC_U105579215/Medical Research Council
  4. K01 MH109765/NIMH NIH HHS
  5. MC_UU_00005/4/Medical Research Council
  6. R01 MH107444/NIMH NIH HHS

MeSH Term

Heuristics
Humans
Mental Disorders
Models, Theoretical
Research Design
Terminology as Topic

Word Cloud

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