Pharmacodynamics of Omadacycline against Staphylococcus aureus in the Neutropenic Murine Thigh Infection Model.
Alexander J Lepak, Miao Zhao, Karen Marchillo, Jamie VanHecker, David R Andes
Author Information
Alexander J Lepak: Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Miao Zhao: Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Karen Marchillo: William S. Middleton Memorial VA Hospital, Madison, Wisconsin, USA.
Jamie VanHecker: William S. Middleton Memorial VA Hospital, Madison, Wisconsin, USA.
David R Andes: Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA dra@medicine.wisc.edu.
Omadacycline is a novel aminomethylcycline antibiotic with potent activity against , including methicillin-susceptible (MSSA) and methicillin-resistant (MRSA). We investigated the pharmacodynamic activity of omadacycline against 10 MSSA/MRSA strains in a neutropenic murine thigh model. The median 24-h area under the concentration-time curve (AUC)/MIC values associated with net stasis and 1-log kill were 21.9 and 57.7, respectively.
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Animals
Anti-Bacterial Agents
Disease Models, Animal
Methicillin-Resistant Staphylococcus aureus
Mice
Microbial Sensitivity Tests
Neutropenia
Staphylococcal Infections
Tetracyclines
Thigh
Anti-Bacterial Agents
Tetracyclines
omadacycline
