OpenLB
Open Library of Bioscience
Advanced Search
Journal of experimental & clinical cancer research : CR
May 16, 2019;38 (1): 198.

Molecular pattern of lncRNAs in hepatocellular carcinoma.

Haoming Mai, Bin Zhou, Li Liu, Fu Yang, Carly Conran, Yuan Ji, Jinlin Hou, Deke Jiang
Author Information
  1. Haoming Mai: State Key Laboratory of Organ Failure Research, Guangdong Key Laboratory of Viral Hepatitis Research, Institute of Liver Diseases Research of Guangdong Province, Guangzhou, China.
  2. Bin Zhou: State Key Laboratory of Organ Failure Research, Guangdong Key Laboratory of Viral Hepatitis Research, Institute of Liver Diseases Research of Guangdong Province, Guangzhou, China.
  3. Li Liu: State Key Laboratory of Organ Failure Research, Guangdong Key Laboratory of Viral Hepatitis Research, Institute of Liver Diseases Research of Guangdong Province, Guangzhou, China.
  4. Fu Yang: Department of Medical Genetics, Second Military Medical University, Shanghai, 200433, China.
  5. Carly Conran: University of Illinois College of Medicine, Chicago, IL, 60612, USA.
  6. Yuan Ji: Department of Public Health Sciences, University of Chicago, Chicago, IL, 60637, USA.
  7. Jinlin Hou: State Key Laboratory of Organ Failure Research, Guangdong Key Laboratory of Viral Hepatitis Research, Institute of Liver Diseases Research of Guangdong Province, Guangzhou, China.
  8. Deke Jiang: State Key Laboratory of Organ Failure Research, Guangdong Key Laboratory of Viral Hepatitis Research, Institute of Liver Diseases Research of Guangdong Province, Guangzhou, China. dekejiang17@smu.edu.cn.
PMID: 31097003 DOI: 10.1186/s13046-019-1213-0

Abstract

Hepatocellular carcinoma (HCC) is one of the most notable lethal malignancies worldwide. However, the molecular mechanisms involved in the initiation and progression of this disease remain poorly understood. Over the past decade, many studies have demonstrated the important regulatory roles of long non-coding RNAs (lncRNAs) in HCC. Here, we comprehensively review recent discoveries regarding HCC-associated lncRNA functions, which we have classified and described according to their mechanism models.

Keywords

Hepatocellular carcinoma Molecular pattern Regulation of biological processes Well-characterized mechanism lncRNA

