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Neural regeneration research
Aug, 2019;14 (8): 1343-1351.

Therapeutic strategies for peripheral nerve injury: decellularized nerve conduits and Schwann cell transplantation.

Gong-Hai Han, Jiang Peng, Ping Liu, Xiao Ding, Shuai Wei, Sheng Lu, Yu Wang
Author Information
  1. Gong-Hai Han: Kunming Medical University, Kunming, Yunnan Province; Institute of Orthopedics, Chinese PLA General Hospital, Beijing, China.
  2. Jiang Peng: Institute of Orthopedics, Chinese PLA General Hospital, Beijing, China.
  3. Ping Liu: Shanxi Medical University, Taiyuan, Shanxi Province, China.
  4. Xiao Ding: Shihezi University Medical College, Shihezi, Xinjiang Uygur Autonomous Region, China.
  5. Shuai Wei: Shihezi University Medical College, Shihezi, Xinjiang Uygur Autonomous Region, China.
  6. Sheng Lu: 920th Hospital of Joint Service Support Force, Kunming, Yunnan Province, China.
  7. Yu Wang: Institute of Orthopedics, Chinese PLA General Hospital, Beijing, China.
PMID: 30964052 DOI: 10.4103/1673-5374.253511

Abstract

In recent years, the use of Schwann cell transplantation to repair peripheral nerve injury has attracted much attention. Animal-based studies show that the transplantation of Schwann cells in combination with nerve scaffolds promotes the repair of injured peripheral nerves. Autologous Schwann cell transplantation in humans has been reported recently. This article reviews current methods for removing the extracellular matrix and analyzes its composition and function. The development and secretory products of Schwann cells are also reviewed. The methods for the repair of peripheral nerve injuries that use myelin and Schwann cell transplantation are assessed. This survey of the literature data shows that using a decellularized nerve conduit combined with Schwann cells represents an effective strategy for the treatment of peripheral nerve injury. This analysis provides a comprehensive basis on which to make clinical decisions for the repair of peripheral nerve injury.

Keywords

Schwann cell decellularization extracellular matrix nerve conduits nerve regeneration neural regeneration peripheral nerve injury

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Created with Highcharts 10.0.0nerveSchwannperipheralcelltransplantationrepairinjurycellsusemethodsextracellularmatrixdecellularizedconduitsregenerationrecentyearsattractedmuchattentionAnimal-basedstudiesshowcombinationscaffoldspromotesinjurednervesAutologoushumansreportedrecentlyarticlereviewscurrentremovinganalyzescompositionfunctiondevelopmentsecretoryproductsalsoreviewedinjuriesmyelinassessedsurveyliteraturedatashowsusingconduitcombinedrepresentseffectivestrategytreatmentanalysisprovidescomprehensivebasismakeclinicaldecisionsTherapeuticstrategiesinjury:decellularizationneural

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