Antibacterial activity of cinnamon essential oils and their synergistic potential with antibiotics.
Yassine El Atki, Imane Aouam, Fatima El Kamari, Amal Taroq, Kaotar Nayme, Mohammed Timinouni, Badiaa Lyoussi, Abdelfattah Abdellaoui
Author Information
Yassine El Atki: Department of Biology, Laboratory of Physiology Pharmacology and Environmental Health, Faculty of Sciences Dhar Mehraz, Sidi Mohamed Ben Abdellah University, Fez, Morocco.
Imane Aouam: Department of Biology, Laboratory of Physiology Pharmacology and Environmental Health, Faculty of Sciences Dhar Mehraz, Sidi Mohamed Ben Abdellah University, Fez, Morocco.
Fatima El Kamari: Department of Biology, Laboratory of Physiology Pharmacology and Environmental Health, Faculty of Sciences Dhar Mehraz, Sidi Mohamed Ben Abdellah University, Fez, Morocco.
Amal Taroq: Department of Biology, Laboratory of Physiology Pharmacology and Environmental Health, Faculty of Sciences Dhar Mehraz, Sidi Mohamed Ben Abdellah University, Fez, Morocco.
Kaotar Nayme: Molecular Bacteriology Laboratory, Pasteur Institute of Morocco, Casablanca, Morocco.
Mohammed Timinouni: Molecular Bacteriology Laboratory, Pasteur Institute of Morocco, Casablanca, Morocco.
Badiaa Lyoussi: Department of Biology, Laboratory of Physiology Pharmacology and Environmental Health, Faculty of Sciences Dhar Mehraz, Sidi Mohamed Ben Abdellah University, Fez, Morocco.
Abdelfattah Abdellaoui: Department of Biology, Laboratory of Physiology Pharmacology and Environmental Health, Faculty of Sciences Dhar Mehraz, Sidi Mohamed Ben Abdellah University, Fez, Morocco.
The objective of this study was to evaluate the antibacterial activity of (cinnamon) essential oil (EO) alone and in combination with some classical antibiotics against three multidrug-resistant bacteria, , , and , to search a possible synergy. The antibacterial activity of all tested compounds was determined by agar disc diffusion and minimum inhibitory concentration assays. The checkerboard method was used to quantify the efficacy of cinnamon EO in combination with these antibiotics. Fractional inhibitory concentrations were calculated and interpreted as synergy, addition, indifferent, or antagonism. A synergistic interaction was shown against with the combination cinnamon EO and ampicillin or chloramphenicol and against when cinnamon EO was combined with chloramphenicol. However, the combination of cinnamon oil and streptomycin displayed additive effects against all bacteria stains. The combinations of cinnamon EO and antibiotics can be used as an alternative therapeutic application, which can decrease the minimum effective dose of the drugs, thus reducing their possible adverse effects and the costs of treatment.
