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Genetics and molecular biology
2019 Apr-Jun;42 (2): 411-424.

Ecophysiology, genotoxicity, histopathology, and gene responses of naphthalene injected Colossoma macropomum (Cuvier, 1818) exposed to hypoxia.

Samara Silva de Souza, Grazyelle Sebrenski da Silva, Vera Maria Fonseca de Almeida-Val
Author Information
  1. Samara Silva de Souza: Laboratory of Ecophysiology and Molecular Evolution, National Institute for Research in the Amazon (INPA), Manaus, AM, Brazil. ORCID
  2. Grazyelle Sebrenski da Silva: Laboratory of Ecophysiology and Molecular Evolution, National Institute for Research in the Amazon (INPA), Manaus, AM, Brazil. ORCID
  3. Vera Maria Fonseca de Almeida-Val: Laboratory of Ecophysiology and Molecular Evolution, National Institute for Research in the Amazon (INPA), Manaus, AM, Brazil. ORCID
PMID: 31259356 DOI: 10.1590/1678-4685-GMB-2018-0084

Abstract

The present study aimed to evaluate the biological responses of Colossoma macropomum to naphthalene injection and subsequent hypoxia exposure, emphasizing the expression of the tumor suppressor gene tp53. Tambaquis were intraperitoneally injected with naphthalene (50 mg/kg) and, after 96 hours, the fish were transferred to respirometry chambers and, submitted to progressive hypoxia for the determination of critical PO2. In a subsequent experiment, the fish received an intraperitoneal injection of naphthalene and were kept for 96 hours under normoxia. Successively, fish were challenged with acute hypoxia (PO2

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