References

  1. Oncogene. 1999 Mar 11;18(10):1855-66 [PMID: 10086340]
  2. Nat Genet. 2000 Jun;25(2):239-40 [PMID: 10835646]
  3. Nature. 2001 Feb 15;409(6822):860-921 [PMID: 11237011]
  4. Nature. 2004 Oct 21;431(7011):931-45 [PMID: 15496913]
  5. Exp Mol Med. 2006 Feb 28;38(1):1-10 [PMID: 16520547]
  6. Ann Intern Med. 2006 Nov 7;145(9):676-84 [PMID: 17088581]
  7. Nat Struct Mol Biol. 2007 Feb;14(2):103-5 [PMID: 17277804]
  8. Cell. 2008 Jan 11;132(1):9-14 [PMID: 18191211]
  9. Mol Cell. 2008 Feb 29;29(4):499-509 [PMID: 18313387]
  10. Nature. 2009 Mar 12;458(7235):223-7 [PMID: 19182780]
  11. Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11667-72 [PMID: 19571010]
  12. Nature. 2010 Apr 15;464(7291):1071-6 [PMID: 20393566]
  13. Ann Surg Oncol. 2011 May;18(5):1243-50 [PMID: 21327457]
  14. Cell. 2011 Aug 5;146(3):353-8 [PMID: 21802130]
  15. Hepatology. 2012 Aug;56(2):622-31 [PMID: 22370893]
  16. Proc Natl Acad Sci U S A. 2012 May 29;109(22):8646-51 [PMID: 22586128]
  17. Annu Rev Biochem. 2012;81:145-66 [PMID: 22663078]
  18. Hepatology. 2012 Dec;56(6):2231-41 [PMID: 22706893]
  19. Nature. 2012 Sep 6;489(7414):57-74 [PMID: 22955616]
  20. Nature. 2012 Sep 6;489(7414):101-8 [PMID: 22955620]
  21. Science. 2012 Sep 7;337(6099):1159, 1161 [PMID: 22955811]
  22. Genome Res. 2012 Sep;22(9):1775-89 [PMID: 22955988]
  23. Cancer Res. 2012 Dec 1;72(23):6163-72 [PMID: 23026137]
  24. Carcinogenesis. 2013 Mar;34(3):577-86 [PMID: 23222811]
  25. Hepatology. 2013 May;57(5):1882-92 [PMID: 23239537]
  26. Mol Cell. 2013 Mar 28;49(6):1083-96 [PMID: 23395002]
  27. Int J Biochem Cell Biol. 2013 Aug;45(8):1895-910 [PMID: 23748105]
  28. Nat Struct Mol Biol. 2013 Nov;20(11):1250-7 [PMID: 24077223]
  29. Nat Rev Mol Cell Biol. 2013 Nov;14(11):699-712 [PMID: 24105322]
  30. Nat Struct Mol Biol. 2014 Feb;21(2):198-206 [PMID: 24463464]
  31. Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4173-8 [PMID: 24594601]
  32. Cell Res. 2014 May;24(5):513-31 [PMID: 24662484]
  33. Cancer Cell. 2014 May 12;25(5):666-81 [PMID: 24768205]
  34. Oncogene. 2015 Apr 23;34(17):2178-2188 [PMID: 24954509]
  35. Nat Rev Genet. 2014 Sep;15(9):599-612 [PMID: 25022902]
  36. Mol Cell. 2014 Jul 17;55(2):157-8 [PMID: 25038410]
  37. Hepatology. 2014 Oct;60(4):1278-90 [PMID: 25043274]
  38. Cancer Cell. 2014 Sep 8;26(3):309-317 [PMID: 25203320]
  39. Gastroenterology. 2015 Feb;148(2):415-26.e18 [PMID: 25449213]
  40. Nat Genet. 2015 Mar;47(3):199-208 [PMID: 25599403]
  41. Neoplasia. 2015 Jan;17(1):79-88 [PMID: 25622901]
  42. Cell Stem Cell. 2015 Apr 2;16(4):413-25 [PMID: 25842979]
  43. Hepatology. 2016 Feb;63(2):499-511 [PMID: 25964079]
  44. J Hematol Oncol. 2015 May 14;8:50 [PMID: 25966845]
  45. J Hepatol. 2015 Oct;63(4):886-95 [PMID: 26024833]
  46. Gastroenterology. 2015 Oct;149(5):1226-1239.e4 [PMID: 26099527]
  47. Carcinogenesis. 2015 Oct;36(10):1136-43 [PMID: 26163879]
  48. Biochim Biophys Acta. 2016 Feb;1863(2):335-46 [PMID: 26658161]
  49. Hepatology. 2016 Mar;63(3):850-63 [PMID: 26663434]
  50. Nat Rev Genet. 2016 Jan;17(1):47-62 [PMID: 26666209]
  51. Clin Cancer Res. 2016 Apr 15;22(8):2041-50 [PMID: 26667486]
  52. J Hepatol. 2016 Jun;64(6):1283-94 [PMID: 26812074]
  53. Cancer Cell. 2016 Apr 11;29(4):452-463 [PMID: 27070700]
  54. Nat Genet. 2016 Jul;48(7):747-57 [PMID: 27213290]
  55. Nat Struct Mol Biol. 2016 Jul;23(7):631-9 [PMID: 27239797]
  56. Hepatology. 2016 Oct;64(4):1033-48 [PMID: 27338022]
  57. J Mol Med (Berl). 2016 Nov;94(11):1281-1296 [PMID: 27380494]
  58. Oncogene. 2017 Feb 16;36(7):942-955 [PMID: 27452518]
