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04 11, 2019;10 (4):

A Systematically Assembled Signature of Genes to be Deep-Sequenced for Their Associations with the Blood Pressure Response to Exercise.

Linda S Pescatello, Paul Parducci, Jill Livingston, Beth A Taylor
Author Information
  1. Linda S Pescatello: Department of Kinesiology, University of Connecticut, Storrs, CT 06269, USA. Linda.Pescatello@uconn.edu.
  2. Paul Parducci: Department of Kinesiology, University of Connecticut, Storrs, CT 06269, USA. Paul.Parducci@uconn.edu.
  3. Jill Livingston: Homer Babbidge Library, Health Sciences, University of Connecticut, Storrs, CT 06269, USA. Jill.Livingston@uconn.edu.
  4. Beth A Taylor: Department of Kinesiology, University of Connecticut, Storrs, CT 06269, USA. Beth.Taylor@uconn.edu.
PMID: 30979034 DOI: 10.3390/genes10040295

Abstract

Exercise is one of the best nonpharmacologic therapies to treat hypertension. The blood pressure (BP) response to exercise is heritable. Yet, the genetic basis for the antihypertensive effects of exercise remains elusive. To assemble a prioritized gene signature, we performed a systematic review with a series of Boolean searches in PubMed (including Medline) from earliest coverage. The inclusion criteria were human genes in major BP regulatory pathways reported to be associated with: (1) the BP response to exercise; (2) hypertension in genome-wide association studies (GWAS); (3) the BP response to pharmacotherapy; (4a) physical activity and/or obesity in GWAS; and (4b) BP, physical activity, and/or obesity in non-GWAS. Included GWAS reports disclosed the statistically significant thresholds used for multiple testing. The search yielded 1422 reports. Of these, 57 trials qualified from which we extracted 11 genes under criteria 1, 18 genes under criteria 2, 28 genes under criteria 3, 27 genes under criteria 4a, and 29 genes under criteria 4b. We also included 41 genes identified from our previous work. Deep-sequencing the exons of this systematically assembled signature of genes represents a cost and time efficient approach to investigate the genomic basis for the antihypertensive effects of exercise.

Keywords

antihypertensive therapy healthy lifestyle physical exercise

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MeSH Term

Antihypertensive Agents
Blood Pressure
Exercise
Exons
Genome-Wide Association Study
High-Throughput Nucleotide Sequencing
Humans
Hypertension

Chemicals

Antihypertensive Agents
Journal Article Research Support, Non-U.S. Gov't Review
Article has an altmetric score of 3

Word Cloud

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