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Journal of ginseng research
Apr, 2019;43 (2): 163-171.

Emerging signals modulating potential of ginseng and its active compounds focusing on neurodegenerative diseases.

Md Jakaria, Joonsoo Kim, Govindarajan Karthivashan, Shin-Young Park, Palanivel Ganesan, Dong-Kug Choi
Author Information
  1. Md Jakaria: Department of Applied Life Science, Graduate School, Konkuk University, Chungju, Republic of Korea.
  2. Joonsoo Kim: Department of Applied Life Science, Graduate School, Konkuk University, Chungju, Republic of Korea.
  3. Govindarajan Karthivashan: Research Institute of Inflammatory Disease, and Department of Biotechnology, College of Biomedical and Health Science, Konkuk University, Chungju 27478, Korea.
  4. Shin-Young Park: Department of Applied Life Science, Graduate School, Konkuk University, Chungju, Republic of Korea.
  5. Palanivel Ganesan: Research Institute of Inflammatory Disease, and Department of Biotechnology, College of Biomedical and Health Science, Konkuk University, Chungju 27478, Korea.
  6. Dong-Kug Choi: Department of Applied Life Science, Graduate School, Konkuk University, Chungju, Republic of Korea.
PMID: 30976157 DOI: 10.1016/j.jgr.2018.01.001

Abstract

Common features of neurodegenerative diseases (NDDs) include progressive dysfunctions and neuronal injuries leading to deterioration in normal brain functions. At present, ginseng is one of the most frequently used natural products. Its use has a long history as a cure for various diseases because its extracts and active compounds exhibit several pharmacological properties against several disorders. However, the pathophysiology of NDDs is not fully clear, but researchers have found that various ion channels and specific signaling pathways might have contributed to the disease pathogenesis. Apart from the different pharmacological potentials, ginseng and its active compounds modulate various ion channels and specific molecular signaling pathways related to the nervous system. Here, we discuss the signal modulating potential of ginseng and its active compounds mainly focusing on those relevant to NDDs.

Keywords

Active compounds Ginseng Ion channels Neurodegenerative diseases Signaling pathway

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