  59. Nat Genet. 2016 Oct;48(10):1142-50 [PMID: 27526323]
  60. Nat Commun. 2016 Aug 24;7:12598 [PMID: 27553854]
  61. FEBS J. 2016 Oct;283(20):3739-3754 [PMID: 27573079]
  62. Int J Mol Sci. 2016 Sep 23;17(10): [PMID: 27669232]
  63. Biomed Pharmacother. 2017 Jan;85:348-354 [PMID: 27899259]
  64. Nat Commun. 2016 Dec 01;7:13608 [PMID: 27905400]
  65. Hepatology. 2017 May;65(5):1612-1627 [PMID: 28027578]
  66. Biomed Pharmacother. 2017 May;89:926-932 [PMID: 28292020]
  67. Cell Death Dis. 2017 Mar 16;8(3):e2675 [PMID: 28300839]
  68. J Hematol Oncol. 2017 Apr 19;10(1):91 [PMID: 28420424]
  69. J Hepatol. 2017 Sep;67(3):603-618 [PMID: 28438689]
  70. J Cell Biochem. 2017 Dec;118(12):4498-4507 [PMID: 28464252]
  71. J Pathol. 2017 Aug;242(4):421-434 [PMID: 28493484]
  72. Nat Commun. 2017 May 25;8:15129 [PMID: 28541302]
  73. Nat Cell Biol. 2017 Jul;19(7):820-832 [PMID: 28553938]
  74. J Hematol Oncol. 2017 Jun 8;10(1):115 [PMID: 28595628]
  75. Hepatology. 2018 Jan;67(1):171-187 [PMID: 28746790]
  76. Cancer Res. 2017 Dec 1;77(23):6704-6716 [PMID: 28947421]
  77. Cell Physiol Biochem. 2017;43(5):1926-1938 [PMID: 29055955]
  78. J Cell Physiol. 2018 Jun;233(6):4726-4734 [PMID: 29139562]
  79. Oncogene. 2018 Mar;37(11):1445-1456 [PMID: 29311643]
  80. Cell. 2018 Jan 25;172(3):393-407 [PMID: 29373828]
  81. Mol Cancer. 2018 Feb 21;17(1):63 [PMID: 29466992]
  82. Curr Opin Cell Biol. 2018 Jun;52:96-104 [PMID: 29518673]
  83. Mol Cancer. 2018 Mar 14;17(1):73 [PMID: 29540185]
  84. Biochem Biophys Res Commun. 2018 May 15;499(3):702-710 [PMID: 29605299]
  85. Cell Physiol Biochem. 2018;46(3):1122-1133 [PMID: 29669339]
  86. Nat Commun. 2018 Apr 20;9(1):1572 [PMID: 29679004]
  87. Cell Death Dis. 2018 Apr 30;9(5):478 [PMID: 29706626]
  88. Am J Cancer Res. 2018 Apr 01;8(4):688-698 [PMID: 29736313]
  89. Biomed Pharmacother. 2018 Aug;104:137-144 [PMID: 29772433]
  90. Hepatology. 2018 Dec;68(6):2130-2144 [PMID: 29790592]
  91. Cell. 2018 Jul 26;174(3):576-589.e18 [PMID: 30033361]
  92. Cell. 2018 Jul 26;174(3):564-575.e18 [PMID: 30033362]
  93. Theranostics. 2018 Jun 13;8(14):3751-3765 [PMID: 30083257]
  94. Carcinogenesis. 2018 Dec 31;39(12):1438-1446 [PMID: 30169594]
  95. CA Cancer J Clin. 2018 Nov;68(6):394-424 [PMID: 30207593]
  96. Nature. 1970 Aug 8;227(5258):561-3 [PMID: 4913914]

Grants

  1. 81472618/the General Programs from the National Natural Science Foundation of China
  2. 81670535/the General Programs from the National Natural Science Foundation of China
  3. 2017ZX10202202/the National Science and Technology Major Project
  4. 2018ZX10301202/the National Science and Technology Major Project
  5. 2017BT01S131/the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program
  6. 2017GXNSFGA198002/the Innovative Research Team Project of Guangxi Province
  7. 2017J001/the Grant for Recruited Talents to Start Scientific Research from Nanfang Hospital, and the Distinguished Youth Scholars Incubation Project of Nanfang Hospital
Journal Article Review
Article has an altmetric score of 1

Word Cloud

Created with Highcharts 10.0.0carcinomaHepatocellularHCClncRNAslncRNAmechanismMolecularpatternonenotablelethalmalignanciesworldwideHowevermolecularmechanismsinvolvedinitiationprogressiondiseaseremainpoorlyunderstoodpastdecademanystudiesdemonstratedimportantregulatoryroleslongnon-codingRNAscomprehensivelyreviewrecentdiscoveriesregardingHCC-associatedfunctionsclassifieddescribedaccordingmodelshepatocellularRegulationbiologicalprocessesWell-characterized

Similar Articles

Cited By