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09, 2019;10 (9): 688-693.

Propofol reduces synaptic strength by inhibiting sodium and calcium channels at nerve terminals.

Qing-Zhuo Liu, Mei Hao, Zi-Yang Zhou, Jian-Long Ge, Yi-Chen Wu, Ling-Ling Zhao, Xiang Wu, Yi Feng, Hong Gao, Shun Li, Lei Xue
Author Information
  1. Qing-Zhuo Liu: State Key Laboratory of Medical Neurobiology, Department of Physiology and Biophysics, School of Life Sciences and Collaborative Innovation Centre for Brain Science, Fudan University, Shanghai, 200438, China.
  2. Mei Hao: State Key Laboratory of Medical Neurobiology, Department of Physiology and Biophysics, School of Life Sciences and Collaborative Innovation Centre for Brain Science, Fudan University, Shanghai, 200438, China.
  3. Zi-Yang Zhou: State Key Laboratory of Medical Neurobiology, Department of Physiology and Biophysics, School of Life Sciences and Collaborative Innovation Centre for Brain Science, Fudan University, Shanghai, 200438, China.
  4. Jian-Long Ge: State Key Laboratory of Medical Neurobiology, Department of Physiology and Biophysics, School of Life Sciences and Collaborative Innovation Centre for Brain Science, Fudan University, Shanghai, 200438, China.
  5. Yi-Chen Wu: State Key Laboratory of Medical Neurobiology, Department of Physiology and Biophysics, School of Life Sciences and Collaborative Innovation Centre for Brain Science, Fudan University, Shanghai, 200438, China.
  6. Ling-Ling Zhao: State Key Laboratory of Medical Neurobiology, Department of Physiology and Biophysics, School of Life Sciences and Collaborative Innovation Centre for Brain Science, Fudan University, Shanghai, 200438, China.
  7. Xiang Wu: The Affiliated Hospital of Medical College, Ningbo University, Ningbo, 315020, China.
  8. Yi Feng: Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, 200080, China.
  9. Hong Gao: Department of Orthopaedic Surgery, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
  10. Shun Li: Zhejiang Provincial People's Hospital, Hangzhou, 310000, China. 1148449287@qq.com.
  11. Lei Xue: State Key Laboratory of Medical Neurobiology, Department of Physiology and Biophysics, School of Life Sciences and Collaborative Innovation Centre for Brain Science, Fudan University, Shanghai, 200438, China. lxue@fudan.edu.cn. ORCID
PMID: 31028590 DOI: 10.1007/s13238-019-0624-1

Abstract

No abstract text available.

References

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MeSH Term

Anesthetics, Intravenous
Animals
Brain Stem
Calcium
Calcium Channel Blockers
Excitatory Postsynaptic Potentials
Presynaptic Terminals
Propofol
Rats
Sodium
Sodium Channel Blockers

Chemicals

Anesthetics, Intravenous
Calcium Channel Blockers
Sodium Channel Blockers
Sodium
Calcium
Propofol
Letter Research Support, Non-U.S. Gov't
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Created with Highcharts 10.0.0Propofolreducessynapticstrengthinhibitingsodiumcalciumchannelsnerveterminals

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