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The Indian journal of medical research
02, 2019;149 (2): 129-145.

Efflux pump inhibitors for bacterial pathogens: From bench to bedside.

Atin Sharma, Vivek Kumar Gupta, Ranjana Pathania
Author Information
  1. Atin Sharma: Department of Biotechnology, Indian Institute of Technology, Roorkee, India.
  2. Vivek Kumar Gupta: Department of Biotechnology, Indian Institute of Technology, Roorkee, India.
  3. Ranjana Pathania: Department of Biotechnology, Indian Institute of Technology, Roorkee, India.
PMID: 31219077 DOI: 10.4103/ijmr.IJMR_2079_17

Abstract

With the advent of antibiotics, bacterial infections were supposed to be a thing of past. However, this instead led to the selection and evolution of bacteria with mechanisms to counter the action of antibiotics. Antibiotic efflux is one of the major mechanisms, whereby bacteria pump out the antibiotics from their cellular interior to the external environment using special transporter proteins called efflux pumps. Inhibiting these pumps seems to be an attractive strategy at a time when novel antibiotic supplies are dwindling. Molecules capable of inhibiting these pumps, known as efflux pump inhibitors (EPIs), have been viewed as potential therapeutic agents that can rejuvenate the activity of antibiotics that are no longer effective against bacterial pathogens. EPIs follow some general mechanisms of efflux inhibition and are derived from various natural as well as synthetic sources. This review focuses on EPIs and identifies the challenges that have kept these futuristic therapeutics away from the commercial realm so far.

Keywords

Antibiotics efflux pumps multiple drug resistance pathogens therapeutics

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MeSH Term

Anti-Bacterial Agents
Anti-Infective Agents
Bacteria
Bacterial Infections
Drug Resistance, Multiple, Bacterial
Humans
India
Membrane Transport Proteins

Chemicals

Anti-Bacterial Agents
Anti-Infective Agents
Membrane Transport Proteins
Journal Article Review
Article has an altmetric score of 7

Word Cloud

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